Orbit & Lacrimal Gland
Prognosis
This section is being prepared by our editorial process.
🔬 Histological Types
📚 Latest Research
Orbital Extranodal Marginal-Zone Lymphoma and Crystal-Storing Histiocytosis Related to a Longstanding Silicone Scleral Buckle.
Langley L, et al
A rare case of orbital extranodal marginal-zone lymphoma (EMZL) co-occurring with crystal-storing histiocytosis was found to be causally linked to the chronic presence of a silicone scleral buckle implant, suggesting that long-term foreign-body antigenic stimulation may drive mucosa-associated lymphoid tissue (MALT)-type lymphomagenesis in the orbit. This report highlights a previously underrecognized etiological pathway for a malignancy that, while indolent, requires prompt diagnosis and oncological management. Clinicians managing patients with longstanding ophthalmic implants should be aware of the potential for neoplastic transformation, and the case underscores the importance of histopathological evaluation of orbital masses in this clinical context.
Ophthalmic plastic and reconstructive surgery
Source →Orbital spindle cell neoplasm with neural differentiation: diagnostic challenges in the absence of molecular confirmation.
Asensio-Sánchez VM, et al
A case report describes an 82-year-old man with a history of treated rectal adenocarcinoma who presented with progressive orbital pain and right-sided proptosis, in whom orbital exenteration and histopathological examination revealed a high-grade infiltrative spindle cell neoplasm at the orbital apex consistent with a malignant peripheral nerve sheath tumor (MPNST). Immunohistochemical profiling demonstrated diffuse positivity for S100 and SOX10, negativity for melanocytic, muscular, epithelial, and vascular markers, and an elevated Ki-67 proliferative index of approximately 50%, supporting neural differentiation while H3K27me3 staining — a key molecular marker — was unavailable. This case underscores the diagnostic limitations of MPNST in the absence of molecular confirmation and argues that the diagnosis must be treated as an integrative hypothesis requiring rigorous clinicoradiologic-pathologic correlation. From a surgical perspective, the case supports the role of radical procedures such as orbital exenteration in infiltrative, high-grade malignancies of the orbital apex with neurovascular compromise.
Archivos de la Sociedad Espanola de Oftalmologia
Source →DOTATATE-PET in custom spheno-orbital implant design for meningiomas with orbital involvement: a case series.
Tennyson JM, et al
A study of 4 patients with hyperostosing spheno-orbital meningiomas demonstrated that integrating DOTATATE-PET molecular imaging into the design of custom polyetheretherketone (PEEK) patient-specific implants enabled single-implant reconstruction of combined skull and orbital defects, with visual outcomes stabilizing or improving in all 4 patients and the exophthalmos index returning to normal in 3 of the 4. Critically, DOTATATE-PET revealed transosseous tumor infiltration extending beyond the structural hyperostosis visible on standard CT and MRI, directly informing both the extent of planned bony resection and the implant design in 3 patients who had PET/CT data available. The only complications observed were transient diplopia and a pseudomeningocele in 1 patient, both resolving with conservative management, while no enophthalmos or implant-related complications occurred in any patient.
Neurosurgical focus
Source →💊 Therapies
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🧪 Tumor markers
This section is being prepared by our editorial process.