Salivary Glands
Sclerosing Polycystic Adenoma Masquerading as Malignancy on Fine Needle Aspiration Cytology.
Jayakumar P, et al
A case report published in Diagnostic Cytopathology demonstrates that sclerosing polycystic adenoma (SPA), a rare benign salivary gland neoplasm, can so convincingly mimic malignancy on fine needle aspiration cytology that a 29-year-old male patient received a pre-operative diagnosis of malignant ne…
Source →Synchronous bilateral parapharyngeal Warthin tumours without demonstrable parotid continuity: a case report and narrative literature review.
Soviš M, et al
A 59-year-old man undergoing staging for tongue squamous cell carcinoma was found incidentally to harbour synchronous bilateral prestyloid parapharyngeal space Warthin tumours — a rare presentation in which both lesions showed no demonstrable radiological or intraoperative continuity with either par…
Source →Robot-assisted brachytherapy targeting the stylomastoid foramen for parotid adenoid cystic carcinoma with facial nerve involvement: a retrospective study.
Li Z, et al
A retrospective study of 23 patients with parotid adenoid cystic carcinoma involving the facial nerve found that robot-assisted iodine-125 brachytherapy targeting the stylomastoid foramen achieved a mean seed placement error of just 1.46 ± 0.85 mm with intraoperative blood loss of only 2–3 mL, demon…
Source →Diagnostic accuracy of core needle biopsy versus fine-needle aspiration cytology in salivary gland malignancies: A systematic review and metaanalysis.
Ji J, et al
A systematic review and meta-analysis of 3,902 procedures found that ultrasound-guided core needle biopsy (CNB) achieves a pooled sensitivity of 90.5% for detecting salivary gland malignancies, substantially higher than fine-needle aspiration cytology (FNAC) at 60.1%, while both methods showed simil…
Source →Segmentation-guided peritumoral radiomics and machine learning for ultrasound-based classification of salivary gland tumors.
Chen H, et al
A segmentation-guided machine learning pipeline combining YOLOv8 automated tumor segmentation with a Support Vector Classifier achieved area-under-the-curve scores of 0.8117 and 0.7951 in an independent testing cohort (n = 121) and an internal validation cohort (n = 51), respectively, for distinguis…
Source →Molecular characterization of salivary cancers: Patterns of genomic alterations and potential for impact on therapeutic choices.
Kamali-Sarvestani M, et al
Next-generation sequencing of tumours from 58 patients with advanced salivary gland cancers identified targetable genomic alterations in 37% of cases, substantially expanding the potential for personalised treatment in this rare disease. PIK3CA mutations were the most frequent finding across all his…
Source →Diagnostic performance of radiomic features from FS-T2WI for parotid tumor classification: A comparison of deep learning and machine learning models.
Mao X, et al
A deep learning model called TabResNet achieved the highest diagnostic accuracy for distinguishing benign from malignant parotid tumors on MRI, reaching an area under the ROC curve (AUC) of 0.8913 — outperforming the best conventional machine learning model, Random Forest (AUC = 0.8641). The study a…
Source →Antibody-Based Proximity Labeling Reveals Bait-Proximal Proteomes in Paraffin-Embedded and Snap-Frozen Tissue Samples.
de Krijger I, et al
Researchers have successfully adapted the antibody-based ProtA-Turbo proximity labeling system for use in both formalin-fixed paraffin-embedded (FFPE) and snap-frozen tissue specimens, enabling the direct mapping of protein-protein interactions within primary patient material. The method demonstrate…
Source →Diagnosis and Management of Upper Lip Sialolithiasis Identified via Conventional Dental Radiography: A Case Report.
Matsubara M, et al
A standard dental radiograph successfully identified a 0.5-mm radio-opaque sialolith in the upper lip minor salivary gland of a 73-year-old male patient, enabling an accurate preoperative diagnosis of a condition that is rarely detected before surgery. Sialolithiasis of the minor salivary glands is …
Source →Therapeutic targeting of E2F inhibits stemness of salivary gland mucoepidermoid carcinoma.
Vanini JV, et al
Researchers found that pharmacologic inhibition of the E2F transcription factor pathway using the compound HLM006474 significantly reduced the fraction of cancer stem cells (ALDHhighCD44high) in mucoepidermoid carcinoma (MEC), both in laboratory cell lines and in tumor xenograft mouse models. The st…
Source →Systemic amyloidosis diagnosed by labial salivary gland biopsy.
Guan FL, et al
A minimally invasive labial salivary gland (LSG) biopsy successfully confirmed a diagnosis of systemic amyloid light-chain (AL) amyloidosis in a patient in his 60s who presented with acute decompensating heart failure, demonstrating amyloid deposits via salmon-pink Congo red staining under light mic…
Source →Changes in the minor salivary glands and ductal carcinoma resulting from induction of oral carcinogenesis.
Maia CR, et al
A rat model study using 4NQO-induced oral carcinogenesis (45 experimental rats, 11 controls, observed from week 8 to week 30) found that degeneration of the secretory portion was the most prevalent histopathological change in both lingual and palatal minor salivary glands (MiSGs), reducing salivatio…
Source →Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate Complicated by Surgical Site Infection: A Case Report.
Kavuyiro AM, et al
A 29-year-old male patient underwent successful excision of a pleomorphic adenoma — the most common benign salivary gland tumor — arising from the minor salivary glands of the hard palate, an exceptionally rare location, followed by an uncommon postoperative complication: surgical site infection of …
Source →Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases.
Choi I, et al
A comprehensive review published in the Journal of Periodontal Research establishes saliva as a powerful, non-invasive liquid biopsy platform capable of detecting a broad spectrum of oral and systemic diseases, including periodontal inflammation, oral and head and neck cancers, non-oral cancers, aut…
Source →Risk-adapted neck dissection in salivary gland carcinoma: integrating occult nodal metastasis patterns with contemporary guidelines.
Johnson F, et al
A comprehensive review of salivary gland carcinomas (SGCs) finds that a one-stage, risk-adapted neck dissection strategy — tailored to tumor biology, histological grade, and diagnostic imaging — improves oncological outcomes and minimizes surgical complications. The incidence of occult nodal metasta…
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