Lip & Oral Cavity
An Atlas of Specificity Protein 1 in Oral Cancer: Networks, Therapeutics, and Priorities: A Scoping Review and scRNA-seq Analysis.
Choi S, et al
A scoping review of 38 studies found that Specificity Protein 1 (Sp1), a zinc-finger transcription factor, is consistently overexpressed in oral squamous cell carcinoma (OSCC) and associated with advanced clinical stage, lymph node metastasis, and poor prognosis, although direct human-tissue evidenc…
Source →Global Bibliometric Analysis of Post-Translational Modifications in Oral Squamous Cell Carcinoma.
Yang Y, et al
A global bibliometric analysis of 647 publications on post-translational modifications (PTMs) in oral squamous cell carcinoma (OSCC) reveals a sustained upward trend in research output, with China leading at 355 publications (46.16%), followed by Japan with 129 (16.78%) and the United States with 98…
Source →AI-Assisted Three-Class Oral Histopathology: A Reader Study.
Cheng S, et al
A three-class deep learning model (VGG16-BR) trained on 25,576 histopathology patches achieved a test-set accuracy of 0.9065, macro-F1 of 0.9086, and macro-AUC of 0.9628 in distinguishing normal tissue, oral leukoplakia, and oral squamous cell carcinoma, with an OSCC-to-Normal misclassification rate…
Source →Oral Fungal Infection Impacts Epithelial Innate Immunity to Promote Local and Distal Squamous Cell Carcinoma Progression.
Li X, et al
A study published in Cancer Research demonstrates that aggressive head and neck squamous cell carcinomas (HNSCCs) harbor an elevated burden of the environmental fungus Cladosporium cladosporioides, which establishes an immunosuppressive circuit driven by tumor-derived acidic metabolites — uric acid …
Source →KAT2B epigenetically activates GSTZ1 via H3K9ac to suppress proliferation and stemness and enhance ferroptosis in oral squamous cell carcinoma.
Sha T, et al
Researchers have identified the KAT2B–GSTZ1 molecular axis as a novel tumor-suppressive mechanism in oral squamous cell carcinoma (OSCC), showing that KAT2B epigenetically activates the GSTZ1 gene through histone H3 lysine 9 acetylation (H3K9ac) at its promoter, with GSTZ1 upregulated at log2FC = 1.…
Source →Druggable tumor-nerve-immune circuits in cancer pain: model systems, human translatability and therapeutic paradoxes.
Hu Y, et al
A critical narrative review published in Pharmacological Research reframes cancer pain as an active biological output of tumor-nerve-immune circuits rather than a passive consequence of tissue damage, identifying druggable nodes including NGF-TrkA, SLIT2-ROBO1, CGRP-CALCRL/RAMP1, and CSF1R-dependent…
Source →Long-term cancer trends among male Taiwanese farmers: an age-period-cohort analysis (2000-2023).
Francis LM, et al
A nationwide cohort study of 2,426,531 male Taiwanese agricultural workers aged 15–84, covering 2000–2023, found that overall cancer incidence among male farmers was higher than in the general male population and increased steadily across the 24-year study period. Lip and lung cancers showed signifi…
Source →Disparities and burden of illness among hospitalized cancer patients with opioid dependence.
Faruqui MM, et al
A national inpatient database study of 351,780 hospitalized cancer patients across three cohorts — renal cell carcinoma (RCC; n=88,105), prostate cancer (PC; n=209,410), and cancers of the lip, oral cavity, and pharynx (CLOP; n=54,265) — found that opioid dependence (OD) was consistently associated …
Source →Trends in Incidence and Mortality of Oral Cancer in Sri Lanka 2005-2022: A Population-Based Temporal Analysis.
Soysa NS, et al
A population-based study of Sri Lanka's Cancer Registry found that lip and oral cavity cancer (LOCC) incidence nearly tripled among males between 2005 and 2022, with the age-standardised incidence rate rising from 9.8 to 26.1 per 100,000, and doubling among females (from 2.9 to 5.7 per 100,000), acr…
Source →Spatiotemporal co-occurrence patterns and related risk factors of esophageal and lip and oral cavity cancers among older adults across 203 countries and territories: a machine learning-driven systematic analysis.
Zheng M, et al
A machine learning-driven global analysis of Global Burden of Disease 2021 data across 203 countries and territories found that esophageal cancer and lip and oral cavity cancer (LOC) share two key population-level risk factors among adults aged 55 and older — high alcohol use (esophageal RR=1.32, 95…
Source →Diagnostic accuracy of miRNA in detection of upper aerodigestive tract malignancies: a protocol for systematic review.
Tandon A, et al
Researchers have registered a systematic review protocol to rigorously evaluate how accurately microRNAs (miRNAs) can detect cancers of the upper aerodigestive tract — including the oral cavity, pharynx, and larynx — using minimally invasive biological fluid samples. Although individual studies have…
Source →The Impact of Advanced Age on Functional Recovery Following Glossectomy.
Chen J, et al
A retrospective study of 206 patients found that older adults (over 70) undergoing glossectomy for oral cavity cancer experience initial delays in functional recovery compared to younger patients, but long-term outcomes are largely comparable across age groups. Patients over 70 showed significantly …
Source →Burden of Lip, Oral Cavity, and Pharyngeal Cancers in China: Estimated in 2022 and Projections to 2050.
Ding C, et al
A comprehensive analysis using GLOBOCAN data estimates that 116,142 new lip, oral cavity, and pharyngeal (LOCP) cancer cases occurred in China in 2022, with nasopharyngeal cancer accounting for 43.9% of cases and lip and oral cavity cancer for 32.0%, both exhibiting a pronounced male predominance. P…
Source →Sclareol Inhibit Cell Growth and Induces Apoptosis via Activation of p53/p21 Signaling Pathways in Human Oral Squamous Cell Carcinoma Cells.
Nallu A, et al
Sclareol, a natural diterpene compound tested at concentrations of 5–50 µM, potently inhibited cell growth and induced apoptosis in human oral squamous cell carcinoma KB cells while demonstrating lower toxicity in normal Vero cells compared to the reference drug cisplatin. The compound triggered rea…
Source →A Novel Metric to Guide Cancer Priorities in Pakistan.
Aslam A, et al
A new metric called the delta Mortality-to-Incidence Ratio (dMIR) has been proposed to prioritize cancer control efforts in Pakistan, identifying stomach cancer (dMIR = 0.60), Kaposi sarcoma (dMIR = 0.58), and oral cavity cancer (dMIR = 0.49) as the cancers with the largest preventable outcome gaps …
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