Orbit & Lacrimal Gland
Orbital Extranodal Marginal-Zone Lymphoma and Crystal-Storing Histiocytosis Related to a Longstanding Silicone Scleral Buckle.
Langley L, et al
A rare case of orbital extranodal marginal-zone lymphoma (EMZL) co-occurring with crystal-storing histiocytosis was found to be causally linked to the chronic presence of a silicone scleral buckle implant, suggesting that long-term foreign-body antigenic stimulation may drive mucosa-associated lymph…
Source →Orbital spindle cell neoplasm with neural differentiation: diagnostic challenges in the absence of molecular confirmation.
Asensio-Sánchez VM, et al
A case report describes an 82-year-old man with a history of treated rectal adenocarcinoma who presented with progressive orbital pain and right-sided proptosis, in whom orbital exenteration and histopathological examination revealed a high-grade infiltrative spindle cell neoplasm at the orbital ape…
Source →DOTATATE-PET in custom spheno-orbital implant design for meningiomas with orbital involvement: a case series.
Tennyson JM, et al
A study of 4 patients with hyperostosing spheno-orbital meningiomas demonstrated that integrating DOTATATE-PET molecular imaging into the design of custom polyetheretherketone (PEEK) patient-specific implants enabled single-implant reconstruction of combined skull and orbital defects, with visual ou…
Source →Aggressive, recurrent diffuse orbital Lipoblastomatosis - a rare and challenging encounter.
Tripathy D, et al
Researchers report a rare and aggressive case of diffuse orbital lipoblastomatosis in a young girl, a primitive embryonal adipose tissue tumor that recurred relentlessly despite radical surgical removal and adjuvant therapy. Lipoblastomatosis is an extremely uncommon tumor in the orbit, with only a …
Source →Composite Graft of Cavum Conchae for Eyelid Defect: A New Approach.
Zhao F, et al
A novel reconstructive technique using auricular composite tissue grafts successfully repaired periocular defects in all 10 patients who underwent malignant orbital tumor resection, with no postoperative complications or tumor recurrences observed over a follow-up period of 4 to 52 months. The patie…
Source →Comparison of Systemic and Mucosal Synchronous Immunization with Replicating Single-cycle Adenoviruses and SOSIP Protein HIV-1 Vaccines.
Nehete PN, et al
Intravaginal (IVAG) mucosal vaccination with a replicating single-cycle adenovirus (SC-Ad) HIV-1 vaccine protected 50% of immunized rhesus macaques against vaginal clade C SHIV challenge 1.5 years after the last vaccination, while animals vaccinated intranasally or intramuscularly were all infected …
Source →Head and Neck Rhabdomyosarcoma in Children: An Otolaryngological Perspective on Diagnostic and Therapeutic Approaches.
Wojno A, et al
A comprehensive review of head and neck rhabdomyosarcoma (HNRMS) in children highlights that approximately 30–40% of all rhabdomyosarcoma cases originate in the head and neck region, with orbital tumors identified as carrying the most favorable prognoses, while parameningeal lesions continue to pose…
Source →Clinical, CT, and MR Findings for the Pretreatment Diagnosis of Primary Epithelial Tumors of the Lacrimal Gland.
Chang Y, et al
A retrospective study of 18 patients with histologically confirmed primary epithelial tumors of the lacrimal gland found that MRI outperforms CT in sensitivity and accuracy for detecting orbital bone invasion in adenoid cystic carcinoma (ACC), while CT remains valuable for evaluating cortical bone c…
Source →Navigare necesse est: The transorbital route to intraparenchymal temporal lesions.
Agosti E, et al
A systematic review of 13 clinical studies encompassing 41 patients found that endoscopic transorbital approaches (ETOAs) offer a safe and effective minimally invasive route for removing intraparenchymal temporal brain lesions, achieving gross total resection in 73.0% of cases and subtotal or partia…
Source →Primary ocular-adnexal non-Hodgkin Lymphoma in a Peruvian cohort: An 18-year experience.
Luque-Benavides R, et al
In a retrospective 18-year study of 98 Peruvian patients with primary ocular-adnexal non-Hodgkin lymphoma (POANHL), 5-year overall survival reached 94.8% for indolent lymphomas but fell to 59.7% for aggressive forms, underscoring a stark prognostic divide in this rare malignancy. The orbit was the m…
Source →Harnessing light and ultrasonic vibration: efficient amphiphilic phthalocyanine-based sensitizers for combined sono-photodynamic therapy of breast cancer.
Çakmak H, et al
Amphiphilic zinc- and indium-based phthalocyanine sensitizers achieve singlet oxygen quantum yields of ΦΔ = 0.89–0.98 under combined sono-photodynamic therapy (SPDT) conditions, a striking improvement over ΦΔ = 0.39–0.49 measured with photodynamic therapy (PDT) alone, driven by ultrasonic cavitation…
Source →Isolated deep orbital haemangioma in an infant presenting to the emergency department with right-sided proptosis.
Bikou EM, et al
A 3-month-old infant presenting to the emergency department with a 2-week history of progressively worsening right-sided proptosis was diagnosed with an isolated deep orbital haemangioma, a finding that reinforces current evidence identifying orbital haemangiomas as the most prevalent primary orbita…
Source →Author Correction: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
Genovese G, et al
This notice is an author correction to a previously published Nature study investigating synthetic vulnerabilities — targeted therapeutic weaknesses — within mesenchymal cell subpopulations of pancreatic cancer, a disease notorious for its poor prognosis and treatment resistance. The original resear…
Source →Two cases of giant cell tumours of the orbit: one case of giant cell tumor associated with Paget's disease of bone and one case of tenosynovial giant cell tumor.
Hong R, et al
Researchers report two rare cases of giant cell tumors (GCT) involving the orbit, a site where only three prior cases of soft-tissue GCT have ever been documented in the scientific literature. One case involved a giant cell tumor associated with Paget's disease of the bone, while the second was a te…
Source →Sequential presentation of Wilms' tumor and orbital rhabdomyosarcoma in a child with mosaic variegated aneuploidy syndrome 3.
Vempuluru VS, et al
A 12-year-old girl who developed orbital embryonal rhabdomyosarcoma nine years after being treated for left Wilms' tumor was found — through whole-exome sequencing — to carry a likely pathogenic null variant in the TRIP13 gene (c.998_999delCT, p.Ser333Leufs*30), establishing a diagnosis of mosaic va…
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