Rare Malignant Breast Tumours
Prognosis
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🔬 Histological Types
📚 Latest Research
Spindle Cell Lesions of the Breast: A 12-Year Experience.
Jassal S, et al
A 12-year single-centre study of 30 breast spindle cell lesions found that atypical spindle cell lesions (ASCL) carry a very high malignancy risk: 80% of the 10 ASCLs excised proved malignant, comprising sarcoma (n=1), malignant phyllodes tumour (n=3), and metaplastic cancer (n=4). By contrast, none of the 11 bland spindle cell lesions (BSCL) that underwent excisional biopsy were malignant, suggesting that low-risk BSCLs may safely be managed with radiological and clinical surveillance rather than immediate surgery. The findings underscore the importance of histological subclassification on core biopsy and a multidisciplinary team approach to guide management of these rare and diagnostically challenging breast pathologies.
ANZ journal of surgery
Source →An Agreement Study of Stromal Cellularity, Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast.
Li X, et al
A landmark interobserver agreement study involving 19 subspecialized breast pathologists found only moderate agreement when classifying key morphologic features of phyllodes tumors, even after structured virtual training. Using Krippendorff's alpha and Fleiss's kappa, pre-training agreement on stromal cellularity was moderate (α=0.727 ordinal; κ=0.675 binary), agreement on stromal cell atypia was poor in ordinal assessment (α=0.570) but moderate in binary assessment (κ=0.446), and agreement on tumor border was moderate (κ=0.532). After training, tumor border agreement improved to κ=0.615, while cellularity and atypia scores changed minimally, and 15 of 19 pathologists shifted toward more conservative cellularity ratings. These findings highlight a persistent diagnostic challenge in classifying fibroepithelial breast lesions and underscore the need for refined, standardized criteria to improve consistency in clinical practice.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Source →Bilateral breast metastatic rectal cancer with MET gene amplification: A rare case report.
Nguyen DT, et al
A rare case report documents bilateral breast metastases originating from rectal cancer in a woman in her early 50s, with MET gene amplification identified as a key genetic finding — a combination so uncommon that breast metastases from colorectal cancer account for less than 0.5% of all malignant breast lesions. The patient was initially diagnosed with cT3N2M0 rectal cancer in April 2023, underwent Miles surgery, 12 cycles of mFOLFOX6 adjuvant chemotherapy, and chemoradiation (50.4 Gy plus Capecitabine), before bilateral breast lesions and peritoneal metastases were discovered just seven months after discharge in January 2024. Despite multiple treatment regimens, the disease progressed rapidly and the patient died six months after recurrence was detected, underscoring that breast metastases represent a grave prognostic indicator in colorectal cancer. Clinicians are urged to pursue careful differential diagnosis in any patient presenting with malignant breast lesions and a prior history of non-breast malignancy.
Rare tumors
Source →💊 Therapies
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🧪 Tumor markers
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