Soft Tissue

C47, C49WHO Vol. 3

Bone, Cartilage & Soft Tissue

Prognosis

This section is being prepared by our editorial process.

🔬 Histological Types

📚 Latest Research

2026-09-10

Management of Soft Tissue and Visceral Leiomyosarcomas.

Campos F, et al

An international expert panel has published a consensus-based review in JAMA Oncology on the diagnosis and management of leiomyosarcoma, a rare and heterogeneous malignant soft tissue neoplasm associated with substantial morbidity and mortality. In localized disease, complete surgical resection remains the cornerstone of treatment with site-specific perioperative strategies, while prospective data supporting neoadjuvant or adjuvant chemotherapy remain lacking and the role of radiotherapy varies across anatomic sites. In advanced disease, active systemic regimens include anthracycline-based and gemcitabine-based combinations, trabectedin, and tyrosine kinase inhibitors, though optimal sequencing beyond first-line therapy is undefined and emerging data suggest benefit from treatment continuation strategies and local therapies in oligometastatic settings. The panel identified integration of molecular profiling into routine diagnostic pathways as a key unmet need, and concluded that management requires a multidisciplinary, site-specific approach informed by limited but evolving evidence.

JAMA oncology

Source →

2026-09-10

Metastatic alveolar rhabdomyosarcoma to the orbit: a case report and literature review.

Yu AJ, et al

This case report describes an uncommon presentation of metastatic alveolar rhabdomyosarcoma involving the orbit, a rare but clinically significant manifestation of this aggressive soft tissue sarcoma. The authors document the diagnostic workup, clinical features, and management of the affected patient, supplemented by a systematic review of previously reported cases in the literature. Orbital metastasis from rhabdomyosarcoma poses considerable diagnostic challenges given its rarity and the potential to mimic primary orbital tumours, making prompt recognition critical for timely oncological treatment. The findings underscore the importance of considering rhabdomyosarcoma in the differential diagnosis of orbital masses in patients with a known or suspected soft tissue sarcoma.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Source →

2026-09-09

The liminal diagnosis: how language shapes identity and care in desmoid tumours.

Clark BJ

A new essay published in Medical Humanities argues that desmoid tumours represent a paradigmatic „liminal diagnosis," in which patients are variously told their tumour is „benign," „borderline," or „cancer," and that this inconsistent clinical language compounds psychological and social distress beyond mere semantic confusion. Drawing on patient experience, psycho-oncology literature, and medical anthropology, the authors show that diagnostic terminology actively shapes treatment decisions, personal relationships, and overall well-being in ways that remain largely overlooked in both research and clinical practice. The paper calls for dedicated studies into the direct impact of language on care and patient experience in this rare, locally aggressive soft tissue tumour that causes substantial morbidity through local invasion, organ involvement, and chronic pain despite its lack of metastatic potential.

Medical humanities

Source →