Origins and consequences of oncogenic 3D chromatin remodelling

A new review in Nature Reviews Cancer synthesizes evidence that remodelling of 3D chromatin architecture in cancer cells functions both as a driver and a product of genetic and epigenetic alterations. Franceschini and colleagues detail how oncogenic mutations reorganize topologically associating domains, enhancer–promoter contacts, and compartmentalization, creating feedback loops that sustain malignant gene expression programs. The authors highlight emerging opportunities to exploit aberrant 3D chromatin conformations as diagnostic biomarkers and therapeutic targets.