Platinum chemotherapy ages the liver | Science

Platinum-based chemotherapy drugs induce somatic mutations and accelerate biological aging of the liver in children treated for cancer, according to a study published in Science. The findings reveal that cisplatin and related agents leave a lasting mutational footprint in hepatocytes, effectively making the organ biologically older than the patient’s chronological age. The discovery has significant implications for long-term survivorship care, as the growing population of childhood cancer survivors may face elevated risks of liver-related morbidity decades after treatment.