Latest Research
All publications from the Cancer3.AI database, newest first.
[A psychotic decompensation after meningioma surgery].
van Velthoven FG, et al
Researchers from the Netherlands report a case study of a 55-year-old woman whose long-standing psychiatric and cognitive symptoms were ultimately traced to a benign frontal meningioma — a slow-growing brain tumor. After the tumor was surgically removed, the patient unexpectedly developed severe psychotic decompensation, highlighting that brain surgery itself can trigger significant psychiatric crises. The case underscores that the relationship between brain tumors, their removal, and mental health outcomes is complex and not fully predictable. Clinicians are urged to adopt an interdisciplinary approach — involving psychiatrists, neurosurgeons, and neuropsychologists — ideally before surgery takes place, in order to identify patients who may be at elevated risk for post-operative psychiatric deterioration. This report serves as an important reminder that successful tumor resection does not automatically translate into improved mental health, and that psychiatric follow-up planning should be an integral part of neurosurgical care.
Tijdschrift voor psychiatrie
Source →Postoperative rehabilitation of a patient with resected aggressive parasagittal meningioma infiltrating the superior sagittal sinus and presenting with paraplegia.
Hombolevska V, et al
Researchers from Poland report a detailed case study of a 47-year-old woman who underwent surgery for an aggressive parasagittal meningioma, a type of brain tumor that had infiltrated a major venous structure called the superior sagittal sinus. Following microsurgical removal of the tumor, the patient developed bilateral spastic paralysis of both legs, further complicated by cerebrospinal fluid leakage and a surgical site infection. The medical team implemented an intensive, multidisciplinary rehabilitation program encompassing physiotherapy, verticalization training, gait retraining, proprioceptive neuromuscular facilitation, and psychological support. Despite the severity of her neurological deficits, early and structured rehabilitation contributed to meaningful functional improvement and helped preserve quality of life. This case underscores the critical importance of initiating comprehensive rehabilitation as soon as possible after complex neurosurgical procedures, particularly when severe motor complications arise. Clinicians treating patients with parasagittal meningiomas involving the superior sagittal sinus should anticipate significant postoperative neurological risks and plan for coordinated rehabilitation from the outset.
Wiadomosci lekarskie (Warsaw, Poland : 1960)
Source →Imiquimod Treatment for Conjunctival Melanoma In Situ or Ocular Surface Squamous Neoplasia.
Bowen RC, et al
Researchers at a tertiary referral center evaluated whether compounded imiquimod 5% ointment — an immune-stimulating drug typically used for skin conditions — could safely and effectively treat two rare but serious eye surface cancers: conjunctival melanoma in situ and ocular surface squamous neoplasia. Five patients (mean age 77 years) applied the ointment to the conjunctival surface five days per week for 12 to 15 weeks, with outcomes confirmed by both clinical examination and tissue biopsy. By 12 weeks, patients showed complete or partial histological responses, including full resolution of conjunctival intraepithelial neoplasia and melanoma in situ, with one case of primary acquired melanosis achieving complete response by 15 weeks. All patients experienced mild, temporary side effects limited to the eye surface and eyelids, which resolved within one to two weeks of pausing or completing treatment. These findings suggest that imiquimod ointment may offer a safer alternative to current standard treatments such as mitomycin C and 5-fluorouracil, though the authors caution that larger studies with longer follow-up are needed to confirm efficacy and safety.
JAMA ophthalmology
Source →Advancing Gastric Cancer Prevention in Korea: Current Strategies and Future Directions.
Park JY, et al
A new review published in Helicobacter examines South Korea's progress in combating gastric cancer, one of the country's most significant public health challenges. South Korea has achieved remarkable gains, with gastric cancer falling from the most common cancer in 2018 to fifth place by 2022, and five-year survival rates now exceeding 75%, driven by the national screening program launched in 1999 that offers biennial endoscopic exams to adults aged 40 and older. A key focus of the review is the ongoing HELPER trial, conducted in collaboration with the International Agency for Research on Cancer, which has enrolled over 12,000 average-risk Koreans to test whether eradicating Helicobacter pylori bacteria—a major cause of gastric cancer—can reduce cancer incidence in the general population, with participants randomized to bismuth quadruple therapy or placebo. The national screening program has demonstrated clear benefits including higher detection of early-stage disease, reduced mortality, and greater use of minimally invasive endoscopic treatments. However, the authors highlight that the current one-size-fits-all screening approach lacks individual risk stratification and is costly, and they advocate for future strategies that integrate H. pylori eradication with objective assessment of gastric atrophy to create more personalized, cost-effective prevention pathways.
Helicobacter
Source →[The results of surgical interventions for colon cancer with spread to the organs of the pancreatoduodenal zone].
Gevorkyan YA, et al
Researchers at the National Medical Research Center of Oncology in Russia conducted a retrospective study examining surgical outcomes in 38 patients with colon cancer that had spread to involve the pancreatoduodenal zone — a complex anatomical region encompassing the pancreas and duodenum — between 2013 and 2024. All patients underwent extensive combined operations, including various forms of hemicolectomy paired with pancreatic or duodenal resections, with surgeries averaging nearly five hours and blood loss averaging 300 milliliters. Postoperative complications occurred in nearly 40% of patients, most commonly postoperative pancreatitis, pancreatic necrosis, and intra-abdominal bleeding, with a postoperative mortality rate of 5.3%. Long-term survival data showed that 60.5% of patients had died by the time of reporting, though median survival in the duodenal resection subgroup reached approximately 22.5 months. The authors conclude that while these operations carry higher risk than standard colon cancer surgery, they remain a viable option when combined with chemotherapy and can achieve meaningful long-term survival for carefully selected patients. This study highlights the importance of specialized oncological centers in managing locally advanced colorectal cancer involving adjacent organ systems.
Khirurgiia
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