Peritoneum & Retroperitoneum
[18F]AlF-FAPI-74 PET/CT for preoperative assessment of the peritoneal cancer index and comparison with MRI-based, surgical and pathological assessment in colorectal cancer patients eligible for CRS-HIPEC: study protocol for a prospective observational proof-of-concept study.
van den Bos M, et al
The TROMPET study is a prospective observational proof-of-concept trial enrolling 25 colorectal cancer patients with suspected or confirmed peritoneal metastases who are candidates for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), designed to determine whether [1…
Source →Extraskeletal Ewing Sarcoma Involving the Abdominal Cavity and Retroperitoneum on 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT.
Lei Q, et al
A case report published in Clinical Nuclear Medicine describes the imaging characteristics of a rare primary extraosseous Ewing sarcoma located in the abdominal cavity and retroperitoneum, a site that is exceptionally uncommon for this tumour type. The mass exhibited only mild uptake on standard 18F…
Source →A Self-Assembling Janus Dendron-Modified Phthalocyanine Enables Deep Tumor-Targeted Therapy for Gastric Cancer Peritoneal Metastases.
Guo J, et al
Researchers have developed TT1-4PYR, a self-assembling Janus dendron-modified phthalocyanine nanoparticle that achieves deep penetration and selective accumulation within peritoneal metastasis lesions of gastric cancer, enabling potent photodynamic therapy (PDT). The compound harnesses an ascites-de…
Source →Robotic cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy for selected appendiceal neoplasms: Early experience from a national referral centre.
Arora P, et al
A national referral centre has demonstrated that robotic cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (RCRS-HIPEC) is feasible and safe in eight carefully selected patients with high-risk appendiceal neoplasms — comprising low-grade appendiceal mucinous neoplasm (n=3…
Source →Small Bowel Cancer: Implications of Preoperative Work-Up on Surgical Strategy.
Kjæstad E, et al
A retrospective single-center study of 187 operations for suspected small bowel cancer found that preoperative diagnostic workup correctly identified the tumor entity in only 118 of 187 (63%) cases, with CT scanning showing critically poor sensitivity for peritoneal metastases at just 9% and for mes…
Source →Primary Breast Involvement in Erdheim-Chester Disease: A Rare Presentation.
Morkos K, et al
A case report published in Case Reports in Radiology documents a rare presentation of Erdheim-Chester disease (ECD) — a multisystem histiocytic neoplasm — with primary breast involvement in a 40-year-old woman who experienced 5 years of breast enlargement and pigmentation, with disease also affectin…
Source →[Application of transformer in intelligent diagnosis and treatment of peritoneal metastasis: current status and prospects].
Zou PR, et al
A systematic review published in the Chinese Journal of Gastrointestinal Surgery concludes that Transformer deep-learning models show meaningful early promise for improving imaging diagnosis, pathological and molecular subtyping, and prognosis prediction in peritoneal metastasis — a common and diffi…
Source →Transcriptome differences in lesions by color, and cancer mutations in endometriosis.
Huang JY, et al
A study using bulk RNA sequencing found that somatic mutations in cancer-associated genes ARID1A, KRAS, PIK3CA, ARHGAP35, and PBRM1 occur not only in endometriotic lesions but also in the surrounding peritoneum and eutopic endometrium of patients with endometriosis who do not have cancer, suggesting…
Source →Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for pancreatic cancer peritoneal metastases: A retrospective multicentric study from the ISSPP PIPAC Database.
Di Giorgio A, et al
A multicentric retrospective study of 156 patients treated with 350 PIPAC (pressurized intraperitoneal aerosol chemotherapy) procedures across 6 centers found that PIPAC is a safe locoregional option for pancreatic ductal adenocarcinoma peritoneal metastases, with no major surgical complications (Cl…
Source →Real-World Efficacy and Safety of Belzutifan in Sporadic Metastatic Renal Cell Carcinoma.
Li YJ, et al
A real-world multicenter retrospective study of 43 heavily pre-treated metastatic renal cell carcinoma patients found that belzutifan achieved an objective response rate of 25% (9 partial responses), a median progression-free survival of 5.7 months (95% CI, 3.3–10.7), and a median overall survival t…
Source →Leiomyosarcoma survival across anatomical sites identifies high- and low-risk patient groups to inform clinical trial design.
Oswald AJ, et al
A major study of 11,751 leiomyosarcoma patients found stark survival disparities across anatomical sites and patient demographics, with the uterus (36.3%), limbs (16.6%), superficial trunk (10.8%), and retroperitoneum (9.2%) being the most common sites over a median follow-up of 8.4 years. Multivari…
Source →The Potential Role of 99mTc-FAPI SPECT/CT in the Staging of Mucinous Appendiceal Adenocarcinoma.
Rezaei Borujerdi N, et al
A case report published in Clinical Nuclear Medicine demonstrates that 99mTc-FAPI SPECT/CT successfully identified widespread skeletal metastases and extensive soft-tissue involvement in the peritoneum, appendiceal region, and pleura in a 55-year-old woman with mucinous appendiceal adenocarcinoma — …
Source →Great peritoneal pretenders: imaging mimickers of peritoneal carcinomatosis.
Jose J, et al
A comprehensive review in Abdominal Radiology warns that numerous benign and malignant conditions — including inflammatory, infectious, traumatic, iatrogenic, and non-carcinomatous malignant processes — can produce imaging findings indistinguishable from peritoneal carcinomatosis (PC), a metastatic …
Source →Oligometastatic GIST: Impact of Treatment Modalities and Metastatic Distribution on Overall Survival.
Pearce WH, et al
A retrospective cohort study of 96 oligometastatic GIST patients found that cytoreductive surgery combined with systemic therapy was associated with significantly longer overall survival compared to systemic therapy alone (10.8 vs. 7.4 years; HR: 0.44; 95% CI, 0.22–0.89; p = 0.019). Oligometastatic …
Source →Comparison of Two Specimen-Extraction-Site Loop Ileostomy Construction Strategies After Laparoscopic Low Anterior Resection: A Retrospective Study.
Liu Q, et al
A retrospective study of 419 rectal cancer patients found that two specimen-extraction-site (SES) loop ileostomy construction strategies — nonsuturing of the peritoneum-rectus sheath with support-rod placement (Group A, n=256) versus peritoneum-rectus sheath suturing without support-rod placement (G…
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