Rare Malignant Breast Tumours
Spindle Cell Lesions of the Breast: A 12-Year Experience.
Jassal S, et al
A 12-year single-centre study of 30 breast spindle cell lesions found that atypical spindle cell lesions (ASCL) carry a very high malignancy risk: 80% of the 10 ASCLs excised proved malignant, comprising sarcoma (n=1), malignant phyllodes tumour (n=3), and metaplastic cancer (n=4). By contrast, none…
Source →An Agreement Study of Stromal Cellularity, Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast.
Li X, et al
A landmark interobserver agreement study involving 19 subspecialized breast pathologists found only moderate agreement when classifying key morphologic features of phyllodes tumors, even after structured virtual training. Using Krippendorff's alpha and Fleiss's kappa, pre-training agreement on strom…
Source →Bilateral breast metastatic rectal cancer with MET gene amplification: A rare case report.
Nguyen DT, et al
A rare case report documents bilateral breast metastases originating from rectal cancer in a woman in her early 50s, with MET gene amplification identified as a key genetic finding — a combination so uncommon that breast metastases from colorectal cancer account for less than 0.5% of all malignant b…
Source →Immunohistochemical and Molecular Features Distinguishing Metaplastic Breast Carcinoma With Squamous Differentiation From Cutaneous Squamous Cell Carcinoma.
Rutland CD, et al
A new study identifies a panel of immunohistochemical and molecular markers that can reliably distinguish metaplastic breast carcinoma (MBC) with squamous differentiation from cutaneous squamous cell carcinoma (cSCC) arising in breast or chest skin — a diagnostically challenging and clinically criti…
Source →Primary Mammary Angiosarcoma in a Postmenopausal Woman: A Case Report.
Liu T, et al
A 51-year-old postmenopausal woman with a rapidly enlarging left breast mass was diagnosed with stage I (T1N0M0) primary breast angiosarcoma and achieved no recurrence or metastasis over more than 5 years of follow-up after radical two-stage surgical resection followed by sequential adjuvant chemoth…
Source →A Case of Concurrent Liver Metastases from Colorectal and Breast Cancer Diagnosed Using Percutaneous Tumor Biopsy.
Yusa T, et al
Clinicians successfully diagnosed concurrent liver metastases from two separate primary cancers — colorectal and breast cancer — in a single 71-year-old patient using percutaneous tumor biopsy with immunohistochemistry, a rare and diagnostically challenging scenario. The patient had been receiving C…
Source →Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.
Dou G, et al
Researchers engineered pyroptosis-amplified decoy nanovesicles (PADVs) that simultaneously neutralize immune checkpoints and trigger controlled tumor cell death (pyroptosis), demonstrating potent suppression of tumor progression, recurrence, and metastasis across melanoma, breast cancer, and colon c…
Source →Primary adenoid cystic carcinoma of the breast: a clinicopathological case series.
Kaur B, et al
A retrospective case series of three histologically confirmed primary adenoid cystic carcinomas of the breast (ACCB) — a rare malignancy accounting for fewer than 0.1% of breast cancers — found no recurrence or metastasis in any patient following surgical excision with clear margins, confirming the …
Source →Primary Breast Involvement in Erdheim-Chester Disease: A Rare Presentation.
Morkos K, et al
A case report published in Case Reports in Radiology documents a rare presentation of Erdheim-Chester disease (ECD) — a multisystem histiocytic neoplasm — with primary breast involvement in a 40-year-old woman who experienced 5 years of breast enlargement and pigmentation, with disease also affectin…
Source →Cholesterol metabolism dysregulation in eyelid sebaceous gland carcinoma and its clinical significance.
Rafat S, et al
A new study of 50 eyelid sebaceous gland carcinoma (SGC) patients found that the cholesterol-metabolizing enzyme ACAT1 was overexpressed in 66% of cases, and its high expression was significantly associated with lymph node metastasis (P = 0.03) and advanced tumor stage III/IV (P = 0.02). Researchers…
Source →Pulmonary sclerosing pneumocytoma masquerading as lung metastasis: A case report.
Kim MY, et al
A 42-year-old woman with a history of breast cancer was found to have a 1.6-cm juxtapleural lung mass that displayed apparent vessel abutment and suspected vascular invasion on contrast-enhanced CT, leading radiologists to suspect angioinvasive metastasis, yet histopathological examination after ope…
Source →HER2 Intratumoral Heterogeneity in Salivary Duct Carcinoma: Association With Treatment Response and Comparison Between Primary and Metastatic Lesions.
Utsumi Y, et al
In the largest cohort to date of 98 patients with unresectable HER2-positive salivary duct carcinoma (SDC) treated with trastuzumab plus docetaxel, HER2 intratumoral heterogeneity (ITH) — identified in 11.2% of cases — was not associated with treatment response or survival, suggesting that its prese…
Source →Occult Breast Carcinoma Presenting with Extensive Bone Involvement in the Absence of an Identifiable Primary Breast Lesion: A Case Report.
Huang S, et al
A rare case of occult breast cancer (OBC) presenting with diffuse osteolytic bone metastases and axillary lymphadenopathy — with no detectable primary breast lesion on clinical examination, mammography, or ultrasound — was definitively diagnosed through bone marrow biopsy and immunohistochemical ana…
Source →Clinical case giant malignant phyllodes tumor of the breast.
Amaya AH, et al
A 56-year-old woman in Peru with a giant malignant phyllodes tumor of the left breast was successfully treated with total mastectomy, margin extension, and partial-thickness skin grafting, achieving complete tumor resection and satisfactory recovery. The aggressive tumor measured 12 cm on ultrasound…
Source →Ultrasound Features as Adjunctive Predictors of Pathological Grade in Phyllodes Tumors of the Breast: An Imaging-Pathology Correlation Study.
Zhang H, et al
A study of 78 patients with phyllodes tumors of the breast found that five specific ultrasound features — tumor size greater than 3.55 cm, irregular shape, wavy margins, calcification, and internal cystic areas — significantly distinguish borderline from benign tumors, with a combined imaging model …
Source →