Stomach
TIP60-mediated acetylation of UHRF1 is associated with tumor cell-dependent M2-like macrophage phenotypes and aggressiveness in gastric cardia adenocarcinoma.
Wang B, et al
A new study identifies the TIP60/UHRF1 acetylation axis as a key driver of gastric cardia adenocarcinoma (GCA) progression, showing that TIP60 acetylates UHRF1 at four specific lysine residues — K644, K646, K648, and K650 — to simultaneously enhance tumor cell aggressiveness and promote polarization…
Source →Socioeconomic, biological, and behavioral determinants of gastric cancer incidence and mortality in Latin America and the Caribbean: a sex-stratified ecological study with projections to 2050.
Gonzalez-Lopez S, et al
Educational inequality is the most consistent determinant of gastric cancer burden in Latin America and the Caribbean, associated with higher mortality overall and with both incidence and mortality among women, in whom Human Development Index and Helicobacter pylori prevalence were also significant …
Source →Exploring the Molecular Mechanisms of Weifuchun in the Treatment of Chronic Atrophic Gastritis Based on Single-cell Sequencing and Machine Learning.
Chen H, et al
A study combining single-cell RNA sequencing and machine learning identified JUN and MMP12 as the key molecular targets through which Weifuchun (WFC), a classical traditional Chinese medicine compound, exerts its therapeutic effects against chronic atrophic gastritis (CAG) — a common precancerous le…
Source →Tailored Hybrid Laparoscopic-Endoscopic Surgery for Gastric Subepithelial Tumors: An Algorithm-Based Comparative Study with Long-Term Outcomes.
Mahawongkajit P, et al
A comparative algorithm-based study published in the Journal of Gastrointestinal Surgery demonstrates that a tailored hybrid laparoscopic-endoscopic approach can be systematically applied to resect gastric subepithelial tumors, with favorable long-term oncological and surgical outcomes. The study ev…
Source →PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype.
Wang Q, et al
Researchers have identified PRKX as a key molecular driver of immune evasion in gastric cancer, showing that it phosphorylates PD-L1 at threonine 285, recruits YWHAE, and prevents UBE2M-mediated ubiquitination and degradation, thereby stabilizing PD-L1 protein and suppressing CD8+ T-cell cytotoxicit…
Source →To express or not to express HLA-G: tissue undifferentiation is the answer in gastrointestinal tumors.
Juarez I, et al
A new review integrating original cohort data finds that HLA-G protein — a potent immune-suppressive molecule — is aberrantly expressed in 41.2% of gastric and 36.4% of colorectal adenocarcinomas, while being completely absent from matched healthy mucosa. Critically, HLA-G positivity was strongly li…
Source →Bcl-xL Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt/β-Catenin Activation and PPARγ Suppression.
Oya Y, et al
A new preclinical and translational study demonstrates that Bcl-xL, the anti-apoptotic protein encoded by BCL2L1, promotes gastric tumorigenesis through two apoptosis-independent mechanisms: amplifying Wnt/β-catenin signaling and suppressing the transcription factors HNF4α and PPARγ. Using Mist1-Cre…
Source →Cancer-associated fibroblast-enriched TAGLN orchestrates HGF/c-MET-dependent transcriptional reprogramming in gastric cancer.
Li Q, et al
Researchers have identified a key signaling cascade — CAF-TAGLN/HGF/c-MET/DDX5/CAV1 — by which cancer-associated fibroblasts (CAFs) drive tumor growth, malignant phenotypes, and peritoneal metastasis in gastric cancer (GC). TAGLN, enriched in CAFs, was found to boost HGF production via NF-κB activat…
Source →Navigating Antibody-Drug Conjugate Sequencing in Gastric Cancer: Cross-Resistance Biology, Target Switching, and Decision-Making Frameworks for the Post-Progression Landscape.
Wu Y
A new three-pillar decision-making framework for sequencing antibody-drug conjugates (ADCs) in advanced gastric cancer has been proposed, integrating cross-resistance risk stratification, real-time target landscape reassessment via dynamic re-biopsy and circulating tumor DNA (ctDNA), and shared pati…
Source →Extracellular vesicles in gastric cancer: biological functions, clinical applications, and engineering strategies.
Shi X, et al
A new systematic review published in Medical Oncology highlights the multifaceted roles of extracellular vesicles (EVs) in gastric cancer — one of the leading malignancies of the digestive system with particularly high burden in developing countries where late-stage diagnosis is common. The authors …
Source →Decoupling Ecological and Pathogenic Roles: Helicobacter pylori as a Gastric Hegemon Maintaining Order or Amplifying Dysbiotic Chaos.
Ma ZS, et al
A reanalysis of 756 gastric 16S rRNA gene profiles reveals that Helicobacter pylori acts as a context-dependent ecosystem modifier — consistently reducing microbiome divergence when present alone, yet amplifying disease-associated dysbiosis across multiple precancerous stages of the Correa cascade. …
Source →Gastric amphicrine carcinoma in the stomach: an unexpected presentation of MUTYH-associated polyposis.
Lee S, et al
Researchers report the first known case of gastric amphicrine carcinoma — an exceedingly rare tumor exhibiting simultaneous glandular and neuroendocrine differentiation within the same neoplastic cells — arising in a patient with MUTYH-associated polyposis (MAP), a hereditary autosomal recessive syn…
Source →Explainable Deep Learning of Transcriptomes Prioritizes Candidate Biomarkers With Preferential Performance in Gastric Cardia Cancer Cohorts.
Xu J, et al
An explainable deep learning classifier trained on public transcriptome data achieved a near-perfect cross-validated AUC of 1.00 (both ROC and precision-recall) for distinguishing gastric cardia tumors from normal tissue, and demonstrated preferentially stronger external performance in cardia-specif…
Source →Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis: A Real-World Propensity Score-Matched Study From the Autoimmune gastRitis Italian netwOrk Study grOup.
Massironi S, et al
A large real-world propensity score-matched study of 153,687 patients with autoimmune gastritis (AIG) found that proton pump inhibitor (PPI) use was associated with a 49% higher risk of developing gastric neuroendocrine neoplasms (gNENs), with occurrence rates of 0.89% in PPI users versus 0.60% in n…
Source →Ru-N coordination hydrogen-bonded organic frameworks with enhanced peroxidase-like activity for colorimetric determination of gastric cancer-related salivary D-amino acids.
Liang H, et al
Researchers developed a ruthenium-functionalized hydrogen-bonded organic framework nanozyme (Ru-HOFs) with enhanced peroxidase-like activity, enabling a cascade colorimetric platform for the non-invasive detection of gastric cancer-related D-amino acids in human saliva. Coupled with D-amino acid oxi…
Source →