Liver & Intrahepatic Bile Ducts
Ferroptosis, immune activation and MASH-related HCC.
Kuchay MS, et al
A new review published in Gut establishes a self-amplifying, bidirectional ferroptosis–immune axis in metabolic dysfunction-associated steatohepatitis (MASH) as a critical driver of hepatocellular carcinoma (HCC) development, anchored by a novel four-gene transcriptomic signature — FABP4, CAPG, QSOX…
Source →Ultrasound Molecular Imaging and Visualization of Immune Biomarkers: A New Paradigm for Tumor Immunotherapy Response Assessment.
Zhang Q, et al
A systematic review published in Ultrasound in Medicine & Biology establishes ultrasound molecular imaging (USMI) as a promising non-invasive tool for real-time visualization of immune biomarkers within the tumor immune microenvironment, with dedicated pre-clinical evidence across hepatocellular car…
Source →Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis.
Wang Z, et al
Researchers have demonstrated that pachymic acid, a natural compound, synergistically enhances the antitumor efficacy of lenvatinib — a first-line drug for hepatocellular carcinoma (HCC) — by targeting the PPARγ receptor to suppress aerobic glycolysis in cancer cells. In laboratory experiments, comb…
Source →Harnessing copper-iron crosstalk: A novel strategy to combat hepatocellular carcinoma.
Xie X, et al
A new review published in Medical Oncology proposes that simultaneously targeting cuproptosis and ferroptosis — two distinct metal-driven cell death pathways — represents a promising therapeutic strategy against hepatocellular carcinoma (HCC). Mitochondrial copper overload disrupts protein lipoylati…
Source →Interpretable prediction of macrotrabecular-massive HCC and recurrence-free survival by integrating MRI LI-RADS features with deep learning habitat radiomics.
Zhang M, et al
A multicenter study of 607 patients with early-stage hepatocellular carcinoma (HCC) demonstrated that a nomogram integrating MRI LI-RADS features, deep learning scores, and habitat radiomics can preoperatively identify the aggressive macrotrabecular-massive (MTM+) subtype with areas under the ROC cu…
Source →Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures.
Gillmeister A, et al
A new study finds that next generation sequencing (NGS) detects malignant biliary strictures with 65% sensitivity, outperforming standard histopathology at 52% sensitivity, while maintaining comparable high specificity of 96% versus 100%. When NGS was combined with histopathology, sensitivity for ma…
Source →Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis.
Dunn DP, et al
The PREMIUM study is a large multicenter randomized controlled trial sponsored by the U.S. Department of Veterans Affairs that aims to determine whether dynamic contrast-enhanced abbreviated MRI (aMRI) plus serum AFP reduces hepatocellular carcinoma (HCC)-related mortality more effectively than ultr…
Source →Inhibitory effects of c-MYC degrading rLON protease on intestinal polyps in PIRC rat, a familial adenomatous polyposis model.
Venkatachalam K, et al
A recombinant bacterial protease (rLONP) that degrades the cancer-driving protein c-MYC reduced total intestinal polyp burden by 60% or more in PIRC rats, a standard animal model of Familial Adenomatous Polyposis (FAP), after just 2 to 4 weeks of twice-daily oral treatment at 2.5 mg/kg (p<0.001). Ma…
Source →Long-term cancer trends among male Taiwanese farmers: an age-period-cohort analysis (2000-2023).
Francis LM, et al
A nationwide cohort study of 2,426,531 male Taiwanese agricultural workers aged 15–84, covering 2000–2023, found that overall cancer incidence among male farmers was higher than in the general male population and increased steadily across the 24-year study period. Lip and lung cancers showed signifi…
Source →Post-Transplant Hepatitis D Breakthrough Driven by Integrant-Derived HBsAg from an Extrahepatic HCC Metastasis.
Di Marco L, et al
Researchers have identified a rare and clinically significant mechanism by which hepatitis D virus (HDV) infection can re-emerge after liver transplantation: hepatitis B surface antigen (HBsAg) produced by integrated HBV DNA within an extrahepatic metastasis of hepatocellular carcinoma (HCC), not fr…
Source →Engineering extracellular vesicles for targeted siRNA delivery: Advances, therapeutic applications, and clinical translation.
Varshan GS, et al
A comprehensive review published in Nanomedicine identifies engineered extracellular vesicles (EVs) as a highly versatile and biologically inspired platform capable of overcoming the principal delivery barriers — including rapid enzymatic degradation, poor cellular uptake, inadequate endosomal escap…
Source →Circular RNAs and SIRT1 in post-transcriptional regulation and human disease.
Vakili O, et al
A comprehensive review establishes that circular RNAs (circRNAs) regulate SIRT1 — an NAD⁺-dependent deacetylase central to metabolic homeostasis, stress adaptation, inflammation, autophagy, and aging — through complex post-transcriptional and signaling networks whose biological consequences are high…
Source →A CECT-Based 2PI System as a Novel Noninvasive Prognostic Tool for Hepatocellular Carcinoma: A Dual-Validation Study.
Cui Y, et al
A machine learning-based 2PI (Pathology and Prognosis-Informed Imaging System) built on contrast-enhanced CT imaging successfully predicted postoperative recurrence risk in hepatocellular carcinoma (HCC), with the Random Survival Forest model achieving C-index values of 0.76 (95% CI: 0.72–0.80) in t…
Source →FAP-targeted gold nanocluster-mediated radioligand therapy in combination with TGF-βRI inhibition for tumor therapy.
Yang H, et al
Researchers developed a gold nanocluster-based radioligand therapy agent called GNFAPI that achieved complete tumor responses in multiple preclinical models by combining targeted radiotherapy with stromal disruption, representing a significant advance in treating cancers driven by cancer-associated …
Source →Digital pathology, image analysis, and artificial intelligence in liver disease.
McGenity C, et al
A comprehensive review published in The Lancet Digital Health concludes that digital pathology and artificial intelligence — including deep learning — are rapidly transforming the diagnosis and management of liver cancer and liver disease, with access in clinical practice steadily increasing alongsi…
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