Latest Research
All publications from the Cancer3.AI database, newest first.
Pullulan-based nanofiber membranes with antibacterial and anti-inflammatory properties for rhinosinusitis therapy.
Elnahas H, et al
Researchers developed a novel nanofiber membrane platform designed to treat rhinosinusitis, a common and often painful inflammation of the nasal sinuses that frequently requires both antibiotic and anti-inflammatory treatment. The team used a scalable manufacturing technique called Forcespinning® to create membranes from pullulan, a natural polysaccharide, loaded with both ampicillin (an antibiotic) and clove oil (a natural anti-inflammatory agent). Laboratory testing showed that the combined nanofibers were significantly more effective at killing Staphylococcus aureus bacteria than either agent used alone, and the membranes were non-toxic to cells at concentrations up to 500 µg/mL. The nanofibers also markedly reduced inflammatory signaling in immune cells and demonstrated favorable interaction with nasal mucus, supporting their potential for effective drug delivery directly to the nasal lining. These findings suggest that pullulan-based nanofiber membranes could provide a noninvasive, localized treatment option for rhinosinusitis patients, potentially reducing the need for systemic antibiotics and their associated side effects.
Therapeutic delivery
Source →Metastatic castrate-resistant prostate cancer to the penis resulting in malignant priapism and urethral obstruction.
Stewart C, et al
Researchers report an exceptionally rare case of metastatic castrate-resistant prostate cancer spreading to the penis and urethra in a 76-year-old man, detected using a PSMA PET scan. The metastatic deposits caused malignant priapism — a persistent, painful erection due to blocked blood flow through the erectile tissue — as well as urinary obstruction. To relieve his symptoms and improve quality of life, the patient underwent radical penectomy, partial urethrectomy, and creation of a perineal urethrostomy, with final pathology confirming prostatic adenocarcinoma. This case highlights that prostate cancer, though rarely, can spread to the penile corpora cavernosa or spongiosum, a complication that clinicians should be aware of in advanced disease. The authors conclude that surgical excision combined with urinary diversion currently offers the most durable relief for patients facing this devastating complication.
Urology case reports
Source →Single-organ vasculitis of the uterine cervix mimicking cervical cancer: A case report.
Kusakabe H, et al
A rare case report published in Case Reports in Women's Health describes a 22-year-old woman whose cervical mass was initially suspected to be advanced cervical cancer based on imaging, cytology, and clinical presentation, but was ultimately diagnosed as single-organ vasculitis of the uterine cervix. The 5 cm mass, accompanied by enlarged lymph nodes and cytological findings of atypical glandular cells, created a compelling but ultimately incorrect picture of adenocarcinoma; however, histopathological examination revealed necrotizing vasculitis with fibrinoid necrosis rather than malignancy. Remarkably, the mass resolved spontaneously without any treatment during follow-up, though cytological abnormalities persisted, underscoring the limitations of cytology alone in distinguishing severe inflammation from cancer. This appears to be the first reported case of spontaneously resolving cervical single-organ vasculitis mimicking adenocarcinoma, and it carries an important clinical message: tissue biopsy and careful clinicopathological correlation are essential before proceeding with radical interventions, especially in young women where preserving fertility is a priority.
Case reports in women's health
Source →Gigantism.
Donato S, et al
This review article, published in the journal Vitamins and Hormones, provides a comprehensive update on gigantism — a condition defined by height more than two standard deviations above the average for a person's age, sex, and ethnicity. The authors focus primarily on pituitary gigantism, which is driven by excessive levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and outline the wide spectrum of causes ranging from genetic mutations (such as AIP and MEN1) to constitutional growth variants and rare overgrowth syndromes. The review emphasizes that while most cases of tall stature stem from benign, non-hormonal causes, endocrine disorders must be systematically excluded because they carry specific treatments and genetic implications for families. Clinicians are guided through differential diagnosis and management strategies, including consideration of both isolated and familial forms of pituitary gigantism. This work is particularly important for endocrinologists and pediatricians who encounter children or adolescents with unusually rapid or tall growth, as early diagnosis of hormonal causes can significantly improve patient outcomes.
Vitamins and hormones
Source →Integrative Oncology Approach in Advanced Myxofibrosarcoma: A Case Report of Prolonged Survival with High-Dose Vitamin C and Viscum album.
Gigineishvili D, et al
Researchers report the case of a 59-year-old man diagnosed with high-grade myxofibrosarcoma (MFS), a rare and aggressive soft tissue cancer, who developed unresectable tumors in his right buttock along with spinal metastases. In addition to standard palliative treatments including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the patient received high-dose intravenous vitamin C and mistletoe (Viscum album) extracts administered intravenously, subcutaneously, and directly into the tumor. Despite disease progression and a COVID-19 infection during treatment, the patient survived 48 months — roughly double the median survival of 12 to 24 months typically reported for advanced MFS. The authors suggest that integrative oncology approaches combining conventional anticancer treatments with high-dose vitamin C and mistletoe extracts may improve treatment tolerance and potentially extend survival in this difficult-to-treat cancer. While this single case cannot establish causality, it adds to growing interest in complementary therapies as adjuncts in sarcoma care and calls for larger prospective studies to rigorously evaluate these interventions.
Case reports in oncology
Source →