Paraganglioma

C75.4-C75.5WHO Vol. 10

Endocrine & Neuroendocrine System

Prognosis

This section is being prepared by our editorial process.

🔬 Histological Types

📚 Latest Research

2026-09-07

Peptide Receptor Radionucleotide Therapy for Unresectable Paediatric Head and Neck Paraganglioma in Aotearoa New Zealand.

McCall M, et al

A paediatric patient with an unresectable glomus jugulare paraganglioma treated with peptide receptor radionuclide therapy (PRRT) achieved stable disease molecularly at 12 months and radiologically at 15 months post-treatment, demonstrating a meaningful clinical benefit from this targeted approach. Head and neck paragangliomas are frequently inoperable due to their proximity to vital structures, and approximately 30–40% are hereditary, often presenting at a younger age. This case from Aotearoa New Zealand adds to a growing body of literature supporting PRRT as a reasonable treatment option for this challenging tumour, while also highlighting that access to PRRT remains limited globally.

Case reports in otolaryngology

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2026-09-04

Primary mediastinal ectopic thyroid in a 43-year-old woman: A diagnostic and surgical challenge - a case report and literature review.

Wang Z, et al

Surgeons successfully diagnosed and completely resected a rare primary mediastinal ectopic thyroid (PMET) — a benign soft-tissue mass measuring approximately 49 × 37 × 56 mm — in an asymptomatic 43-year-old woman, with preoperative computed tomography angiography (CTA) proving critical for safe surgical planning. The mass was discovered incidentally on routine chest CT and presented a major diagnostic challenge due to imaging overlap with malignant conditions including thymic epithelial tumors, lymphoma, Castleman disease, and paraganglioma. CTA-based vascular mapping identified abundant tortuous feeding vessels coursing over the tumor surface adjacent to the left innominate vein, guiding the team to perform median sternotomy with sequential vessel clipping and ultrasonic shear division for complete resection. At approximately 11 months post-surgery, follow-up chest CT confirmed no recurrence and thyroid function remained normal, establishing preoperative CTA as an essential tool when hypervascular anterior mediastinal masses without cervical thyroid continuity are encountered.

Medicine

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2026-09-03

PPGLomics: An Interactive Platform for Pheochromocytoma and Paraganglioma Transcriptomics.

Alkaissi H, et al

Researchers have launched PPGLomics, a freely available interactive web platform designed to close a major gap in bioinformatics resources for pheochromocytoma and paraganglioma (PPGL), rare neuroendocrine tumors with exceptionally high heritability. The platform integrates two large, harmonized datasets — the TCGA-PCPG cohort (n=160) spanning multiple molecular subtypes and the A5 consortium SDHB cohort (n=91) with detailed clinicopathological annotations — providing tools for differential expression analysis, correlation analysis, survival analysis, and rich visualizations including heatmaps, volcano plots, and Kaplan-Meier survival curves. By requiring no bioinformatics expertise, PPGLomics empowers clinicians, basic scientists, and healthcare professionals alike to stratify PPGL subtypes and generate testable hypotheses, potentially accelerating discovery in a field where dedicated computational tools have been scarce.

Endocrine-related cancer

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