Urethra
Recurrent Perineal Urethral Squamous Cell Carcinoma Multidisciplinary Approach.
Farzat M, et al
A multidisciplinary surgical team achieved complete tumour clearance (R0 resection) in a 56-year-old male with extensive perineal recurrence of urethral squamous cell carcinoma following radical penectomy, using robot-assisted radical cystoprostatovesicourethrectomy with en bloc perineal tumour exci…
Source →De Novo and Postradiation Adenocarcinoma of the Urethra: A Clinicopathologic and Radiologic Study of 55 Cases.
Zhang M, et al
A clinicopathologic and radiologic study of 55 patients with primary urethral adenocarcinoma identified two distinct disease subtypes — de novo adenocarcinoma (n=45) and postradiation adenocarcinoma (n=10) — with a mean disease-specific survival of 100.35 months and similar Kaplan-Meier survival pat…
Source →Primary malignant melanoma of the female urethra: a case report and literature review.
Xie J, et al
A case report from Gansu Provincial Hospital documents a successful individualized surgical approach for primary malignant melanoma of the female urethra, an extremely rare and aggressive mucosal malignancy, in an 81-year-old Chinese patient who presented with a black mass at the external urethral m…
Source →Bladder, Penis, and Urethral Cancer and Basic Principles of Oncology.
Ritch CR
A comprehensive review published in The Journal of Urology addresses the foundational oncological principles underlying bladder, penile, and urethral cancers, providing clinicians with an integrated framework for understanding disease biology, staging, and treatment rationale across these urological…
Source →Automatic treatment planning using reinforcement learning for high-dose-rate prostate brachytherapy.
Wang T, et al
A reinforcement learning (RL) agent has been shown for the first time to autonomously generate clinically acceptable treatment plans for high-dose-rate (HDR) prostate brachytherapy, reducing rectal dose (Rectum D2cc) by 3.5%, urethral dose (Urethra D20%) by 2%, and high-dose prostate volume (Prostat…
Source →Case Report: Persistent urogenital sinus (PUGS) associated with complete bicorporeal uterus, double cervix and partial longitudinal non-obstructing vaginal septum: a one-stop diagnostic and operative hysteroscopic approach.
Bonetti Palermo E, et al
A 39-year-old nulliparous woman with chronic pelvic pain, dyspareunia, and recurrent urogenital infections was successfully diagnosed and treated via a one-stop approach combining transvaginal ultrasound and hysteroscopy, revealing persistent urogenital sinus (PUGS) associated with a complete bicorp…
Source →Solitary fibrous tumour mimicking a urethral caruncle: a diagnostic pitfall.
Ono Y, et al
A rare solitary fibrous tumour (SFT) was successfully diagnosed and treated after it presented as a urethral caruncle — the most common benign lesion at the urethral meatus — in a woman in her late 60s, highlighting a significant diagnostic pitfall for clinicians. The 1.2 cm smooth spherical mass wa…
Source →Incidence of Germline Genetic Variants in Patients with a Urinary Tract Cancer and Association with Outcomes.
Kamau K, et al
A new study found that 9.3–9.5% of unselected patients with urinary tract cancer (UTC) harbor pathogenic or likely pathogenic germline variants in cancer predisposition genes, and current clinical guidelines miss more than one-third of these carriers. The retrospective study analyzed 273 patients an…
Source →Urethral Metastasis of Therapy-Induced Neuroendocrine Prostate Cancer Successfully Managed With Chemoradiotherapy: A Case Report.
Kayaba T, et al
Platinum-based chemoradiotherapy achieved durable local control of urethral metastasis from therapy-induced neuroendocrine prostate cancer (t-NEPC) in a 72-year-old man who survived 2 years and 10 months despite later distant progression. The patient had been diagnosed with prostate adenocarcinoma 1…
Source →Conceptualizing the "High" Bladder Neck - Anatomic Rabbit Hole or Functional Gold Mine?
Kaufman MR, et al
A perspective published in European Urology Focus concludes that the concept of a 'high bladder neck' is neither standardized nor supported by an adequate evidence base in diagnostics or therapy, yet bladder neck incision continues to be used as a first-line treatment. Recent systematic reviews have…
Source →Urologic Oncology: Bladder, Penis, and Urethral Cancer and Basic Principles of Oncology.
Ritch CR
This publication presents a comprehensive review of urologic oncology covering bladder, penile, and urethral cancers alongside foundational principles of oncology, as published in The Journal of Urology. The work consolidates current clinical and scientific knowledge on these malignancies to serve a…
Source →Sex Differences in Urinary Extracellular Vesicles Originating from the Genitourinary System in Health and Disease.
Pantham P, et al
A state-of-the-art review highlights that urinary extracellular vesicles (uEVs) — lipid bilayer-bound particles shed into urine by organs of the genitourinary system — differ substantially between males and females in their molecular cargo, yet the vast majority of clinical uEV studies have been con…
Source →The Role of Artificial Neural Networks in Prostate Magnetic Resonance Imaging (MRI) Segmentation.
Shori P, et al
A retrospective study of 31 prostate cancer patients found that AI-generated MRI segmentation achieved a Dice similarity coefficient of 0.875 against urologist contours for the whole-gland prostate, outperforming both the AI-to-radiologist comparison (0.757) and the urologist-to-radiologist agreemen…
Source →Multimodal Treatment for Female Primary Urethral Carcinoma: A Three-Case Series Utilizing Robot-Assisted Radical Cystectomy and Extended Resection.
Oishi Y, et al
A three-case series of female patients with locally advanced primary urethral carcinoma (PUC) treated with robot-assisted radical cystectomy (RARC) and extended surgical resection showed that individualized multimodal therapy can achieve meaningful disease control, with one patient attaining a patho…
Source →Efficacy evaluation of urethral dragging-and-adhesion anastomosis in ileal orthotopic neobladder reconstruction following laparoscopic radical cystectomy: a dual-center retrospective study.
Xu LY, et al
A modified urethral dragging-and-adhesion anastomosis technique significantly reduced total operative time (279.80 ± 45.32 min vs. 382.60 ± 45.94 min, p < 0.01), urethral anastomosis time (18.37 ± 7.05 min vs. 61.80 ± 11.35 min, p < 0.01), and intraoperative blood loss (274.00 ± 85.48 mL vs. 336.80 …
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