Latest Research
All publications from the Cancer3.AI database, newest first.
[Untargeted metabolomics reveals therapeutic mechanism of Fuzi Lizhong Pills on oxazolone-induced ulcerative colitis in mice].
Li Y, et al
Researchers investigated the therapeutic mechanism of Fuzi Lizhong Pills (FLP), a traditional Chinese herbal medicine, using a mouse model of acute ulcerative colitis (UC) induced by oxazolone sensitization and rectal enema challenge. After seven days of FLP treatment, mice showed significant improvement in clinical symptoms including weight loss, diarrhea, and rectal bleeding, alongside restoration of colon length and repair of tissue damage such as mucosal hyperemia, edema, and inflammatory cell infiltration. At the molecular level, FLP substantially reduced expression of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in colon tissue, and helped restore the functional balance of immune organs including the spleen and thymus. Untargeted fecal metabolomics analysis revealed that FLP normalized 126 dysregulated metabolites, primarily through pathways involving nicotinate and nicotinamide metabolism, propanoate metabolism, and phenylalanine metabolism. These findings demonstrate that FLP combats UC by simultaneously suppressing immune-inflammatory responses and correcting underlying metabolic disorders, providing scientific evidence that may support broader clinical consideration of this traditional remedy for inflammatory bowel disease management.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Source →Investigating the Relationship Human Parvovirus B19 Infection in Benign and Malignant Salivary Gland Tumors.
Farhadi A, et al
A research team from Shiraz Dental School and two major referral hospitals in Iran investigated whether Human Parvovirus B19, a widely circulating virus known to affect immunocompromised individuals and linked to various cancers and autoimmune disorders, is present in salivary gland tumors. Using a highly sensitive nested-PCR technique, researchers tested 71 formalin-fixed, paraffin-embedded tissue specimens from patients with both benign and malignant salivary gland tumors, along with 30 normal salivary gland tissue samples as controls. The study found that B19 viral DNA was detected in 15.5% of tumor specimens, while none of the normal salivary gland samples tested positive, a difference that was statistically significant (p=0.031). Notably, the presence of the virus showed no significant association with patient age, sex, tumor location, or whether the tumor was benign or malignant. These findings suggest that Parvovirus B19 may be associated with salivary gland tumor development regardless of tumor type, pointing to a potential viral component in salivary gland tumorigenesis that warrants further investigation into viral mechanisms and possible clinical implications for diagnosis and treatment.
Journal of dentistry (Shiraz, Iran)
Source →Diagnostic Approach for Cricoid Cartilage Tumors.
Lianou AD, et al
Cricoid cartilage tumors are uncommon lesions of the larynx, with chondroma and chondrosarcoma being the most frequently encountered types, yet distinguishing a benign growth from a low-grade malignancy remains difficult because imaging findings and clinical symptoms often overlap. A new case report published in the journal Maedica describes a middle-aged male patient with a tumor at the posterior cricoid cartilage who underwent a minimally invasive transcervical biopsy rather than the more morbid tracheostomy approach in order to obtain a definitive histopathological diagnosis. The diagnostic workup integrated ultrasound, computed tomography, magnetic resonance imaging, flexible endoscopy, and intraoperative nerve monitoring to guide the procedure safely and precisely. The transcervical approach successfully yielded diagnostic tissue while preserving the structural integrity of the cricoid cartilage and the patient's laryngeal function, thereby avoiding unnecessary surgical morbidity. This case demonstrates that transcervical biopsy is a viable and safe diagnostic option for selected patients with cricoid cartilage lesions, and it underscores the importance of individualized, multimodality preoperative planning in the management of these rare tumors.
Maedica
Source →Beyond cancer: CAR-T cells redefining liver disease therapy.
Yashaswini CN, et al
A new review published in JHEP Reports examines the expanding application of chimeric antigen receptor T-cell (CAR-T) therapy beyond its established role in cancer treatment, focusing on its emerging potential in liver disease. CAR-T cells are genetically engineered immune cells that can be programmed to target specific proteins, and researchers are now exploring whether this precision approach can address conditions such as liver fibrosis, autoimmune hepatitis, and other non-malignant hepatic disorders. The review synthesizes preclinical and early clinical evidence suggesting that CAR-T cells can selectively eliminate disease-driving cell populations in the liver without the broad immunosuppression associated with conventional therapies. These findings represent a significant conceptual shift, positioning CAR-T technology as a versatile platform that may one day offer curative or disease-modifying options for patients with chronic liver conditions who currently have limited treatment choices. Clinicians and researchers are encouraged to consider the unique challenges of delivering CAR-T therapy to the liver environment, including immune tolerance mechanisms and safety considerations that differ from oncology settings.
JHEP reports : innovation in hepatology
Source →Immune Network Construction and Prognostic Evaluation of Checkpoint Genes in Endometrial Cancer Using STRING, MCODE, and GEPIA2.
Ribeiro DA Costa RE, et al
Researchers conducted an in silico study to map the immune gene network in endometrial cancer (EC) and evaluate how checkpoint genes affect patient survival, using publicly available genomic datasets from TCGA and GTEx. By building a protein-protein interaction network with STRING and Cytoscape tools, they identified key immune hubs and functional gene clusters relevant to tumor immunity. The analysis revealed that combined overexpression of twelve immune genes — including CTLA4, PDCD1, TIGIT, CD8A, GZMB, and FOXP3 — was associated with improved overall survival, suggesting a coordinated anti-tumor immune response. While CD40 was found to be downregulated and LGALS9 upregulated in EC, neither alone significantly influenced survival outcomes. These findings highlight specific immune checkpoint gene signatures that could serve as prognostic biomarkers and help guide the development of personalized immunotherapy strategies for endometrial cancer patients. The authors emphasize that validation in independent patient cohorts and correlation with clinical treatment data are necessary before these insights can be applied in routine clinical practice.
Cancer diagnosis & prognosis
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