Latest Research
All publications from the Cancer3.AI database, newest first.
CD5-positive diffuse large B-Cell lymphoma presenting with protein-losing enteropathy.
Moriwaki K, et al
Researchers report the case of a 60-year-old woman who suffered four years of refractory diarrhea and progressive leg swelling before being diagnosed with CD5-positive diffuse large B-cell lymphoma (DLBCL) of the small intestine, a rare aggressive blood cancer. The unusual presentation involved protein-losing enteropathy, a condition in which proteins leak from the gastrointestinal tract into the bowel, causing dangerously low blood protein levels and fluid accumulation in the limbs. Advanced diagnostic techniques, including double-balloon endoscopy and tissue biopsy, confirmed the diagnosis by revealing characteristic ulcers and the CD5-positive DLBCL cell type. Treatment with an intensive chemotherapy regimen called DA-EPOCH-R, followed by high-dose chemotherapy and autologous stem cell transplantation, successfully restored normal protein levels and achieved sustained remission. The authors highlight that this case closely resembles a previously published report of the same rare combination, suggesting that CD5-positive DLBCL presenting with protein-losing enteropathy may constitute a distinct and recognizable clinical entity that clinicians should consider when evaluating patients with prolonged, unexplained gastrointestinal protein loss.
Journal of clinical and experimental hematopathology : JCEH
Source →A Narrative Review on Unravelling Bacterial-Mediated Carcinogenesis and Possible Alternative Treatment Strategies.
Sohel M, et al
This narrative review examines the role of bacteria in driving cancer development, a topic less explored than chemical, physical, or viral carcinogenesis. Researchers compiled mechanistic evidence showing that bacteria such as Helicobacter pylori, Fusobacterium spp., Salmonella typhi, Staphylococcus aureus, Chlamydia pneumoniae, and Mycobacterium tuberculosis can trigger cancer through multiple pathways, including activation of oncogenic signaling cascades (NF-κB, MAPK, PI3K-Akt, JAK/STAT), suppression of tumor suppressor proteins like p53 and pRb, promotion of chronic inflammation via cytokines such as TNF-α and various interleukins, and generation of free radicals that damage DNA. These bacterial mechanisms have been linked to cancers of the breast, colon, pancreas, stomach, lung, gallbladder, and oral cavity. The review also highlights promising alternative treatment strategies, including natural phytochemicals and nanotechnology-based drug delivery systems, which may counteract bacterial carcinogenesis by modulating cell cycle proteins, inducing apoptosis, and acting as antioxidants. For clinicians and patients, this work underscores the importance of recognizing bacterial infections as modifiable cancer risk factors and points toward novel preventive and therapeutic avenues beyond conventional antibiotics.
BioMed research international
Source →Emergent Endovascular Parent Artery Occlusion for Type III Carotid Blowout Syndrome After Charged Particle Therapy for Recurrent Maxillary Carcinoma: A Case Report and Literature Review.
Wajima D, et al
This case report describes the emergency endovascular treatment of a 55-year-old woman who developed type III carotid blowout syndrome (CBS), a life-threatening rupture of the carotid artery, following charged particle radiation therapy administered nine years earlier for recurrent maxillary carcinoma. The patient arrived in shock with active bleeding from the oral and nasal cavity, and digital subtraction angiography confirmed active hemorrhage from the cavernous portion of the left internal carotid artery. Emergent parent artery occlusion (PAO) using coil embolization successfully stopped the bleeding, but the following day the patient required additional surgical bypass procedures — anastomoses of the superficial temporal and middle cerebral arteries — to prevent stroke caused by reduced blood flow. The authors highlight that PAO is the preferred endovascular approach for type III CBS, while covered stents represent an alternative for patients who cannot tolerate PAO. This case underscores the critical importance of multidisciplinary vigilance in recognizing early warning signs of CBS in head and neck cancer patients who have received radiation therapy, as uncontrolled carotid hemorrhage carries extremely high mortality rates, especially outside hospital settings.
Turkish neurosurgery
Source →[Approaches in microsurgery for olfactory meningiomas: a systematic review and meta-analysis].
Abdullaev AN, et al
A new systematic review and meta-analysis published in the Russian journal Zhurnal voprosy neirokhirurgii examined the safety and effectiveness of different surgical approaches used to remove olfactory meningiomas, brain tumors originating near the olfactory groove that account for up to 18% of all intracranial meningiomas. Researchers analyzed data from 15 studies encompassing 634 patients, finding that the bilateral subfrontal approach was the most commonly used technique (36% of cases), while the endoscopic transnasal approach was employed in 22% of cases. The most frequent preoperative symptom was loss or reduction of smell (62% of patients), and gross total tumor removal (Simpson grade I/II) was achieved in 81% of all cases across the different surgical methods. The study concluded that no single surgical approach is universally superior, and that the optimal technique must be chosen based on individual patient factors including tumor size and growth direction, severity of brain swelling, and the specific anatomy of the patient's paranasal sinuses. These findings provide clinicians with a comprehensive evidence base to guide personalized surgical planning for patients diagnosed with olfactory meningiomas.
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
Source →Computed Tomographic Features of Benign and Malignant External Ear Canal Neoplasms in 39 Dogs.
Veitch K, et al
A multicenter study published in Veterinary Radiology & Ultrasound examined computed tomography (CT) findings in 39 dogs with 41 external ear canal tumors to determine whether imaging alone could distinguish benign from malignant growths. Researchers compared a range of CT characteristics, including tissue shape, density, contrast enhancement patterns, bone involvement, and effects on surrounding structures, with consensus readings by two veterinary radiologists. The most frequently diagnosed tumor types were ceruminous gland adenocarcinoma, a malignant cancer of the ear's wax-producing glands, and ceruminous gland adenoma, its benign counterpart. While malignant tumors more often showed irregular density, uneven contrast enhancement, aggressive bone reactions, and invasion of nearby structures, some benign tumors also displayed worrying features such as bone destruction, creating significant overlap between the two categories. The findings confirm that CT imaging can help veterinarians prioritize their list of suspected diagnoses but cannot definitively differentiate benign from malignant ear canal masses, making tissue biopsy essential for a conclusive diagnosis. This study provides important guidance for veterinary clinicians planning surgery or treatment for dogs with ear canal tumors.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Source →