Uterine Cervix
Cervical leukoplakia in Ghana: Unveiling diagnostic challenges and informing low-resource screening strategies.
Effah K, et al
A retrospective study of 13,861 women screened for cervical cancer in Ghana between 2016 and 2024 found that cervical leukoplakia occurred in 0.9% of women, and critically, 93.3% of these cases showed no acetowhitening on Visual Inspection with Acetic Acid (VIA) or mobile colposcopy, meaning the mos…
Source →Premature mortality and years of potential productive life lost due to HPV-attributable cancers in Brazil and Mexico: 2011 Versus 2023.
Pungartnik PC, et al
A population-based study of HPV-attributable cancer mortality in Brazil and Mexico found a persistent and growing burden of premature death between 2011 and 2023, with total HPV-attributable deaths rising from 6,515 to 9,533 in Brazil (years of life lost +44.6%) and from 4,303 to 4,997 in Mexico (ye…
Source →Cytotoxic phenanthrene and racemosol derivatives from Bauhinia malabarica roots: network pharmacology and in silico mechanistic insights.
Sawatdirak N, et al
Racemosol, a natural compound isolated from the roots of the medicinal plant Bauhinia malabarica, demonstrated potent cytotoxic activity against HeLa cervical cancer cells with an IC50 of 4.51 μM and induced cell death via apoptosis in a dose-dependent manner. Researchers isolated ten compounds in t…
Source →Design, synthesis, and screening of novel thienopyrimidine derivatives as PI3K/HDAC dual inhibitors against cervical cancer cells.
Wang W, et al
Researchers designed and synthesized a novel series of thienopyrimidine-based compounds as dual PI3K/HDAC inhibitors for cervical cancer, with lead compound B7 demonstrating potent activity against PI3Kα (IC50 = 25.41 ± 5.23 nM), PI3Kδ (IC50 = 41.58 ± 4.54 nM), and HDAC6 (IC50 = 29.35 ± 3.41 nM), al…
Source →INITIAL EVALUATION OF CERVICAL CANCER: A LITERATURE REVIEW OF STAGING CONIZATION FOR ACCURATE RISK STRATIFICATION AND GUIDANCE OF PRIMARY TREATMENT IN EARLY-STAGE DISEASE - A REVIEW FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP.
Chlala W, et al
A narrative review from the French Cervical Cancer Guidelines Group concludes that diagnostic or staging conization provides superior histopathological information — including tumor size, depth of stromal invasion, margin status, and lymphovascular space invasion (LVSI) — compared to pelvic MRI alon…
Source →The evolving role of open abdominal surgery in gynecological malignancies in the era of minimally invasive and precision oncology.
Acs M, et al
Open abdominal surgery remains indispensable in gynecological oncology and has not been superseded by minimally invasive techniques, with open radical abdominal hysterectomy internationally reaffirmed as the standard of care for cervical cancer. This narrative review, based on a PubMed literature se…
Source →Developing personas and empathy maps to understand perceptions of HPV self-sampling in the Somali American Community.
Tolessa A, et al
A qualitative study of 44 Somali American women (aged 30–65) in Minnesota identified six distinct personas — ranging from the Unfamiliar Individual to the Proactive Screener — capturing the diverse barriers, attitudes, and behaviors that shape engagement with cervical cancer screening and HPV self-s…
Source →Annual Report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2023 and Annual Treatment Report for 2018.
Kajiyama H, et al
Japan's national gynecologic oncology registry reveals that 8,061 patients began treatment for cervical cancer in 2023, with 5-year survival rates for those who started treatment in 2018 reaching 92.6% at Stage I, 75.7% at Stage II, 57.3% at Stage III, and 25.9% at Stage IV. The report also captured…
Source →Real-World Outcomes of Weekly Paclitaxel-Carboplatin-Based Chemoradiotherapy Versus Cisplatin-Based Chemoradiotherapy for FIGO Stage IB2-IVA Cervical cancer: A Retrospective Observational Study.
Shimizu A, et al
A retrospective study of 54 patients with FIGO stage IB2-IVA cervical cancer found no statistically significant difference in overall survival between weekly paclitaxel-carboplatin-based (wTC) and cisplatin-based (CDDP) concurrent chemoradiotherapy, with 3-year OS rates of 76.4% and 75.4%, respectiv…
Source →Case report of an unusual cecal metastasis of a primary cervical squamous cell carcinoma.
Fang M, et al
A rare case of cervical squamous cell carcinoma with cecal metastasis — a complication occurring in fewer than 2% of cases — achieved complete remission following sequential systemic chemotherapy and concurrent chemoradiotherapy, highlighting that intestinal spread can occur even in early-stage dise…
Source →Long-term risk of cancer following cervical intraepithelial neoplasia: A significant study leveraging Taiwan's national health insurance research database.
Sun Y, et al
A large population-based study using Taiwan's National Health Insurance Research Database found that women with moderate-to-severe cervical intraepithelial neoplasia (CIN2+) face more than double the long-term risk of any cancer compared to women without dysplasia, with a competing hazard ratio of 2…
Source →Herpetic reactivation during radiotherapy treatment for gynaecological cancers-a retrospective observational study.
Tom DC, et al
A retrospective study of 391 gynaecologic cancer patients found that herpes virus (HSV/VZV) reactivation occurred in 5.6% of patients during radiotherapy, with all 22 reactivation cases confined exclusively to cervical carcinoma patients (7.6%; p = 0.018). Key risk factors included concurrent chemot…
Source →"Fibrosarcoma-like" Tumors of the Gynecologic Tract Show Distinct Molecular Subgroups: Tyrosine Kinase Fusions and Recurrent ERBB2/3 Mutations.
Marshall EH, et al
A study of 17 rare fibrosarcoma-like tumors of the gynecologic tract has identified two distinct molecular subgroups: tyrosine kinase gene fusions, found in 9 tumors (including 6 with NTRK fusions and 3 with COL1A1::PDGFB), and oncogenic ERBB2/ERBB3 variants, found in 6 additional tumors, each subgr…
Source →Synergistic U-bent geometry and bimetallic plasmonics for ultra-sensitive fibre-optic SPR biosensing of cervical cancer.
Singh SK, et al
Researchers have developed a highly sensitive U-bent fibre-optic biosensor (FOB) integrating bimetallic gold-silver (Au-Ag) nanocoatings that achieves a maximum sensitivity of approximately 34,050 nm RIU⁻¹ in the refractive index range of 1.42–1.43, with sustained sensitivity of approximately 22,000…
Source →mRNA vaccines targeting HPV E6/E7: a new frontier in cervical cancer immunotherapy
This is a review article (not a clinical trial, with no original results) covering work from 2020-2026 on therapeutic mRNA-lipid nanoparticle vaccines directed against the HPV oncoproteins E6 and E7 — proteins made by cells that have ALREADY undergone malignant change. That distinguishes them from t…
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