Latest Research
All publications from the Cancer3.AI database, newest first.
Correction: Mature B, T and NK-cell, plasma cell and histiocytic/dendritic cell neoplasms: classification according to the World Health Organization and International Consensus Classification.
Ferry JA, et al
This publication is a formal correction to a previously published classification article addressing mature B-cell, T-cell, natural killer (NK)-cell, plasma cell, and histiocytic/dendritic cell neoplasms as defined by the World Health Organization (WHO) and the International Consensus Classification (ICC). Such classification frameworks are essential tools for oncologists and pathologists, as they provide standardized criteria for diagnosing and categorizing blood and lymph node cancers. The correction ensures that clinicians and researchers working with these guidelines have access to accurate, up-to-date information when making diagnostic and treatment decisions. While corrections are routine in scientific publishing, maintaining precision in cancer classification documents is particularly important given their direct impact on patient care pathways. The Journal of Hematology and Oncology published this erratum to uphold the integrity of the original reference material.
Journal of hematology & oncology
Source →A Case of Breast Papillary Carcinoma in an Elderly Black Male Patient With Pathology, Ultrasound, and Mammogram Imaging Findings.
Kent T, et al
Researchers from Cureus journal report a rare case of breast papillary carcinoma diagnosed in an 84-year-old Black male patient, a demographic in which this cancer type is exceptionally uncommon. The patient presented with a palpable left breast mass, which was evaluated using ultrasound, mammography, and ultrasound-guided core needle biopsy. Imaging revealed a complex cystic mass on ultrasound and a well-circumscribed, high-density lesion on mammogram, while immunostaining showed an absence of myoepithelial cells within fibrovascular cores, a hallmark finding of papillary carcinoma. This case report contributes to the limited medical literature documenting male breast papillary carcinoma, helping clinicians recognize the characteristic imaging and pathological features of this rare presentation. Awareness of this condition in elderly male patients is clinically important, as delayed diagnosis due to low suspicion can negatively impact treatment outcomes.
Cureus
Source →Mature B, T and NK-cell, plasma cell and histiocytic/dendritic cell neoplasms: classification according to the World Health Organization and International Consensus Classification.
Ferry JA, et al
This review article examines and compares two major international classification systems for lymphoid cancers published in 2022: the World Health Organization's fifth edition classification (WHO-HAEM5) and the International Consensus Classification (ICC). Both systems cover mature B-cell, T-cell, NK-cell, plasma cell, and histiocytic/dendritic cell neoplasms, and were developed by panels of expert pathologists and clinicians using data-driven consensus processes. While both classifications share the same foundational framework rooted in the revised fourth edition WHO classification, they differ in specific areas of terminology and preferred approaches to certain unresolved disease categories. The review highlights these similarities and differences to help clinicians and pathologists navigate the two systems when diagnosing and managing patients with lymphoid malignancies. Having clarity on classification differences is critical for ensuring consistent diagnosis, clinical trial enrollment, and treatment decisions across institutions worldwide.
Journal of hematology & oncology
Source →Glioma.
Weller M, et al
A comprehensive review published in Nature Reviews Disease Primers examines gliomas, the most common primary brain tumors, which are believed to originate from neural stem or progenitor cells harboring cancer-initiating genetic mutations. The review details how gliomas are classified under the WHO central nervous system tumor classification system into grades 1 through 4, with adult diffuse gliomas divided into three distinct subtypes: IDH-mutant oligodendrogliomas with the best prognosis, IDH-mutant astrocytomas with intermediate outcomes, and IDH-wild-type glioblastomas with the poorest survival rates. In children, pilocytic astrocytoma is the most common and generally favorable glioma, while histone 3 K27-altered diffuse midline glioma represents the leading cause of glioma-related death in pediatric patients. The review also covers ependymal tumors, which are now classified into biologically distinct subtypes based on histology, molecular markers, and tumor location. Current standard treatment relies on surgery, radiotherapy, and chemotherapy, but the review highlights how individually tailored therapies targeting dominant tumor signaling pathways have begun to improve outcomes for specific patient subgroups. This primer provides clinicians and researchers with an up-to-date framework for understanding glioma biology, classification, and treatment, underscoring the critical role of molecular profiling in guiding modern neuro-oncology care.
Nature reviews. Disease primers
Source →Consensus guidelines for the management of primary supra-tentorial intraventricular tumour for low- and middle-income countries.
Aziz HF, et al
A new set of consensus guidelines has been published addressing the diagnosis and management of primary supratentorial intraventricular brain tumors, with a particular focus on settings in low- and middle-income countries (LMICs). Intraventricular tumors encompass a wide variety of lesions — including ependymomas, central neurocytomas, choroid plexus tumors, and meningiomas — that arise within or grow into the brain's ventricular system, often presenting with vague, nonspecific symptoms that can delay diagnosis. The guidelines highlight that the deep anatomical location of these tumors and the diversity of possible diagnoses create substantial challenges for neurosurgeons and oncologists. A key recommendation is the adoption of a multidisciplinary care approach, integrating neurosurgery, oncology, radiology, and pathology to improve patient outcomes. The paper is especially significant for clinicians working in resource-limited environments, where access to advanced imaging, surgical infrastructure, and adjuvant therapies may be restricted. By standardizing management strategies, these guidelines aim to reduce variability in care and improve survival and quality of life for patients with these rare but complex brain tumors.
JPMA. The Journal of the Pakistan Medical Association
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