Conjunctiva
Global incidence of ocular surface squamous neoplasia and histopathologic subtypes: A systematic review and meta-analysis.
Sriranganathan A, et al
A systematic review and meta-analysis of 24 studies encompassing 33,615 incident cases found that conjunctival squamous cell carcinoma (SCC) incidence is highest in Africa at 5.04 per 1,000,000 person-years (95% CI 2.72–9.34), compared to a global pooled estimate of 0.70 per 1,000,000 person-years (…
Source →Utility of ultrasound biomicroscopy in detecting invasive ocular surface squamous neoplasia.
Rehman O, et al
Ultrasound biomicroscopy (UBM) can predict invasive ocular surface squamous neoplasia (OSSN) with 73.3% accuracy, 71.4% sensitivity, and 100% specificity when compared against postoperative histopathological examination as the gold standard. This retrospective single-institution study included 15 pa…
Source →Benign and Malignant Conjunctival Lesions in Children.
Pe'er J, et al
A comprehensive review of conjunctival lesions in children confirms that the vast majority are benign, with conjunctival nevi being the most common type encountered in clinical practice. Rare malignant conjunctival tumors in the pediatric population tend to present at an older age and are typically …
Source →Genomic and Transcriptomic Analysis of Sinonasal Mucosal Melanoma and Conjunctival Melanoma.
Cui J, et al
A whole-exome and RNA sequencing study of 25 sinonasal mucosal melanomas (SNMM) and 9 conjunctival melanomas (CM) found that nearly all cases in both groups harbored alterations in the RTK-RAS signaling pathway, with RAS mutations significantly associated with shorter progression-free survival speci…
Source →Corrigendum to Interferon Alpha-2a as Treatment for Primary Acquired Melanosis With Atypia and for Primary Acquired Melanosis With Atypia Surrounding Conjunctival Melanoma. Am J Ophthalmol. 2026;285:318-323.
Vaisman D, et al
A corrigendum has been issued to a previously published study in the American Journal of Ophthalmology (2026;285:318-323) examining Interferon Alpha-2a as a treatment for primary acquired melanosis (PAM) with atypia, including cases surrounding conjunctival melanoma. The correction addresses an erro…
Source →Epidemiology of ocular surface squamous neoplasia and squamous papillomas in Hong Kong Chinese: A 10-year review.
Kam KW, et al
A 10-year retrospective study of 50 eyes in 48 Hong Kong Chinese patients revealed a stable annual incidence of ocular surface squamous neoplasia (OSSN) and squamous papilloma of 0.34 per 100,000 persons, with men more frequently affected and male sex alongside a history of pterygia or pinguecula id…
Source →Solitary fibrous tumour of the conjunctiva: a rare presentation.
Sreekumar SR, et al
A rare case of solitary fibrous tumour of the conjunctiva was successfully diagnosed and treated in a man in his early 50s who presented with a painless, slow-growing temporal bulbar mass over four months. Anterior segment optical coherence tomography (AS-OCT) characterised the subepithelial lesion …
Source →Locally Invasive Conjunctival Squamous Cell Carcinoma Refractory to Plaque Radiotherapy.
Dalvin LA, et al
A case report published in Cornea documents a 69-year-old man whose conjunctival squamous cell carcinoma (SCC) proved refractory to six cycles of topical 5-fluorouracil chemotherapy, repeated excisional biopsies, tectonic scleral patch grafting, and plaque radiotherapy, ultimately requiring orbital …
Source →Modelling targeted therapy efficacy in NRAS mutant conjunctival melanoma.
Välimäki E, et al
In a case study of immune checkpoint therapy-resistant metastatic conjunctival melanoma harboring NRAS, FBXW7, TERT, and TP53 mutations, ex vivo drug testing identified marked sensitivity to PARP, MEK, and RAS(ON) inhibitors as well as to the chemotherapies cisplatin and docetaxel. Following a molec…
Source →Conjunctival Squamous Cell Carcinoma Masquerading as Orbital Cellulitis in a Patient With Relapsed Mixed Phenotype Acute Leukemia.
Izadian Bidgoli A, et al
A case report demonstrates that conjunctival squamous cell carcinoma (SCC) can dangerously mimic orbital cellulitis in profoundly immunocompromised patients, causing critical diagnostic delays. A 40-year-old man with relapsed mixed phenotype acute leukemia (MPAL) presented with progressive unilatera…
Source →Cytokine Release Syndrome Induced by Combination Therapy With Nivolumab and Ipilimumab in Lower Palpebral Conjunctival Melanoma: A Case Report.
Suzuki K, et al
A case report in The Journal of Dermatology documents cytokine release syndrome (CRS) — a potentially life-threatening immune-related adverse event — arising in a woman in her 60s with advanced conjunctival melanoma after combination immunotherapy with nivolumab and ipilimumab, a complication consid…
Source →Conjunctival Extranodal NK/T-Cell Lymphoma, Nasal Type.
Ren T, et al
A publication in Ophthalmology describes conjunctival extranodal NK/T-cell lymphoma of nasal type, an exceptionally rare and aggressive haematological malignancy arising in the conjunctival tissue. This entity belongs to a subgroup of NK/T-cell lymphomas strongly associated with Epstein–Barr virus i…
Source →Conjunctival Foreign Body Granuloma With Hemosiderin Deposition Mimicking Malignant Melanoma.
Hwang M, et al
A pigmented conjunctival foreign body granuloma with extensive hemosiderin deposition can so closely mimic malignant melanoma — both clinically and on anterior segment optical coherence tomography (AS-OCT) — that it may prompt full oncological surgery, as occurred in this case report published in Co…
Source →Dissecting cellular heterogeneity across two ocular melanoma subtypes by single-cell RNA sequencing.
Gong Z, et al
A single-cell RNA sequencing study of 28 ocular melanoma samples — 14 uveal melanoma and 14 conjunctival melanoma — reveals that these two subtypes harbor fundamentally distinct tumor cell transcriptional programs and immune microenvironments, with conjunctival melanoma exhibiting significantly high…
Source →Topical Mitomycin C Chemotherapy After Surgical Resection of Conjunctival Amelanotic Melanoma in a Dog.
Ahn J, et al
A 15-year-old spayed female Shih Tzu with incompletely resected conjunctival amelanotic melanoma showed no clinically detectable local tumor recurrence during a 14-month postoperative follow-up period after adjuvant topical 0.04% mitomycin C (MMC) ophthalmic solution administered four times daily fo…
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