Nasal Cavity & Paranasal Sinuses
Primary acinic cell carcinoma of the left nasal septum.
Madden J, et al
A case report published in BMJ Case Reports documents an exceptionally rare presentation of primary acinic cell carcinoma originating in the left nasal septum, a site where this salivary gland-type malignancy is almost never encountered. Acinic cell carcinoma typically arises in the parotid gland, a…
Source →Outcomes of Curative-Intent Endoscopic Resection Combined With Adjuvant Immune Checkpoint Inhibition for Resectable Sinonasal Mucosal Melanoma.
Ebihara T, et al
A retrospective study of 11 patients with resectable sinonasal mucosal melanoma (SNMM) found that curative-intent endoscopic resection followed by adjuvant immune checkpoint inhibitor (ICI) therapy yielded 1- and 3-year overall survival rates of 100.0% and 90.0%, respectively, but recurrence was com…
Source →Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.
Lépine C, et al
In a study of 59 patients with sinonasal intestinal-type adenocarcinoma (ITAC), high CD8⁺ T-cell density emerged as an independent prognostic factor significantly associated with improved disease-free and overall survival. Researchers also found that the immune checkpoint molecule TIM-3 — expressed …
Source →Poorly Differentiated and Biologically Aggressive Oral Rhabdomyosarcoma in 34 Young Dogs.
Cortez T, et al
A study of 34 young dogs diagnosed with oral rhabdomyosarcoma reveals an exceptionally aggressive cancer with a mean survival time of just 59 days, with all 30 patients (100%) for whom follow-up data were available ultimately euthanized due to local or metastatic disease progression. The average age…
Source →A Case of Rapidly Progressive DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma in Pregnancy.
El Shatanofy M, et al
A case report in Head & Neck reveals that DEK::AFF2 fusion-associated papillary squamous cell carcinoma, a subtype previously considered low- to intermediate-grade, can undergo rapid and aggressive progression during pregnancy. A 39-year-old woman at 29 weeks' gestation presented with a 2.9-cm recur…
Source →Case Report: Sinonasal plasmablastic lymphoma in a human immunodeficiency virus-negative elderly woman diagnosed by immunohistochemistry.
Nerune SM, et al
A rare case of sinonasal plasmablastic lymphoma — a highly aggressive mature B-cell lymphoma — was diagnosed in a 75-year-old HIV-negative, immunocompetent woman presenting with a locally destructive lesion involving the left nasal cavity, maxillary sinus, and ethmoid and frontal sinuses. Definitive…
Source →Unusual dual malignancy: basaloid squamous cell carcinoma arising from inverted papilloma with contralateral temporal bone carcinoma.
Eugine R, et al
A woman in her early 50s with a prior history of sinonasal inverted papilloma excisions 3 and 5 years earlier was diagnosed with a rare synchronous dual malignancy: sinonasal basaloid squamous cell carcinoma (BSCC) and a contralateral temporal bone non-keratinising squamous cell carcinoma, both with…
Source →Ectopic ACTH-Secreting Pituitary Adenoma of the Maxillary Sinus: A Rare Cause of Cushing's Syndrome.
Wordsworth G, et al
A 41-year-old woman with Cushing's syndrome caused by an ectopic ACTH-secreting pituitary adenoma located in the maxillary sinus achieved full remission following successful surgical removal, with the patient remaining disease-free 2.5 years after the procedure. Inferior petrosal sinus sampling conf…
Source →Giant Oncocytic Sinonasal Papilloma: A Rare Case.
Corrêa AG, et al
Clinicians have successfully treated a giant oncocytic sinonasal papilloma — the rarest subtype of sinonasal papilloma — using a minimally invasive endoscopic surgical approach, with the lesion being notably larger than those previously described in the literature. The case involved histopathologica…
Source →Genomic and Transcriptomic Analysis of Sinonasal Mucosal Melanoma and Conjunctival Melanoma.
Cui J, et al
A whole-exome and RNA sequencing study of 25 sinonasal mucosal melanomas (SNMM) and 9 conjunctival melanomas (CM) found that nearly all cases in both groups harbored alterations in the RTK-RAS signaling pathway, with RAS mutations significantly associated with shorter progression-free survival speci…
Source →Long-Term Postoperative Patient-Reported Quality of Life After Endoscopic Surgery for Sinonasal Inverted Papilloma: A Longitudinal Cohort Study.
Niemiec-Urbańczyk M, et al
A single-centre longitudinal cohort study of 69 patients with sinonasal inverted papilloma treated endoscopically found that disease-specific quality of life, as measured by the SNOT-22, remained largely stable over a mean follow-up of 63.1 ± 27.8 months, with a mean postoperative score of 25.4 ± 19…
Source →Sinonasal glomangiopericytoma presenting as refractory epistaxis: imaging, embolisation and pathological correlation.
Gaylard A, et al
A case report published in BMJ Case Reports identifies sinonasal glomangiopericytoma (GPC), an extremely rare perivascular tumour accounting for less than 0.5% of sinonasal neoplasms, as the underlying cause of refractory unilateral epistaxis in an anticoagulated man in his 60s. Haemostasis was achi…
Source →Definitive Radiation Therapy for Schneiderian Inverted Papilloma of the Soft Palate and Uvula.
Sinha R, et al
A case report published in Ear, Nose, & Throat Journal demonstrates that definitive radiation therapy can achieve remission in a patient with Schneiderian inverted papilloma arising in the atypical location of the soft palate and uvula, where surgical excision was withheld due to concerns for functi…
Source →Development and Preliminary Dosimetric Evaluation of a 3D-Printed Custom Tissue Compensator for Head and Neck Cancer Radiotherapy: A Proof-of-Concept Case Series.
Jian C, et al
A proof-of-concept case series of five head and neck cancer patients demonstrated that a patient-specific 3D-printed integrated tissue compensator can maintain geometric setup accuracy with random translational setup errors of ≤1.34 mm — comparable to traditional immobilization — while offering nume…
Source →[Application of the temporalis muscle-capularis dura-membranous-temporalis superficial fascia composite flap in the repair of tissue defects after radical resection of malignant tumors in the maxillary sinus].
Sun DZ, et al
A composite flap combining the temporalis muscle, deep temporal fascia layers, and superficial temporalis fascia has been applied to reconstruct tissue defects arising from radical resection of malignant maxillary sinus tumours, according to a study published in the Chinese Journal of Otorhinolaryng…
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