Uterine Corpus (Endometrium)
Clinical and ultrasound characteristics of uterine perivascular epithelioid cell tumors.
Ferla S, et al
A retrospective multicenter study of 13 patients with histologically confirmed uterine PEComas found that initial transvaginal ultrasound correctly suspected malignancy in only 4 cases (31%), revealing a critical gap in preoperative detection of these rare tumors. The tumors — 8 malignant and 5 beni…
Source →Sintilimab‑related cystitis/ureteritis in high‑grade endometrial stromal sarcoma: A case report and structured literature review.
Yang S, et al
A 44-year-old woman with high-grade endometrial stromal sarcoma developed severe sintilimab-induced cystitis and ureteritis after three cycles of sintilimab combined with nab-paclitaxel and carboplatin — a rare urological immune-related adverse event that resolved dramatically with methylprednisolon…
Source →Measurement of Treatment Adequacy Influences Racial Disparities Estimates in Endometrial Cancer Care.
Felix AS, et al
Black patients with endometrial cancer consistently received guideline-concordant treatment (GCT) at significantly lower odds than White patients across all three major U.S. databases examined, with adequacy-based odds ratios of 0.84 (95% CI 0.79–0.90) in SEER-17, 0.75 (95% CI 0.73–0.77) in the Nati…
Source →The evolving role of open abdominal surgery in gynecological malignancies in the era of minimally invasive and precision oncology.
Acs M, et al
Open abdominal surgery remains indispensable in gynecological oncology and has not been superseded by minimally invasive techniques, with open radical abdominal hysterectomy internationally reaffirmed as the standard of care for cervical cancer. This narrative review, based on a PubMed literature se…
Source →Laparoscopic Resection of Vaginal Cuff Recurrence Following Surgery for Endometrial Cancer.
Makinoda C, et al
Surgeons successfully performed laparoscopic resection of an isolated vaginal cuff recurrence in a 57-year-old woman who had previously undergone laparoscopic hysterectomy for grade 1 endometrioid carcinoma (FIGO stage IA), with histopathology confirming recurrent grade 3 endometrioid carcinoma with…
Source →Analysis of changes in the phenotypic profile and frequencies of peripheral blood myeloid-derived suppressor cells in patients with endometrial cancer before and after surgical treatment.
Estrada-Estrada E, et al
A new study published in Cellular Immunology demonstrates that patients with endometrial cancer have significantly elevated frequencies of monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC) myeloid-derived suppressor cells in peripheral blood compared to healthy donors, and that these levels decrea…
Source →PPP1R3C functions as a tumor suppressor in endometrial cancer through promotion of glycogen synthesis.
Seol HS, et al
Researchers have identified PPP1R3C as a novel tumor suppressor gene in endometrial cancer that operates by promoting glycogen synthesis, offering a new mechanistic understanding of how this malignancy develops. PPP1R3C expression was found to be strongly down-regulated in uterine corpus endometrial…
Source →Assessing Foundation Models for Computational Pathology in Endometrial Cancer.
et al
Benchmark of seven state-of-the-art computational-pathology foundation models on 3,293 endometrial cancer patients from randomized trials and clinical cohorts, across morphological, molecular and prognostic tasks. H-OPTIMUS-0, CONCH and VIRCHOW2 achieved the highest mean performance, but the best mo…
Source →Pelvic ALK-Positive Inflammatory Myofibroblastic Tumor Presenting 8 Years After Uterine Smooth Muscle Tumor of Uncertain Malignant Potential.
Singleton AR, et al
A 59-year-old woman with a prior uterine smooth muscle tumor of uncertain malignant potential developed a large infiltrative pelvic mass 8 years later, ultimately diagnosed as an ALK-positive inflammatory myofibroblastic tumor (IMT) — a rare mesenchymal neoplasm with intermediate malignant potential…
Source →Annual Report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2023 and Annual Treatment Report for 2018.
Kajiyama H, et al
Japan's national gynecologic oncology registry reveals that 8,061 patients began treatment for cervical cancer in 2023, with 5-year survival rates for those who started treatment in 2018 reaching 92.6% at Stage I, 75.7% at Stage II, 57.3% at Stage III, and 25.9% at Stage IV. The report also captured…
Source →Cancer statistics for Asian American, Native Hawaiian, and Pacific Islander people, 2026.
Wagle NS, et al
A new American Cancer Society report reveals that cancer incidence among Asian American and Native Hawaiian and Pacific Islander (NHPI) ethnic groups varies dramatically when data are disaggregated, ranging from 218.3 per 100,000 Kampuchean people to 474.5 per 100,000 Native Hawaiian people — 1.5 ti…
Source →"Fibrosarcoma-like" Tumors of the Gynecologic Tract Show Distinct Molecular Subgroups: Tyrosine Kinase Fusions and Recurrent ERBB2/3 Mutations.
Marshall EH, et al
A study of 17 rare fibrosarcoma-like tumors of the gynecologic tract has identified two distinct molecular subgroups: tyrosine kinase gene fusions, found in 9 tumors (including 6 with NTRK fusions and 3 with COL1A1::PDGFB), and oncogenic ERBB2/ERBB3 variants, found in 6 additional tumors, each subgr…
Source →Delineating SWI/SNF gene and subtype expression in cancer.
Canfjorden V, et al
A large-scale genomic study profiling all 29 SWI/SNF chromatin remodeling genes across 33 tumor types and approximately 11,000 samples from The Cancer Genome Atlas found that while SWI/SNF subtype expression is broadly similar across cancers, four genes—ACTL6B, DPF1, DPF3, and SMARCD3—show the great…
Source →Vaginal natural orifice transluminal endoscopic surgery versus conventional laparoscopy for sentinel lymph node mapping in early-stage endometrial cancer: a systematic review and meta-analysis.
Karadeniz O, et al
A systematic review and meta-analysis of four comparative cohort studies enrolling 349 patients (148 vNOTES, 201 laparoscopy) found that vaginal natural orifice transluminal endoscopic surgery (vNOTES) achieved a bilateral sentinel lymph node detection rate of 86.8%, compared with 88.3% for conventi…
Source →Enhanced recovery after surgery in minimally invasive hysterectomy for uterine cancer: identifying predictors of same-day discharge.
Zerdan MB, et al
Among 972 women undergoing minimally invasive hysterectomy for uterine cancer within a standardized enhanced recovery after surgery (ERAS) pathway, 633 patients (65%) achieved same-day discharge in this retrospective cohort study from a tertiary cancer center spanning January 2020 to December 2024. …
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