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Platinum chemotherapy ages the liver | Science
Platinum-based chemotherapy drugs induce somatic mutations and accelerate biological aging of the liver in children treated for cancer, according to a study published in Science. The findings reveal that cisplatin and related agents leave a lasting mutational footprint in hepatocytes, effectively making the organ biologically older than the patient's chronological age. The discovery has significan…
Long-Term Analysis of Patients With Ewing Sarcoma Included in the Euro-EWING99 Study
The Journal of Clinical Oncology has published a long-term follow-up analysis of patients with Ewing sarcoma enrolled in the Euro-EWING99 multinational cooperative trial, one of the largest prospective studies in this rare bone malignancy. Euro-EWING99 randomized treatment strategies including chemotherapy intensification and high-dose therapy with stem-cell rescue. Detailed survival outcomes and …