Vulva & Vagina
Incidence, survival, and symptoms at recurrence among vulvar cancer patients treated with curative intent: a population-based cohort study.
Krog L, et al
A nationwide Danish population-based cohort study of 800 vulvar squamous cell carcinoma patients found that five-year overall survival plummeted from 73.3% (95% CI 69.9–76.3) after primary diagnosis to just 38.2% (95% CI 31.5–44.9) following first recurrence, underscoring the life-threatening impact…
Source →Robotic-Assisted Early Repair of Vesicovaginal Fistula in a Colon Cancer Patient: A Case Report and Surgical Technique Video.
Patel DS, et al
A multidisciplinary robotic-assisted repair of vesicovaginal fistula (VVF) performed just 6 weeks after oncologic surgery in a colon cancer patient resulted in successful fistula closure with no recurrence at 2 years, allowing timely initiation of adjuvant chemotherapy. The transperitoneal extravesi…
Source →Immunogenicity and safety of prophylactic HPV vaccines in people living with HIV: A systematic review and meta-analysis.
Senel B, et al
A systematic review and meta-analysis of 25 studies (12 included in quantitative synthesis, N = 1,493 for HPV16) found that prophylactic HPV vaccines achieve high pooled seroconversion rates in people living with HIV, reaching 97.8% (95% CI: 94.9–99.1%) for HPV16, 94.2% (95% CI: 86.1–97.7%) for HPV1…
Source →Mapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.
Yadav A, et al
A new computational framework called PathStAR, applied to 25,306 post-mortem biopsies from 40 tissues in 970 donors aged 21–70 years, has revealed that human organs age structurally along distinct, nonlinear trajectories rather than deteriorating uniformly over time. Vascular tissue structural aging…
Source →Dual-tracer 18F-FDG and 18F-FLT PET/CT for differentiating metastatic lymph nodes from sarcoid involvement in a patient with vulvar squamous cell carcinoma and coexisting pulmonary sarcoidosis.
Tsuchiya J, et al
A dual-tracer PET/CT strategy combining 18F-FDG and 18F-FLT successfully differentiated a confirmed metastatic lymph node from sarcoid-related lymphadenopathy in a 75-year-old woman with vulvar squamous cell carcinoma and coexisting pulmonary sarcoidosis. The malignant right groin node showed near-i…
Source →French multicentre randomised phase III trial evaluating the efficacy and safety of vaginal radiofrequency in the management of vulvovaginal atrophy and dryness in patients treated for breast cancer (RF-Vaginale): trial protocol.
Demetz J, et al
The RF-Vaginale trial protocol describes a French multicentre randomised phase III study designed to evaluate whether vaginal radiofrequency (RF) treatment can reduce vaginal dryness in breast cancer patients for whom standard non-hormonal moisturising therapy has proved insufficient, addressing a c…
Source →"Fibrosarcoma-like" Tumors of the Gynecologic Tract Show Distinct Molecular Subgroups: Tyrosine Kinase Fusions and Recurrent ERBB2/3 Mutations.
Marshall EH, et al
A study of 17 rare fibrosarcoma-like tumors of the gynecologic tract has identified two distinct molecular subgroups: tyrosine kinase gene fusions, found in 9 tumors (including 6 with NTRK fusions and 3 with COL1A1::PDGFB), and oncogenic ERBB2/ERBB3 variants, found in 6 additional tumors, each subgr…
Source →Morphology and Beyond - A Rare Case of Metastatic Succinate Dehydrogenase-Deficient Paraganglioma of the Vulva.
Kshirsagar SP, et al
A 35-year-old woman with a prior history of pheochromocytoma was diagnosed with metastatic succinate dehydrogenase-deficient (SDH-deficient) paraganglioma of the vulva — an exceptionally rare tumor location that posed significant diagnostic challenges due to morphological overlap with other nested n…
Source →Molecular subtypes of stage III vulvar squamous cell carcinoma predict recurrence and survival outcomes.
Warring SK, et al
HPV-independent vulvar squamous cell carcinoma with TP53 mutation (HPV-/p53mut) is associated with a 5.7-fold increased risk of disease-specific death compared with HPV-associated tumors (HR 5.70, 95% CI 1.66–19.62), according to a retrospective study of 52 stage III patients treated at a single ins…
Source →Research progress on HPV-related vaginal wall lesions after hysterectomy.
Zhang D, et al
A systematic review published in Frontiers in Oncology highlights that vaginal intraepithelial neoplasia (VaIN) — although accounting for less than 1% of all lower genital tract precancerous lesions — occurs at a significantly elevated rate in women who have undergone hysterectomy for cervical intra…
Source →Friend or foe: divergent immunomodulatory effects of metabolites derived from the virucidal zinc finger inhibitor SAMT-247.
Woode EK, et al
A new study published in Frontiers in Immunology reveals that Met-D, the predominant SAMT-247 metabolite found in vaginal tissue, most faithfully recapitulates and reinforces the protective immune profile of the parent compound by expanding IL-17+NKp44+ innate lymphoid cells (ILCs), CD107a+NKG2A+ na…
Source →HPV52 predominates in cervical infections and precancerous lesions in Chongqing, China: a 6-year study linking genotypes to vaginal microecology.
Li X, et al
A six-year study of 24,050 women in Chongqing, China found that HPV52 is the dominant cervical genotype, accounting for 19.9% (690/4,375) of single infections and 11.2% (493/4,418) of multiple infections, outranking HPV16 and HPV53 across the cohort. The overall HPV detection rate was 21.7% (5,211/2…
Source →The implications and mechanisms of vaginal microbiota metabolites on cervical cancer progression.
Wang W, et al
A new review synthesizes evidence that metabolites produced by the vaginal microbiota are critical mediators linking the microbial ecosystem of the female reproductive tract to cervical cancer initiation and progression, acting through at least three distinct mechanisms: regulating high-risk HPV per…
Source →Case Report: Persistent urogenital sinus (PUGS) associated with complete bicorporeal uterus, double cervix and partial longitudinal non-obstructing vaginal septum: a one-stop diagnostic and operative hysteroscopic approach.
Bonetti Palermo E, et al
A 39-year-old nulliparous woman with chronic pelvic pain, dyspareunia, and recurrent urogenital infections was successfully diagnosed and treated via a one-stop approach combining transvaginal ultrasound and hysteroscopy, revealing persistent urogenital sinus (PUGS) associated with a complete bicorp…
Source →Case report of epithelioid sarcoma of the vulva.
Chen F, et al
A case report published in Frontiers in Medicine describes a 56-year-old woman whose proximal-type vulvar epithelioid sarcoma — an extremely rare malignant mesenchymal tumor accounting for less than 1% of all sarcomas — was misdiagnosed and treated as a benign vulvar abscess across multiple hospital…
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