Ovary & Fallopian Tube
Trigonelline reverses cisplatin resistance in ovarian cancer cells by modulating ferroptosis via the Nrf2/GPX4 pathway.
Li J, et al
Trigonelline, a natural plant alkaloid, reverses cisplatin (DDP) resistance in ovarian cancer by promoting ferroptosis — an iron-dependent form of programmed cell death — through suppression of the Nrf2/GPX4 signaling pathway. Using DDP-resistant ovarian cancer cell lines SKOV-3/DDP and A2780/DDP, r…
Source →Bacteria-Based Ammunition for Cascade-Amplified Chemoimmunotherapy of Ovarian Cancer.
Miao Z, et al
Researchers developed a dual-responsive bacterial-nanoparticle system called VNP@BD-Poly — combining attenuated Salmonella VNP20009 with a BSA-doxorubicin polymer complex — that targets the hypoxic, immunosuppressive tumor microenvironment of ovarian cancer and releases doxorubicin in a pH/GSH-respo…
Source →PARP16 is a Druggable Regulator of Ribosome MARylation and Protein Homeostasis in Ovarian Cancer Cells.
Challa S, et al
A new study establishes PARP16 as a pharmacologically tractable target in ovarian cancer, showing that the selective small-molecule inhibitor DB008 disrupts ribosomal mono(ADP-ribosyl)ation (MARylation), impairs protein homeostasis, and significantly inhibits tumor growth in OVCAR3 xenograft models.…
Source →Hope is linked with more favorable tumor molecular signatures in serous ovarian cancer.
Lutgendorf SK, et al
A new study of 74 women with serous ovarian cancer found that higher levels of hope — measured before surgery — were associated with significantly more favorable tumor gene expression profiles, including reduced epithelial-mesenchymal transition (EMT; p = 0.008), lower pro-inflammatory signaling via…
Source →Expert consensus on cytopathological examination of intraoperative peritoneal effusion or pelvic/peritoneal washing for gynecological neoplasms
A multidisciplinary expert panel has published a formal consensus on standardising the cytopathological examination of intraoperative peritoneal effusions and pelvic or peritoneal washings in patients with gynaecological neoplasms, including ovarian and fallopian tube cancers. The consensus addresse…
Source →The evolving role of open abdominal surgery in gynecological malignancies in the era of minimally invasive and precision oncology.
Acs M, et al
Open abdominal surgery remains indispensable in gynecological oncology and has not been superseded by minimally invasive techniques, with open radical abdominal hysterectomy internationally reaffirmed as the standard of care for cervical cancer. This narrative review, based on a PubMed literature se…
Source →Temporal trends in short-term mortality in more than 5000 patients with early-stage ovarian cancer in Denmark and Sweden.
Andresen IH, et al
A population-based registry study of more than 5,000 patients with early-stage epithelial ovarian cancer (FIGO stages I–II) in Denmark and Sweden found that the 1-year absolute all-cause mortality risk declined by 6% per year (95% CI: −12% to 0%) in Denmark over 2004–2019, while remaining stable in …
Source →Patient-derived organoids as predictor of clinical response in ovarian cancer: a systematic review.
Vegter M, et al
A systematic review of 12 studies published between 2019 and 2026 found that patient-derived organoids (PDOs) show strong promise as predictors of ovarian cancer treatment response, with the two prospective validation studies — the highest-quality evidence — reporting predictive accuracies of 89% an…
Source →Pseudomyxoma peritonei from independent primary ovarian and appendiceal tumors: a case report.
Koo J, et al
A rare case of pseudomyxoma peritonei (PMP) arising simultaneously from two independent primary tumors — an ovarian mucinous carcinoma and an appendiceal mucinous neoplasm — was identified and successfully treated in an 83-year-old woman, with immunohistochemistry confirming distinct tumor origins t…
Source →Non-anatomical liver resection using Kelly clamp-crush technique during interval cytoreduction.
Heda A, et al
A case report demonstrates that non-anatomical wedge liver resection using the Kelly clamp-crush technique is feasible and safe as part of interval cytoreductive surgery in advanced ovarian cancer with oligometastatic hepatic disease. Surgeons successfully removed a 2.5×2 cm intraparenchymal liver l…
Source →Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model.
Samad M, et al
A new study combining clinical data from 179 women with PCOS and 228 controls with a mouse model finds that reduced adiponectin alone does not exacerbate anxiety-like behaviour in the absence of hyperandrogenism, suggesting that elevated androgens — not low adiponectin — may be the key driver of men…
Source →Annual Report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2023 and Annual Treatment Report for 2018.
Kajiyama H, et al
Japan's national gynecologic oncology registry reveals that 8,061 patients began treatment for cervical cancer in 2023, with 5-year survival rates for those who started treatment in 2018 reaching 92.6% at Stage I, 75.7% at Stage II, 57.3% at Stage III, and 25.9% at Stage IV. The report also captured…
Source →Bias in Meta-Analytic Modeling of Surrogate Endpoints in Cancer Screening Trials.
Long JP, et al
A new methodological study reveals that uncertainty in trial-level estimates systematically biases meta-analytic models toward falsely optimistic conclusions about the quality of surrogate endpoints in cancer screening trials. Using simulation and theoretical analysis, the researchers showed that wh…
Source →Evaluation of metabolic, reproductive, and gut microbiota alterations in a comparative study of different preclinical models of polycystic ovary syndrome.
Khobragade NH, et al
A comparative preclinical study found that the dihydrotestosterone (DHT)-only rat model most closely replicates the full spectrum of polycystic ovary syndrome (PCOS), demonstrating more pronounced metabolic, hormonal, reproductive, and gut microbial alterations than models using DHEA or sodium valpr…
Source →Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma of the Ovary Presenting With a Ruptured Sister Mary Joseph Nodule: A Rare Case Report From Northern Tanzania.
Lugata J, et al
A 54-year-old postmenopausal woman in northern Tanzania was diagnosed with well-differentiated invasive squamous cell carcinoma arising from malignant transformation of a mature cystic teratoma of the ovary, presenting with a spontaneously ruptured Sister Mary Joseph nodule — an exceptionally rare c…
Source →