Malignant Melanoma
Long-Term Outcomes Support Utilization of 23-GEP in Clinically Ambiguous Melanocytic Neoplasms.
Bal KS, et al
A real-world cohort study of 267 clinically ambiguous melanocytic lesions with a median 6-year follow-up found that the 23-gene expression profile (23-GEP) test successfully guided a definitive diagnosis in 89.5% of difficult-to-diagnose cases. Event rates (recurrence or metastasis) were 11.5% for l…
Source →[Analysis of therapeutic effects of proton and heavy ion radiotherapy on uveal melanoma].
Yue H, et al
A retrospective study of 69 patients with uveal melanoma treated at Fudan University between 2015 and 2025 found that both proton beam therapy (12 patients, 17.4%) and heavy ion radiotherapy (57 patients, 82.6%) produced statistically significant tumor regression: the largest basal tumor diameter de…
Source →Characteristics of plasma-activated water and its effect on apoptosis of malignant melanoma cells.
Chen M, et al
Plasma-activated water (PAW) generated by a helium atmospheric pressure plasma jet triggers mitochondrial apoptosis in malignant melanoma cells, with the longest irradiation treatment (PAW5, 5 minutes) producing the strongest cytotoxic effect. Researchers found that PAW treatment reduced B16 melanom…
Source →Histopathologic, Genomic, and Clinical Characteristics of Primary Cutaneous Melanocytic Tumors With Concomitant NRAS Q61 and IDH1 R132C Mutations.
Ebbelaar CF, et al
A new study of 16 primary cutaneous melanocytic tumors harboring both NRAS Q61 and IDH1 R132C mutations establishes that this molecular profile spans a spectrum from intermediate-grade melanocytoma to frank melanoma, with 7 cases classified as melanocytoma and 9 as melanoma. Melanomas were distingui…
Source →Molecular pathology in the diagnosis of cutaneous melanoma.
Luzar B, et al
A new review highlights that melanoma is not a single disease but rather nine distinct clinicopathological entities, each defined by unique genetic pathways, as recognized by the latest 5th edition of the World Health Organization (WHO) classification of melanocytic tumours. The classification incor…
Source →Ethanol-induced cellular metastable state sensitization for copper-based oxidative tumor therapy.
Liu Y, et al
A single intratumoral injection of Nano-CuEOP, a polyethylene glycol-stabilized nano-sized copper ethoxide nanoparticle, achieved efficient melanoma treatment and remodeled the tumor immune microenvironment in preclinical models. Upon uptake by melanoma cells, Nano-CuEOP releases ethanol and convert…
Source →Spinal intramedullary melanocytoma: systematic review & clinical management considerations.
Bättig L, et al
A systematic review of 35 patients with spinal intramedullary melanocytoma (SIM) — an exceptionally rare benign tumor of the spinal cord — found that although neurological status was stable or improved in 84.0% of cases at long-term follow-up, recurrence occurred in 43.3% of patients over a mean fol…
Source →Targeting MAPK Pathways in Skin, Thyroid, and Pancreatic Cancer: A Perspective on Synthetic Inhibitors and Natural Modulators.
Wasnik D, et al
A new review published in Advanced Biology examines how dysregulation of the MAPK signaling pathway drives melanoma, thyroid carcinoma, and pancreatic adenocarcinoma, concluding that combining transcriptomic evidence with molecular and pharmacological analyses could accelerate target prioritization …
Source →Translational Challenges and Opportunities in mRNA Cancer Vaccines
Seong Dong Jeong
This Cancer Discovery mini-review takes stock of therapeutic mRNA cancer vaccines. Personalised platforms (mRNA-4157, BNT122) are feasible and safe and produce durable immune activity, but scale poorly; off-the-shelf constructs (BNT111, BNT113) deploy faster and more broadly at the cost of precision…
Source →Intraoral desmoplastic melanoma requiring radical multidisciplinary resection and free flap reconstruction: case report and literature review.
Álvarez Vásquez FA, et al
A rare case of intraoral desmoplastic melanoma — an exceptionally uncommon site for an already rare melanoma variant — was successfully managed through radical en bloc resection and immediate anterolateral thigh free flap reconstruction in a male patient in his fourth decade of life. The tumor prese…
Source →[Masquerade syndrome-an interdisciplinary challenge].
Kress H, et al
A case report reveals that masquerade syndrome — a diagnostic concept in which neoplastic disease mimics ocular inflammation — caused a critical diagnostic delay in an 85-year-old patient whose intermediate uveitis and visual impairment were ultimately traced to axillary lymph node metastasis from a…
Source →Diverging melanoma mortality trends in Brazil: declining age-standardized rates despite persistent sex and regional inequalities, 2015-2024.
de Melo GS, et al
A nationwide ecological time-series study of melanoma mortality in Brazil from 2015 to 2024 found that age-standardized mortality rates declined from 0.84 to 0.74 per 100,000 inhabitants, representing an annual percent change of -1.29% (95% CI: -2.07 to -0.49), even as crude mortality rose slightly …
Source →Oral Mucosal Melanoma In Situ Manifesting as Multiple Gingival Macules Around a Dental Implant-Based Prosthesis: A Case Report.
Tosiou A, et al
A case report published in Case Reports in Dentistry describes a rare and diagnostically challenging presentation of oral mucosal melanoma in situ appearing as multiple black gingival macules around a dental implant-supported prosthesis in a 68-year-old Caucasian male, initially misdiagnosed as post…
Source →A thiosemicarbazone derivative as a potential multi-target inhibitor: Molecular docking, DFT, QTAIM, and NLO investigation of thione and thiol tautomers.
Benhalima N, et al
Researchers have identified the thione tautomer of a novel thiosemicarbazone derivative as a promising dual-inhibitor candidate for melanoma treatment, demonstrating strong binding affinity toward TYRP1 (−8.1 kcal/mol) and potent inhibitory activity against BRAF (Kᵢ = 0.214 μM) and MEK1 (Kᵢ = 0.497 …
Source →Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation.
Wu H, et al
A systematic review published in Frontiers in Oncology concludes that photoacoustic imaging (PAI) may extend vascular visualization beyond the optical scattering limit and enable label-free depiction of intratumoral vascular features in thicker intraocular lesions — a capability not reliably provide…
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