Larynx
Therapeutic device as a facilitating resource for esophageal voice acquisition.
Rossi VC, et al
A novel catheter-based esophageal stimulation device enabled 60% (9 of 15) of total laryngectomized patients who had previously failed conventional speech-language therapy to develop functional esophageal voice for communication, while the remaining 40% (6 of 15) achieved esophageal sound production…
Source →Vestibular schwannoma surgery with cochlear implantation under continuous monitoring using the auditory nerve testing system: Three cases with distinct clinical scenarios.
Hosoya M, et al
A study of three patients demonstrates that the Auditory Nerve Test System (ANTS) can reliably provide continuous intraoperative monitoring of acoustic nerve preservation during simultaneous vestibular schwannoma resection and cochlear implantation, with all three patients achieving successful heari…
Source →Diagnostic accuracy of miRNA in detection of upper aerodigestive tract malignancies: a protocol for systematic review.
Tandon A, et al
Researchers have registered a systematic review protocol to rigorously evaluate how accurately microRNAs (miRNAs) can detect cancers of the upper aerodigestive tract — including the oral cavity, pharynx, and larynx — using minimally invasive biological fluid samples. Although individual studies have…
Source →Radiomics as a spatial context for treatment decision-making in head and neck cancer.
Kono T, et al
A narrative review published in the British Journal of Cancer argues that radiomics should not aim to outperform established tissue biomarkers in head and neck squamous cell carcinoma (HNSCC), but instead to contextualize them by capturing tumor spatial heterogeneity that a single biopsy cannot reli…
Source →Laryngeal Alveolar Rhabdomyosarcoma: An Exceedingly Rare Entity.
Hashim MM, et al
Researchers report only the fourth documented case of alveolar rhabdomyosarcoma (ARMS) of the larynx, an exceedingly rare malignancy, in a 54-year-old female who presented with progressive dyspnea, dysphonia, dysphagia, and otalgia. Imaging revealed a 2.8 × 2.3 × 1.9 cm fluorodeoxyglucose-avid supra…
Source →Application of statistical process control for quality assurance in radiotherapy planning of nasopharyngeal carcinoma.
Chen B, et al
A study of 200 nasopharyngeal carcinoma patients demonstrated that applying statistical process control (SPC) to radiotherapy planning significantly reduced radiation doses to the larynx and parotid glands while maintaining adequate target volume coverage. Researchers divided 100 patients into a bas…
Source →Laryngeal NUT Carcinoma With BRD4::NUTM1 Fusion: A 4-Year Clinical Course Highlighting the Limitations of Current Multimodal Therapy.
Kanno M, et al
A 30-year-old man with laryngeal NUT carcinoma driven by a BRD4::NUTM1 fusion was initially misdiagnosed as poorly differentiated squamous cell carcinoma, with the correct diagnosis established only after disease recurrence — illustrating the well-known diagnostic pitfall of this rare malignancy. Ov…
Source →Interpretable graph-conditioned CNNs for dose-volume histogram prediction in radiotherapy.
Zhu X, et al
A novel deep learning framework combining a three-dimensional convolutional neural network (CNN) with a graph neural network (GNN) directly predicts dose-volume histograms (DVHs) for multiple organs-at-risk in radiotherapy planning, cutting the mean dose prediction error for the brain stem from 1.24…
Source →A framework for delivering real-time, instrument-relative navigation in transoral robotic surgery.
Romero JO, et al
A real-time surgical navigation system dramatically improved targeting accuracy during transoral robotic surgery (TORS) for head and neck cancer, reducing target localization error by 5.44 mm (95% CI, 4.02–6.86 mm; p = 2.00e-11) and angular error by 8.47 degrees (95% CI, 6.21–10.72 degrees; p = 5.17…
Source →Diagnostic criteria and clinical outcomes of chronic nasopharyngitis treated with nasopharyngeal abrasive therapy: A multicenter prospective study.
Kumai T, et al
A multicenter prospective study of 175 patients found that nasopharyngeal abrasive therapy (EAT) significantly reduced symptoms of chronic nasopharyngitis, with median VAS scores for chief complaints falling from 90 at baseline to 60 after one month and to 25 after two months of weekly treatment wit…
Source →Analysis of mid-to-long term changes of tracheal volume after tracheal reconstruction.
Tazaki A, et al
A retrospective study of ten patients at Saitama Cancer Center found that neither soft tissue nor rigid tracheal reconstruction led to airway stenosis over a mid-to-long-term follow-up period spanning surgeries performed between April 2010 and March 2023. Five patients with 20–40% tracheal cartilage…
Source →Age-stratified clinical interpretation of AWGS2025 sarcopenia criteria in head and neck cancer treated with definitive chemoradiotherapy: Comparison with AWGS2019.
Kitoh R, et al
In a retrospective study of 97 head and neck cancer patients undergoing definitive chemoradiotherapy, the updated AWGS2025 sarcopenia criteria demonstrated substantial agreement with AWGS2019 in older adults aged ≥65 years (n=55), with sarcopenia prevalence of 20.0% versus 23.6% and a kappa coeffici…
Source →MRI-Guided Reduced-Volume RT for Early-Stage Glottic Cancer: A Prospective Phase 1 Trial with Quantification of Laryngeal Motion.
Leeman JE, et al
A prospective phase 1 trial has demonstrated that MRI-guided radiotherapy (MRgRT) targeting only the gross tumor volume — rather than the entire larynx — is feasible and safe for early-stage glottic cancer, with no acute or late grade 3+ toxicities observed across all enrolled patients. The trial ev…
Source →Failed Awake Flexible Intubation Followed by Early Surgical Tracheostomy in Advanced Laryngeal Cancer: A Case Report.
Kim B, et al
When standard awake flexible bronchoscopic intubation failed in a 69-year-old man with an obstructive T4a transglottic laryngeal carcinoma, an emergency surgical tracheostomy performed under local anesthesia by an on-standby otolaryngologist successfully secured the airway without perioperative comp…
Source →Oncological and functional outcomes of frontolateral vertical partial laryngectomy in selected patients with cT3N0 glottic carcinoma.
Yagi K, et al
Frontolateral vertical partial laryngectomy (FLVPL) achieved a laryngeal preservation rate of 87.5% with 3-year overall survival of 92.3% and disease-specific survival of 100% in 16 carefully selected patients with cT3N0 glottic carcinoma lacking vocal cord fixation or thyroid cartilage invasion. In…
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