Shaping the future of early-onset colorectal cancer prevention

A comprehensive Roadmap published in Nature Reviews Cancer addresses the global rise of early-onset colorectal cancer by mapping current knowledge gaps in modifiable and non-modifiable risk factors. The authors propose an integrative conceptual model that bridges molecular epidemiology, exposomics, and microbiome research to accelerate risk-factor discovery. The paper calls for transdisciplinary collaboration and meaningful patient engagement as essential components of reversing the rising incidence trend among younger adults.