Sellar Region
Prognosis
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🔬 Histological Types
📚 Latest Research
Fetal Craniopharyngioma: A Rare Prenatal Diagnosis.
Reyl C, et al
Researchers report a prenatal diagnosis of adamantinomatous craniopharyngioma (ACP) detected at 30 weeks of gestation — one of fewer than 20 such cases ever documented in the medical literature. Routine third-trimester ultrasound revealed a midline suprasellar brain mass with mixed solid and cystic components and calcifications, subsequently confirmed by fetal MRI; after the parents opted for termination, fetopathological examination at 31 weeks confirmed the ACP diagnosis histologically. Notably, all reported fetal cases correspond exclusively to the adamantinomatous subtype and share consistent radiological and histological features, supporting the concept that the full morphological phenotype of ACP is already established during fetal life. This case highlights the importance of thorough prenatal imaging and fetopathological examination, and reminds clinicians that despite its benign classification, ACP carries serious risks for long-term visual, endocrine, and neurodevelopmental morbidity.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Source →Relationship between retinal nerve fibre thickness, suprasellar extension and post-operative visual outcome in pituitary macroadenoma.
Cheng TC, et al
A prospective study of 38 pituitary macroadenoma patients found that thicker pre-operative retinal nerve fibre layer (RNFL) significantly predicted better post-operative visual recovery, with each additional 10 µm of global RNFL thickness associated with a 0.13 improvement in logMAR visual acuity (β=-0.013, P<0.001) and a 0.83 dB improvement in visual field mean deviation (β=0.083, P=0.008). Surgery produced significant improvements in both best-corrected visual acuity (median logMAR from 0.301 to 0.176, P<0.001) and visual field mean deviation (from -10.04 to -3.91 dB, P<0.001), while patients with normal pre-operative RNFL achieved substantially better post-operative visual fields (median MD -2.35 dB) compared to those with thinned RNFL (median MD -6.63 dB, P=0.009). Critically, suprasellar extension of the tumour — rather than overall tumour volume — was the anatomical parameter most strongly correlated with RNFL thinning across all sectors, offering clinicians a practical imaging and OCT-based framework for predicting visual prognosis before surgery.
International journal of ophthalmology
Source →Third Ventricular Chordoid Glioma With TTF-1 Positivity: A Diagnostic and Therapeutic Challenge.
Shen Z, et al
A rare primary brain tumor called chordoid glioma of the third ventricle is frequently misdiagnosed because its imaging appearance is nonspecific, and this case report identifies TTF-1 immunoreactivity as the critical immunohistochemical marker needed for a definitive pathological diagnosis. The study underscores that this uncommon neoplasm presents a dual challenge: reaching the correct diagnosis and then selecting optimal therapy. The authors conclude that management must be individualized, carefully balancing the extent of surgical resection, adjuvant radiotherapy, and surveillance according to each patient's surgical risk profile and the tumor's recurrence potential.
Clinical case reports
Source →💊 Therapies
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🧪 Tumor markers
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