Latest Research
All publications from the Cancer3.AI database, newest first.
Leiomyosarcoma of the orbit: A case report and review of literature.
Ramdulari AV, et al
Researchers present a rare case of orbital leiomyosarcoma, a soft-tissue cancer affecting the eye socket, along with a comprehensive review of fewer than 40 previously reported cases in the medical literature. The patient, who developed progressive protrusion of the left eye, was successfully treated with surgical removal of the tumor followed by postoperative radiotherapy and was found to be disease-free at the last follow-up. The literature review revealed that 84% of orbital leiomyosarcoma patients underwent surgery and 42% received radiotherapy as part of their treatment. A notable finding was that 15% of patients had a childhood history of retinoblastoma, a cancer of the eye, and all of these patients had received radiotherapy for bilateral retinoblastoma during childhood, suggesting a possible link between prior radiation exposure and later development of this rare sarcoma. These findings are clinically important because they highlight orbital leiomyosarcoma as an extremely rare but treatable malignancy and underscore the need for long-term monitoring of childhood cancer survivors who received radiotherapy.
Journal of cancer research and therapeutics
Source →Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial.
Li S, et al
A sub-study of the large COSMOS randomized clinical trial examined whether two years of daily multivitamin-multimineral (MVM) supplementation (Centrum Silver®) altered blood metabolite profiles in 399 older US adults averaging 70 years of age. Using an advanced nuclear magnetic resonance platform, researchers tracked 168 metabolites, seven biological aging clocks derived from metabolomics, and 24 metabolomic risk scores for chronic diseases at baseline, one year, and two years. Compared to placebo, MVM supplementation modestly raised levels of beneficial omega-3 fatty acids including docosahexaenoic acid (DHA), slowed the rise of creatinine (a marker of kidney stress), and lowered metabolomic risk scores for 16 chronic conditions including cardiovascular disease, dementia, renal disease, glaucoma, liver disease, and prostate cancer. MVM also produced a non-significant reduction of roughly half a year to just over one year across all metabolomic aging clocks, suggesting a potential slowing of biological aging. However, all observed effects reached only nominal statistical significance and did not survive correction for multiple comparisons, likely due to the modest sample size. These preliminary findings support the possibility that daily multivitamins may beneficially shift the body's metabolic landscape in older adults, but larger confirmatory studies within COSMOS are needed before firm clinical recommendations can be made.
GeroScience
Source →Kaposi sarcoma with extensive thoracic involvement.
Gomes AC, et al
This case report published in a Brazilian tropical medicine journal describes a patient with Kaposi sarcoma presenting with extensive involvement of the thoracic cavity, a rare and particularly severe manifestation of the disease. Kaposi sarcoma is a vascular tumor associated with human herpesvirus 8 (HHV-8) infection and is most commonly diagnosed in immunocompromised individuals, particularly those living with HIV/AIDS. Thoracic Kaposi sarcoma can affect the lungs, pleura, and mediastinum, often leading to respiratory complications that may be mistaken for other pulmonary conditions. This case highlights the diagnostic challenges clinicians face when encountering atypical or aggressive presentations of Kaposi sarcoma in the chest, underscoring the importance of maintaining a high index of suspicion in at-risk populations. Timely recognition and appropriate management of thoracic involvement are critical to improving patient outcomes in this life-threatening presentation.
Revista da Sociedade Brasileira de Medicina Tropical
Source →Freestyle Multiperforator Island Flap for Reconstruction of Extensive Thoracoabdominal Defects: A Case Report.
Álvarez Vásquez FA, et al
Surgeons report a case in which a novel reconstructive technique successfully repaired a large chest and abdominal wall defect in a patient with recurrent breast cancer. After removing the tumor and part of the chest wall, the team used a Freestyle Multiperforator Island Flap — a locally harvested flap of skin and tissue based on blood vessels identified in real time during surgery — to cover the wound, including exposed synthetic mesh and bone fixation hardware. The flap was intentionally designed with a smaller attachment area to allow greater movement and flexibility, and it achieved complete survival with no complications. At one year of follow-up, the patient maintained durable wound coverage, good chest shape, and preserved function. This approach is particularly valuable when conventional or free-flap reconstructions are not feasible due to patient anatomy or resource constraints, expanding the toolkit available to reconstructive surgeons managing complex oncologic defects.
Annals of plastic surgery
Source →Cellector: A tool to detect foreign genotype cells in scRNAseq data with applications in leukemia and microchimerism.
Heaton H, et al
Researchers developed Cellector, a computational tool designed to identify rare cells with foreign genetic profiles within single-cell RNA sequencing (scRNAseq) datasets. The tool addresses a critical clinical need in leukemia patients who have undergone hematopoietic cell transplantation (HCT), where the presence of residual patient-origin cells among donor-derived blood cells can signal measurable residual disease (MRD) and potential cancer relapse. Cellector was shown to accurately detect microchimeric cells — genetically distinct cells present in very small numbers — at frequencies as low as 0.05% or below, demonstrating exceptional sensitivity. Beyond leukemia monitoring, the tool has broader applications including the study of naturally occurring microchimerism, such as the exchange of cells between mother and fetus during pregnancy. By enabling more precise MRD quantification, Cellector has the potential to improve clinical decision-making for transplant patients and may ultimately help clinicians intervene earlier when leukemia relapse is suspected.
bioRxiv : the preprint server for biology
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