Small Intestine
Four Radical Bowel-Sparing Procedures for the Treatment of Small Bowel Tumors: A Retrospective Cohort Study From a Prospective Clinical Trial.
Ignjatovic D, et al
A new artery-based surgical framework comprising four bowel-sparing procedures for small bowel tumors achieves standardized D3-volume lymphadenectomy with a median lymph node harvest of 31 (median D3-lymph node harvest of 12) and zero 30- or 90-day mortality in a cohort of 86 patients. Using preoper…
Source →AGA Clinical Practice Update on Management of Ampullary Neoplasms: Expert Review.
Barakat M, et al
The American Gastroenterological Association has issued a Clinical Practice Update establishing best-practice guidance for the management of ampullary neoplasms, a rare cancer accounting for 0.6%–0.8% of gastrointestinal malignancies whose incidence in young adults has increased over the past 20 yea…
Source →Cold Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors: Current Evidence and Clinical Perspectives.
Mikuriya Y, et al
A new narrative review published in DEN Open establishes cold snare polypectomy (CSP) as the principal cold resection technique for superficial non-ampullary duodenal epithelial tumors (SNADETs) smaller than 10 mm that are optically diagnosed as low-grade adenomas using white-light imaging and narro…
Source →Carcinoma in adenoma of the minor duodenal papilla completely resected by endoscopic mucosal resection.
Ozawa E, et al
A case report published in the Clinical Journal of Gastroenterology demonstrates that endoscopic mucosal resection (EMR) can achieve histologically complete resection of intramucosal adenocarcinoma arising in adenoma of the minor duodenal papilla — a site previously managed almost exclusively by pan…
Source →Clinical practice guidelines for duodenal cancer 2025.
Yasuda S, et al
Japanese gastroenterologists have published a revised 2025 edition of clinical practice guidelines for duodenal cancer, updating the landmark 2021 edition to reflect four years of new evidence. The revised guidelines clarify indications for endoscopic submucosal dissection (ESD) by stratifying crite…
Source →Comparative Analysis of Characteristics and Outcomes of Patients with Early-Onset Versus Average-Onset Small Bowel Neuroendocrine Tumors.
Gao MT, et al
A large retrospective study of 3,713 patients found that early-onset small bowel neuroendocrine tumors (EO-SBNETs), affecting patients aged 30–49, are independently associated with significantly better survival compared to average-onset disease (hazard ratio 0.50, 95% CI: 0.41–0.60), with a median o…
Source →Small Bowel Cancer: Implications of Preoperative Work-Up on Surgical Strategy.
Kjæstad E, et al
A retrospective single-center study of 187 operations for suspected small bowel cancer found that preoperative diagnostic workup correctly identified the tumor entity in only 118 of 187 (63%) cases, with CT scanning showing critically poor sensitivity for peritoneal metastases at just 9% and for mes…
Source →Disseminated Angiosarcoma With Multifocal Small-Bowel Involvement Presenting as Suspected Small-Bowel Bleeding.
Tomita M, et al
A rare case of disseminated angiosarcoma with multifocal small-bowel involvement was identified in a man in his 60s who presented with recurrent melena and transfusion-dependent anemia, with autopsy confirming the greatest tumor burden around an abdominal aortic stent graft, suggesting a possible pe…
Source →Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial.
Kjæstad E, et al
A prospective clinical trial of 86 patients demonstrated that extended central (D3) lymphadenectomy in small bowel cancer is both feasible and safe, with D3 dissection successfully performed in 74 patients (86%), no 30-day mortality, and a low anastomotic leak rate of only 3%. Critically, mesenteric…
Source →The impact of intraoperative small intestine arrangement on postoperative intestinal function recovery in patients with laparoscopic colectomy: A single-center, double-blinded, randomized controlled trial.
Ma S, et al
A randomized controlled trial of 160 patients found that intraoperative small intestine arrangement significantly accelerated postoperative bowel function recovery after laparoscopic colectomy, reducing time to first gas discharge from 54.9 ± 21.8 hours in the control group to 45.2 ± 19.7 hours in t…
Source →Jejunal Mixed Adenoneuroendocrine Carcinoma (MANEC) With a Novel PTPRK-RSPO3 Fusion Initially Presenting as a Large Ovarian Mass: Diagnostic Challenges and Poor Prognosis.
Wang R, et al
Clinicians have reported the first documented case of jejunal mixed adenoneuroendocrine carcinoma (MANEC) harboring a novel PTPRK-RSPO3 gene fusion, which initially presented as a 16.1 cm right ovarian mass in a 51-year-old woman, leading to significant diagnostic delays. The jejunal tumor was only …
Source →Urine 5-HIAA and quality of life in neuroendocrine neoplasia. Is there an association?
Chaudhry R, et al
A retrospective cross-sectional study of 232 patients with neuroendocrine neoplasms (NEN) found that higher urinary 5-HIAA (u5HIAA) concentrations were significantly associated with lower anxiety scores (GAD-7, p=0.032) and fewer gastrointestinal symptoms on the GINET21 scale (p=0.024), suggesting t…
Source →Familial Juvenile Polyposis Syndrome: A Case Report of a Cosegregation of SMAD4 Germline Pathogenic Variant c.403C>T and Review of the Literature.
Martinez CA, et al
Researchers report the first documented case of a Brazilian family carrying the SMAD4 germline pathogenic variant c.403C>T, confirming its familial cosegregation across three generations affected by juvenile polyposis syndrome (JPS). An 18-year-old female presenting with rectal bleeding and chronic …
Source →Gender-based differences and associated clinical manifestations and symptom severity of celiac disease: a 10-year retrospective study in a tertiary care center in Lebanon.
Fayyad-Kazan H, et al
A 10-year retrospective study (2015–2024) screening 1,779 patients at a Lebanese tertiary care center identified 51 biopsy-confirmed celiac disease cases and found significant gender-based disparities, with female patients experiencing substantially higher rates of anemia, iron and vitamin D deficie…
Source →Subcentimeter Ileal Neuroendocrine Tumor Resection for Obscure Gastrointestinal Bleeding Followed by Pacemaker-Treated Sick Sinus Syndrome: A Case Report.
Llerena-Velastegui J, et al
A 72-year-old man presenting with obscure gastrointestinal bleeding was found to harbor a subcentimeter grade 1 small-intestinal neuroendocrine tumor measuring 0.8×0.6 cm that had already metastasized to 1 of 2 regional lymph nodes (pT3 pN1, Ki-67 index 2%), confirming that nodal spread can occur ev…
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