Prostate

C61WHO Vol. 8
Male Reproductive System
★ 8.0The Lancet
2026-08-06

Phase 3 PSMAddition: adding [177Lu]Lu-PSMA-617 to hormone therapy extends radiographic progression-free survival in PSMA-positive metastatic prostate cancer (HR 0.72)

In the phase 3 PSMAddition trial (1144 patients, 572 per arm), adding the radioligand [177Lu]Lu-PSMA-617 to androgen deprivation therapy plus an androgen-receptor pathway inhibitor prolonged radiographic progression-free survival: HR 0.72 (95% CI 0.58-0.90; p=0.0021), a 28% relative reduction in the…

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