Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer

Tang et al. constructed a cell-type-resolved prognostic atlas for pancreatic cancer by integrating single-nucleus RNA transcriptomes with long-term survival data from 152 patients. The study moves beyond bulk-level gene-expression analyses to pinpoint which specific cell populations within the tumor microenvironment drive differences in patient outcomes. This framework links intra-tumoral heterogeneity at single-cell resolution to clinical prognosis, providing a foundation for more precise biomarker development and risk stratification in pancreatic ductal adenocarcinoma.