Testis
[Large-cell calcifying Sertoli cell tumor of the testis in children: a clinicopathological analysis of four cases].
Wu BY, et al
A clinicopathological analysis of four pediatric cases of large-cell calcifying Sertoli cell tumor (LCCSCT) of the testis provides detailed characterization of this rare testicular sex cord-stromal neoplasm in children. LCCSCT is distinguished by large eosinophilic cells arranged in cords or nests w…
Source →Contemporary Trends in Primary Retroperitoneal Lymph Node Dissection in Nonseminomatous Germ Cell Tumors.
Lee NJ, et al
A large population-based study using the SEER database (2007–2022) found that the use of primary retroperitoneal lymph node dissection (RPLND) declined dramatically in marker-negative nonseminomatous germ cell tumors (NSGCTs) of the testis across all disease stages: in stage I, utilization dropped f…
Source →Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.
Kim B, et al
Researchers report a rare case of testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements in a 66-year-old immunocompetent man who presented with a 5 cm left testicular mass. Fluorescence in situ hybridization detected the IGH::M…
Source →Molecular analysis of testicular germ cell tumor in a male patient with 45,X/46,XY mosaicism: case report with review of literature.
Sano S, et al
In a landmark first, researchers performed molecular genetic analysis of a testicular germ cell tumor (TGCT) in a patient with 45,X/46,XY mosaicism, uncovering a heterozygous pathogenic KIT mutation (c.2446G>T, p.(Asp816Tyr)) and copy number gains across nearly all chromosomes — including 12p — find…
Source →Antibody-Based Proximity Labeling Reveals Bait-Proximal Proteomes in Paraffin-Embedded and Snap-Frozen Tissue Samples.
de Krijger I, et al
Researchers have successfully adapted the antibody-based ProtA-Turbo proximity labeling system for use in both formalin-fixed paraffin-embedded (FFPE) and snap-frozen tissue specimens, enabling the direct mapping of protein-protein interactions within primary patient material. The method demonstrate…
Source →PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin-proteasome system.
Wang X, et al
Researchers have identified PRAME as a key driver of invasion and metastasis in salivary adenoid cystic carcinoma (SACC), showing that it promotes tumour spread by binding to the Cullin2 ubiquitin ligase complex to accelerate degradation of the retinoic acid receptor RARα, while simultaneously upreg…
Source →Association Between Kita-Kyushu Lung Cancer Antigen-1 Positivity and Pathological High-grade Lung Adenocarcinoma.
Kondo Y, et al
In a study of 110 patients who underwent curative resection for lung adenocarcinoma, KK-LC-1 positivity (found in 35% of patients) was significantly associated with pathological high-grade tumor features — including larger invasive tumor size, advanced pathological stage, lymphatic invasion, vascula…
Source →Artificial intelligence-assisted design of MAGE-A4 ×CD16 T-cell receptor-like natural killer cell engagers.
Liu Y, et al
Using artificial intelligence-assisted computational structural prioritization combined with yeast-display screening, researchers engineered a novel natural killer cell engager (NKCE) targeting MAGE-A4, a cancer-testis antigen highly expressed in multiple malignancies but restricted in normal tissue…
Source →Postchemotherapy Germ Cell Tumor Phenotypes.
Fichtner A, et al
Pathologists managing testicular germ cell tumor patients must recognize a distinct spectrum of chemotherapy-induced histopathologic phenotypes — including growing teratoma syndrome, somatic-type malignancies, sarcomatoid yolk-sac tumors, vasculogenic mesenchymal lesions, and trophoblastic tumors — …
Source →USP35-mediated NRF2 deubiquitination attenuates experimental cryptorchidism-induced testicular damage and H2O2-induced apoptosis and oxidative stress in spermatogonia.
Liu X, et al
A new study identifies the USP35-NRF2 molecular axis as a critical protective mechanism against oxidative injury in spermatogonia, positioning USP35 as a promising therapeutic target for cryptorchidism-induced testicular damage and associated risks of male infertility and testicular cancer. Using a …
Source →LncRNA THOR regulates spermatogenesis by interacting with and stabilizing Sycp3 protein in zebrafish.
Zhao J, et al
Researchers have shown for the first time that the long non-coding RNA THOR directly interacts with and stabilizes the meiotic protein Sycp3 to control spermatogenesis in zebrafish, with THOR knockout producing a 38.7% reduction in sperm count alongside reduced motility, ultrastructural sperm defect…
Source →Somatic Cells in the Anuran Testis.
Ogielska M, et al
A new integrative review establishes that vertebrate testes, including those of anurans (frogs and toads), are evolutionarily homologous organs sharing a common organizational plan, with the defining distinction that anamniotes such as anurans exhibit cystic spermatogenesis while amniotes rely on tu…
Source →Telehealth in Urologic Oncology: Temporal Trends and Patient Characteristics in the United States.
Weitzner AS, et al
Telehealth use in urologic oncology remained low overall — peaking at just 1.93% of visits in 2020 during the COVID-19 pandemic before declining to 1.06% by 2023 — out of 85,237 total telehealth claims representing only 0.25% of all GU oncology outpatient visits in a large U.S. national commercial i…
Source →Paratesticular epithelioid sarcoma in a pediatric patient.
Ashley TR, et al
Researchers report the first documented case of paratesticular epithelioid sarcoma in a pediatric patient—an adolescent male—representing an exceedingly rare and aggressive malignancy with poor prognosis. The patient underwent wide hemiscrotectomy with radical inguinal orchiectomy followed by adjuva…
Source →Adenocarcinoma of the Rete Testis With PI3K/AKT/mTOR Pathway Alteration and a Gene Expression Profile Resembling Papillary Renal Cell Carcinoma: A Case Report.
Sharma S, et al
A case report demonstrates that adenocarcinoma of the rete testis (ACRT) — an exceptionally rare gland-forming scrotal tumor with typically poor prognosis — harbors alterations in the PI3K/AKT/mTOR signaling pathway and displays a gene expression profile closely resembling that of papillary renal ce…
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