Kaposi Sarcoma
KSHV promotes leukocyte adhesion and transendothelial migration via induction of VCAM1.
Zhang Z, et al
Researchers have identified a novel mechanistic link in Kaposi's sarcoma (KS): KSHV-infected endothelial cells in latency constitutively express vascular cell adhesion molecule 1 (VCAM1), which drives leukocyte adhesion and transendothelial migration (TEM) — hallmark processes of KS tumor lesions — …
Source →HMGB1 as a convergent host factor in virus-induced carcinogenesis.
Kim SW, et al
A new conceptual review proposes that the chromatin-associated protein HMGB1 acts as a convergent host factor exploited by multiple human oncogenic viruses — most notably Kaposi's sarcoma-associated herpesvirus (KSHV) — to promote cancer progression through two sequential functional nodes. At the fi…
Source →The TRAF6-Akt axis is required for efficient lytic replication of KSHV.
Liu Z, et al
A new study demonstrates that TRAF6, long regarded solely as an antiviral defense protein, paradoxically promotes lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) by mediating K63-linked polyubiquitination and activation of the kinase Akt. CRISPR-mediated knockout or small-molecul…
Source →A Novel Metric to Guide Cancer Priorities in Pakistan.
Aslam A, et al
A new metric called the delta Mortality-to-Incidence Ratio (dMIR) has been proposed to prioritize cancer control efforts in Pakistan, identifying stomach cancer (dMIR = 0.60), Kaposi sarcoma (dMIR = 0.58), and oral cavity cancer (dMIR = 0.49) as the cancers with the largest preventable outcome gaps …
Source →HHV-8 Infection in Solid-Organ Transplant-Pathogenesis, Epidemiology, Clinical Manifestations and Management.
Chittrakarn S, et al
A comprehensive review of Human herpesvirus-8 (HHV-8) infection in solid-organ transplant recipients proposes a novel risk-stratified donor and recipient screening algorithm alongside a practical management framework for patients who test HHV-8 PCR-positive but remain asymptomatic, filling a critica…
Source →Oral Hobnail Hemangioma of the Maxillary Labial Mucosa: Clinicopathologic Findings of a Rare Case.
Dinç K, et al
Researchers report a rare case of oral hobnail hemangioma diagnosed in a 57-year-old edentulous woman who presented with discomfort from her dental prosthesis, in whom intraoral examination revealed a bluish-purple, smooth-surfaced, asymptomatic nodular lesion on the anterior maxillary labial mucosa…
Source →Matrix-dependent HHV-8 DNA detection in paired buffy coat and plasma from patients with hematological diseases in the Brazilian Amazon.
Mineiro LS, et al
A study of 350 patients with hematological diseases in the Western Brazilian Amazon found HHV-8 DNA in 19 individuals (5.43%; 95% CI: 3.50–8.32%), but strikingly, 18 of those 19 positive cases showed discordant results between buffy coat and plasma — nine were positive only in buffy coat, nine only …
Source →Cancer Prevalence and Associated Health Outcomes Among Adults With HIV in the United States: Medical Monitoring Project Data, 2019-2022 Cycle Years.
Koehler EE, et al
A nationally representative study of 14,798 U.S. adults living with HIV found that an estimated 66,641 persons with HIV (6.7%) had received a cancer diagnosis in the prior 24 months, with 54,863 (5.5%) diagnosed with a non-AIDS-defining cancer. Using Medical Monitoring Project data collected from Ju…
Source →Diagnostic concordance and delayed recognition: a case of atypical Kaposi sarcoma.
Cohn H, et al
A 47-year-old woman with Kaposi sarcoma (KS) experienced repeated diagnostic delays because her presentation — a chronic, unilateral, non-violaceous eruption of the left lower extremity — lacked the classic clinical and histopathologic features of the disease, with serial biopsies showing only derma…
Source →Human Herpesvirus 8 Causes a Wide Spectrum of Disease in Liver Transplant Recipients and May be Donor Derived: Case Series and Systematic Review of an Emerging Challenge.
Waller KM, et al
A systematic review and case series of 135 liver transplant recipients found that Human Herpesvirus 8 (HHV8) disease carries high mortality, with 59 of 135 patients dying (49 from HHV8-related causes), and visceral Kaposi sarcoma or non-KS disease associated with markedly worse survival (adjusted ha…
Source →Classic lymphangioma-like Kaposi sarcoma in an HIV-negative elderly patient.
Solanoy VT, et al
A rare histological variant of Kaposi sarcoma — the lymphangioma-like subtype — was diagnosed in an HIV-negative elderly patient, illustrating the diagnostic challenge posed by this exceptionally uncommon presentation of an already rare tumor. Classic Kaposi sarcoma typically affects elderly men of …
Source →Evolving understanding of Kaposi sarcoma and associated diseases in the ART era.
Labo N, et al
A comprehensive review published in The Lancet HIV details the evolving understanding of Kaposi sarcoma (KS) and related lymphoproliferative disorders caused by KS-associated herpesvirus (KSHV/HHV-8), underscoring that KS represents a substantial burden of disease in sub-Saharan Africa and among peo…
Source →In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma.
Fulgenzi CA, et al
A new study published in the British Journal of Cancer reveals that intra-tumoral HHV-8 gene expression is a key driver of tumour microenvironment (TME) composition in both HIV-associated and classic Kaposi's sarcoma (KS), with viral gene activity positively correlating with activated CD4, CD8, NK c…
Source →Pyogenic Granuloma of the Buccal Mucosa Mimicking an Atypical Vascular Tumor: A Case Report.
Jeong Y, et al
Immunohistochemistry—demonstrating diffuse CD31 and CD34 positivity, absent HHV-8, a low Ki-67 index, and no aberrant p53 expression—was decisive in reclassifying a diagnostically challenging 1.0 cm ulcerated buccal mucosal mass as pyogenic granuloma (PG) in a 69-year-old woman, after the initial pa…
Source →Demographic Characteristics, Clinical Features, and Treatment Patterns of Classic and AIDS-Related Kaposi Sarcoma: A Multicenter Real-World Study from Turkey.
Dişli AK, et al
A multicenter real-world study of 102 Kaposi sarcoma (KS) patients in Turkey found that classic KS patients survived significantly longer than those with AIDS-related KS, with a median overall survival of 66.9 months versus 22.67 months (p = 0.012). The study, conducted across five tertiary oncology…
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