Oesophagus
Development of a biomarker-guided chemotherapy response model using combined CEA and CA19-9 profiles in esophageal cancer: A real-world pharmacotherapeutic study.
Can O, et al
A retrospective real-world cohort study of 38 patients with histologically confirmed esophageal adenocarcinoma found that simultaneous elevation of both baseline CEA and CA19-9 was associated with the poorest overall survival, yielding a multivariable hazard ratio of 2.22. Patients were classified i…
Source →First-line systemic therapy for advanced or metastatic esophageal squamous cell carcinoma: clinical implications for treatment selection after KEYNOTE-590, CheckMate 648, and RATIONALE-306.
Sagawa T, et al
A comprehensive review of three landmark clinical trials — KEYNOTE-590, CheckMate 648, and RATIONALE-306 — establishes that PD-1 checkpoint inhibitors combined with chemotherapy have fundamentally reshaped first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC). KEY…
Source →Spatial mapping of cardiac dose-survival associations in oesophageal radiotherapy.
Marchant T, et al
A study of 452 patients treated with curative-intent radiotherapy for oesophageal cancer identified a spatially localized cardiac region where higher radiation dose was significantly associated with worse 12-month survival, with a maximum Cardiac Avoidance Area (CAA) dose threshold of 43.5 Gy produc…
Source →Dedicated Endoscopy for Barrett's Oesophagus With Higher Dysplasia Yield May Reduce Seattle Protocol Biopsies: Results From UK Multicentre Study.
Gamakaranage C, et al
A UK multicentre retrospective study of 2,013 Barrett's oesophagus surveillance procedures across 6 NHS hospitals found that dedicated endoscopy services achieved a dysplasia detection rate of 6.9%, more than double the 2.8% rate seen in conventional services (p < 0.001). The dedicated service also …
Source →Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells.
He J, et al
Researchers have discovered that zinc finger protein 600 (ZNF600) is a critical regulator of natural killer (NK) cell anti-tumor activity in esophageal cancer, with its expression found to be markedly reduced in exhausted EC-associated NK cells. Silencing ZNF600 in vitro caused significant downregul…
Source →A natural history model of oesophageal adenocarcinoma to inform power calculations for the BEST4 screening trial.
Landy R, et al
A new semi-Markov natural history model predicts that the BEST4 randomised controlled trial will have greater than 90% statistical power to detect a reduction in incidence of stage II+ or fatal oesophageal adenocarcinoma by 5.5 years of follow-up, and a reduction in OAC mortality by 7.5 years, under…
Source →Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer.
Derwa YH, et al
A new review published in The FEBS Journal demonstrates that the progression of Barrett's oesophagus to oesophageal adenocarcinoma requires not only the accumulation of genomic instability following TP53 loss, but also a permissive tumour microenvironment shaped by altered immune and stromal interac…
Source →Regulation of oestrogen signalling by the receptor tyrosine kinase cKIT stabilises the Barrett's Oesophagus pre-malignant state.
Suen KM, et al
A new study reveals that the receptor tyrosine kinase cKIT, expressed in Barrett's Oesophagus (BO) tissue but not in normal or cancerous oesophageal tissue, plays a key protective role in keeping the pre-malignant condition stable and preventing progression to oesophageal adenocarcinoma (OAC). Altho…
Source →Adeno- And Squamous Cell Carcinoma of the Esophagus and the Esophagogastric Junction: Long-Term Incidence Trends in Saarland (Germany), 1986-2024.
Stang A, et al
A long-term population-based analysis of esophageal cancer in Saarland, Germany, covering nearly four decades from 1986 to 2024, documents diverging incidence trends between the two main histological subtypes — adenocarcinoma and squamous cell carcinoma — of the esophagus and esophagogastric junctio…
Source →A systematic review on the clinical implementation of 4D particle therapy.
Visser S, et al
A comprehensive systematic review of 4D particle therapy has confirmed that intrafractional motion remains a major source of uncertainty across the entire treatment workflow for thoracic and abdominal cancers, while also demonstrating that motion-related challenges can be effectively managed using a…
Source →Longitudinal computed tomography body composition changes in patients receiving curative radiotherapy for non-small cell lung cancer.
Zhang Y, et al
A new study of 231 non-small cell lung cancer (NSCLC) patients finds that the rate of skeletal muscle loss and changes in left ventricular myocardial mass during routine follow-up CT scans powerfully predict overall survival after curative radiotherapy, with skeletal muscle loss faster than 0.4% per…
Source →Peri-oesophageal metastases of pulmonary adenocarcinoma presenting as dysphagia in a dog.
Beattie JM, et al
A rare case of canine dysphagia caused by peri-oesophageal metastases from a primary pulmonary adenocarcinoma has been documented in a twelve-year-old Border Collie, highlighting an atypical presentation of a cancer type that accounts for approximately one percent of all canine cancers. The dog pres…
Source →Association Between the Dietary Inflammatory Index (DII) and Head and Neck Cancer Incidence-A Narrative Review.
Katarzyna S
A narrative review published in Nutrients highlights a significant association between higher Dietary Inflammatory Index (DII) scores and increased risk of head and neck squamous cell carcinoma (HNSCC), a cancer group accounting for approximately 4.7% of all human cancers and predicted to become the…
Source →Postoperative management after oesophagectomy: An evidence-based approach.
Apostoloska M, et al
A comprehensive evidence-based review highlights that anastomotic leak and conduit ischaemia — driven by the limited blood supply from the right gastroepiploic artery — are the most serious and potentially fatal complications following oesophagectomy, a complex cancer surgery requiring multiple inci…
Source →Epigenetic biomarkers and the progression of Barrett's oesophagus to oesophageal adenocarcinoma: a systematic review protocol.
Johnston DN, et al
Researchers have registered a systematic review protocol (PROSPERO CRD42024509643) to evaluate whether epigenetic biomarkers — including DNA methylation, histone modifications, and non-coding RNAs — can predict which patients with Barrett's oesophagus (BO) will progress to high-grade dysplasia or oe…
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