Renal Pelvis & Ureter
Prognosis
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📚 Latest Research
A Novel Technique of Traction Pre-Bladder Suturing in Single-Position Robot-Assisted Nephroureterectomy: Simplifying the Management of the Intramural Ureter.
Xu J, et al
A novel four-step traction pre-bladder suturing technique for robot-assisted laparoscopic nephroureterectomy (RALNU) proved feasible and safe in all 10 consecutive patients with early-stage upper tract urothelial carcinoma (UTUC) treated between October 2022 and August 2023. The procedure achieved a mean operative time of 145 minutes — with 38 minutes dedicated to managing the intramural ureteral segment — and a mean blood loss of just 35 mL, with no intraoperative conversions or major complications. Pathological analysis confirmed complete (R0) resection of low-grade noninvasive carcinoma in every patient, and two metachronous bladder recurrences were observed over a median 12-month follow-up period. The technique, which combines mucosal tenting, a purse-string containment suture, en bloc mucosal resection, and reinforced double-layer bladder closure, offers a promising approach to minimise urine spillage and ensure secure bladder reconstruction during RALNU.
The international journal of medical robotics + computer assisted surgery : MRCAS
Source →Urothelial carcinoma of the renal pelvis and ureter with shadow cell morphology: report of a case
Chen SM, et al
A case report published in the Chinese Journal of Pathology describes an unusual presentation of urothelial carcinoma of the renal pelvis and ureter exhibiting shadow cell morphology, a histological feature rarely documented in tumours of the upper urinary tract. Shadow cell differentiation, more commonly associated with skin-derived lesions such as pilomatrixoma, poses a significant diagnostic challenge when encountered in urothelial tumours, as it may lead to misclassification. This report highlights the importance of recognising atypical morphological patterns in upper-tract urothelial carcinoma to ensure accurate pathological diagnosis and appropriate clinical management.
Zhonghua bing li xue za zhi = Chinese journal of pathology
Source →Perioperative and survival outcomes of synchronous vs. metachronous upper tract urothelial carcinoma among bladder cancer patients treated with radical cystectomy and nephroureterectomy: Results from an International Multicenter Collaborative Study-On behalf of the Young Academic Urology (YAU) Urothelial Working Group.
Corvino R, et al
A multicenter retrospective study of 177 bladder cancer patients requiring both radical cystectomy (RC) and radical nephroureterectomy (RNU) found that synchronous upper tract urothelial carcinoma (UTUC) is associated with significantly worse perioperative and survival outcomes compared to metachronous disease. Patients undergoing concomitant RC and RNU experienced longer hospital stays (10 vs. 7 days, P=0.004) and a higher rate of major complications (Clavien-Dindo ≥ IIIa: 29.6% vs. 15.1%, P=0.03). At 60 months, metachronous disease showed superior disease-free survival (69.1% vs. 47.6%), cancer-specific survival (80.3% vs. 66.4%), and overall survival (69.2% vs. 47.6%), with metachronous presentation independently predicting better disease-free survival (HR 0.36, P<0.001) and overall survival (HR 0.53, P=0.04). These findings, drawn from 23 tertiary referral centers across 2002–2024, highlight the urgent need for individualized treatment and surveillance strategies in patients with pan-urothelial disease.
Urologic oncology
Source →💊 Therapies
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