Pancreas
Australian Pancreatic Cyst Registry: protocol for a prospective national clinical quality registry of intraductal papillary mucinous neoplasms.
Poh AR, et al
Australia has launched the Australian Pancreatic Cyst Registry (APCR), a prospective, multicentre national clinical quality registry designed to enrol up to 10,000 individuals with intraductal papillary mucinous neoplasms (IPMNs) — common pancreatic precancer lesions with malignant potential — over …
Source →EPHA2 and WNT reciprocally regulate MAPK-dependent gene expression in a pancreatic cancer model.
Wadia SR, et al
A new study in JCI Insight reveals that the receptor tyrosine kinase EPHA2 suppresses EGFR and ERK activation in pancreatic cancer xenografts, and that loss of EPHA2 renders tumors more sensitive to both erlotinib and Wnt pathway inhibitors. Using phosphotyrosine-targeted mass spectrometry, research…
Source →An atypical case with recurrent episodes of pancreatitis: is eosinophilic pancreatitis a diagnosis or a mimic in the spectrum of IgG4-related diseases? A case-based review : Eosinophilic pancreatitis or IGG4-releated disease.
Okyar B, et al
A case report reveals that eosinophilic pancreatitis (EP) can closely mimic both pancreatic malignancy and IgG4-related disease (IgG4-RD), making careful clinicopathological correlation essential to avoid misdiagnosis. A 43-year-old man underwent distal pancreatectomy in 2016 for suspected cancer an…
Source →Synthetic long peptide and DNA personalized cancer vaccines induce robust neoantigen-specific T cell responses in pancreatic cancer
Two phase 1 trials (NCT03956056, NCT03122106) tested personalized neoantigen vaccines — synthetic long peptide and DNA — given after resection and adjuvant chemotherapy in pancreatic ductal adenocarcinoma. The vaccines were well tolerated, with no grade 3 or higher adverse events, and induced polycl…
Source →Intraoperative decision-making for pancreatic ductal adenocarcinoma with occult para-aortic lymph node metastasis: Proposal of a pathology-based weighted risk scoring system.
Shibamoto J, et al
A pathology-based weighted risk scoring system developed from six microscopic features of intraoperatively sampled para-aortic lymph nodes can objectively guide surgeons on whether to resect pancreatic ductal adenocarcinoma (PDAC) when occult nodal metastases are discovered during surgery. In a coho…
Source →A rare case of metastatic Merkel cell carcinoma presenting without a primary cutaneous lesion: A case report.
Luo N, et al
A 44-year-old male was diagnosed with metastatic Merkel cell carcinoma (MCC) presenting with no identifiable primary skin lesion, an uncommon and diagnostically challenging phenomenon known as occult-primary MCC. The diagnosis was confirmed through comprehensive immunohistochemical profiling, includ…
Source →Itaconate and its derivatives in human health and diseases.
Gu J, et al
A comprehensive review published in Signal Transduction and Targeted Therapy establishes the IRG1/ACOD1–itaconate axis as a central immunometabolic checkpoint that links the tricarboxylic acid cycle to immune signaling, coordinating inflammatory tone and redox balance across a broad spectrum of dise…
Source →Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines.
Van Veldhuisen CL, et al
A large prospective multicenter European study of 207 patients undergoing surgery for chronic pancreatitis found that adherence to current morphology-based guidelines (achieved in 66% of cases) was not associated with improved outcomes, with major morbidity rates of 12.9% in guideline-concordant ver…
Source →A Spleen-Preserving Approach Using Partial Splenectomy for Pancreatic Tail Lesions: A Video Case Report.
Daniel JB, et al
Surgeons successfully performed a robotic distal pancreatectomy combined with partial splenectomy to remove a 4-cm pseudopapillary neoplasm located at the splenic hilum in a 38-year-old woman, achieving clear surgical margins while preserving meaningful splenic function. The procedure, conducted usi…
Source →Targeting MAPK Pathways in Skin, Thyroid, and Pancreatic Cancer: A Perspective on Synthetic Inhibitors and Natural Modulators.
Wasnik D, et al
A new review published in Advanced Biology examines how dysregulation of the MAPK signaling pathway drives melanoma, thyroid carcinoma, and pancreatic adenocarcinoma, concluding that combining transcriptomic evidence with molecular and pharmacological analyses could accelerate target prioritization …
Source →Casein Kinase 1 Alpha 1 Is Over-expressed in Pancreatic Adenocarcinoma Tissues and Correlates With Shorter Patient Survival.
Yamashita S, et al
A new bioinformatics study reports that Casein Kinase 1 Alpha 1 (CSNK1A1), a serine/threonine protein kinase involved in Wnt signaling and p53 tumor suppressor pathways, is significantly overexpressed at both the mRNA and protein level in pancreatic adenocarcinoma (PAAD) tissue compared to normal pa…
Source →Micro-vascularized Multicellular Pancreatic Ductal Adenocarcinoma (PDAC) spheroid: A novel 3D PDAC Research Model.
Li H, et al
Researchers have developed a novel three-dimensional multicellular pancreatic ductal adenocarcinoma (PDAC) spheroid model using a porcine pancreas-derived decellularized extracellular matrix (dECM) hydrogel, demonstrating that cancer-associated fibroblasts (CAFs) and endothelial CD93 differentially …
Source →Normal Tissue Complication Probability Estimation for Metabolic Syndrome in Survivors of the Dutch National Wilms Tumor Cohort: A DCCSS-LATER Study.
Wens FS, et al
Survivors of Wilms tumor (WT) face nearly three times the risk of metabolic syndrome (MetS) compared to age- and sex-matched controls, with a prevalence of 18.8% versus 7.3% (OR 2.94; 95% CI 1.92–4.49). In this cross-sectional Dutch cohort study of 265 WT survivors (median age 33.9 years; median fol…
Source →Artificial Intelligence-Estimated Intrapancreatic Fat and Its Relationship to Familial and Germline Pancreatic Cancer Risk.
Konikoff T, et al
A deep-learning AI pipeline for whole-pancreas MRI analysis found no significant difference in intrapancreatic fat (IPF) between 85 high-risk individuals (HRIs) with a family history of pancreatic cancer or pathogenic germline variants and 170 age-, sex-, BMI-, and diabetes-matched controls (mean pr…
Source →Diagnosis, clinical assessment, and staging of hepatocellular carcinoma: a Brazilian multidisciplinary consensus.
Coimbra FJ, et al
A panel of 43 Brazilian experts from 10 medical specialties has published a multidisciplinary consensus establishing 18 evidence-based recommendations for the diagnosis, clinical assessment, and staging of hepatocellular carcinoma (HCC), coordinated by the Brazilian Society of Surgical Oncology alon…
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