Pharynx (naso-, oro-, hypopharynx)
Comparative Effectiveness of Induction Chemotherapy Regimens in Pediatric and Adolescent Locally Advanced Nasopharyngeal Carcinoma: A Retrospective IPTW Analysis.
Xie R, et al
In a retrospective study of 493 pediatric and adolescent patients (aged ≤ 21 years) with locally advanced nasopharyngeal carcinoma, non-taxane-plus-platinum induction chemotherapy regimens — including TPF/C, PF, and GP — were associated with significantly superior distant metastasis-free survival co…
Source →Circulating tumor HPV DNA reappearance as an early indicator of recurrence after radiotherapy-based treatment for HPV-associated oropharyngeal cancer: analysis of more than 2000 assessments in 232 patients.
Jabłońska IA, et al
A prospective study of 232 patients with HPV-positive oropharyngeal squamous cell carcinoma or carcinoma of unknown primary demonstrated that serial blood-based ctHPV DNA monitoring via quantitative PCR detects disease recurrence with 90.3% sensitivity and 97.9% specificity, and preceded clinical co…
Source →Clinicopathologic features and molecular characterization of oropharyngeal carcinomas harboring low-risk human papillomavirus.
Kmeid M, et al
A case series of 4 oropharyngeal carcinomas (OC) harboring transcriptionally active low-risk human papillomavirus (LR-HPV) has been described, expanding the known spectrum of HPV-associated lesions in the oropharynx. The tumors occurred in 3 men and 1 woman with a mean age of 67.8 years; all showed …
Source →Multi-Sequence Fusion MRI Deep Learning Models for Discrimination of Recurrent Nasopharyngeal Carcinoma and Osteoradionecrosis.
Gong W, et al
A dual-branch 3D-ResNet-50 deep learning model combining two MRI sequences achieved an AUC of 0.86 and accuracy of 84% — with sensitivity of 91%, specificity of 72%, and an F1 score of 0.87 — in distinguishing recurrent nasopharyngeal carcinoma (rNPC) from osteoradionecrosis (ORN) after radiotherapy…
Source →Pretreatment MRI-defined necrotic nodal phenotypes identify distant metastasis risk heterogeneity in N3 nasopharyngeal carcinoma.
Wang Y, et al
Pretreatment MRI-defined necrotic nodal phenotypes — encompassing severe radiologic extranodal extension, higher necrotic nodal burden, and multi-area necrosis — significantly stratify distant metastasis risk within N3 nasopharyngeal carcinoma, with N3b patients showing markedly inferior outcomes co…
Source →A Self-Adjuvant Photothermal Carbon Dot-Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis.
Ji R, et al
Researchers have engineered a biomimetic nanovaccine, CDC/Toy@CCM, consisting of toyocamycin-loaded, redox-responsive carbon dot clusters coated with homologous cancer cell membranes, that simultaneously treats and prevents nasopharyngeal carcinoma (NPC) by integrating photothermal therapy, chemothe…
Source →Efficacy and Toxicity of Triweekly Versus Weekly Cisplatin in Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma.
Cheng H, et al
A retrospective study of 205 patients with nasopharyngeal carcinoma (NPC) found that triweekly cisplatin (100 mg/m² every 3 weeks) and weekly cisplatin (40 mg/m²), both given concurrently with radiotherapy followed by adjuvant chemotherapy, produced equivalent long-term survival outcomes, with a 10-…
Source →Disparities and burden of illness among hospitalized cancer patients with opioid dependence.
Faruqui MM, et al
A national inpatient database study of 351,780 hospitalized cancer patients across three cohorts — renal cell carcinoma (RCC; n=88,105), prostate cancer (PC; n=209,410), and cancers of the lip, oral cavity, and pharynx (CLOP; n=54,265) — found that opioid dependence (OD) was consistently associated …
Source →Chemoradiotherapy versus transoral laser microsurgery for early T-stage (cT1-T2) hypopharyngeal cancer: A prospective randomized pilot study.
Ye CN, et al
A prospective randomized pilot study of 17 patients with early T-stage (cT1–T2) hypopharyngeal squamous cell carcinoma found that definitive radiotherapy with or without concurrent chemotherapy (RT/CCRT) achieved a significantly higher 1-year functional laryngeal preservation rate than transoral las…
Source →Diagnostic accuracy of miRNA in detection of upper aerodigestive tract malignancies: a protocol for systematic review.
Tandon A, et al
Researchers have registered a systematic review protocol to rigorously evaluate how accurately microRNAs (miRNAs) can detect cancers of the upper aerodigestive tract — including the oral cavity, pharynx, and larynx — using minimally invasive biological fluid samples. Although individual studies have…
Source →A framework for delivering real-time, instrument-relative navigation in transoral robotic surgery.
Romero JO, et al
A real-time surgical navigation system dramatically improved targeting accuracy during transoral robotic surgery (TORS) for head and neck cancer, reducing target localization error by 5.44 mm (95% CI, 4.02–6.86 mm; p = 2.00e-11) and angular error by 8.47 degrees (95% CI, 6.21–10.72 degrees; p = 5.17…
Source →HPV-associated Oropharyngeal Squamous Cell Carcinoma: An Imaging Framework for AJCC Version 9 TNM Staging.
Rai P, et al
Radiologists now have a structured, staging-focused imaging framework for evaluating HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) under the AJCC/UICC version 9 TNM staging system, which introduces unequivocal imaging-detected extranodal extension (iENE) into clinical nodal staging an…
Source →Local therapy to recurrent/metastatic foci augments the benefit of immune checkpoint inhibitors in nasopharyngeal carcinoma.
Chen X, et al
Adding local therapy to immune checkpoint inhibitors (LOCI) significantly improved progression-free survival (PFS) in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC), with a median PFS of 30.53 months versus 16.77 months for immunotherapy alone (hazard ratio 0.524; 95% CI 0.3…
Source →HPV circulating tumor DNA as a potential prognostic and predictive biomarker in head and neck squamous cell carcinoma: a systematic review.
Filippini DM, et al
A systematic review of 60 studies encompassing 8,234 patients has confirmed that HPV circulating tumor DNA (HPVctDNA) is a highly accurate diagnostic and prognostic biomarker in HPV-related head and neck squamous cell carcinoma (HNSCC), achieving a median sensitivity of 91.1% and a median specificit…
Source →Pediatric lingual ectopic thyroid: two contrasting cases and a narrative literature review.
Shi Z, et al
A two-case report published in Frontiers in Pediatrics demonstrates that failure to consider lingual ectopic thyroid before surgical excision of a tongue-base mass in a 2-year-11-month-old girl led to inadvertent removal of her only functional thyroid tissue, resulting in overt hypothyroidism requir…
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