Cancer3.AI › AI in Oncology › Datasets › HLA Ligand Atlas
Dataset Open download CC BY 4.0

HLA Ligand Atlas

A benign-tissue reference peptidome: the set you check a candidate neoantigen against to make sure healthy tissue does not present it too.

Dataset site 📖 How it works { } JSON

At a glance

ProviderUniversity of Tübingen (Rammensee / Walz groups)
AccessOpen download
LicenceCC BY 4.0
class I ligands90 428
Size notes29 tissue types from 21 donors — benign tissue, which is what makes it a reference for what is NOT tumour-specific
FormatsCSV
Data typeImmunopeptidomics (MS-eluted peptides)
TaskAntigen presentation
CancerPan-cancer

Labels and annotations

Peptide, tissue, donor and HLA typing of the donor; multi-allelic by nature, so allele assignment requires deconvolution.

Details

Not yet documented on this card.

Models trained or evaluated on it

  • training NetMHCpan-4.1 Health Tech, Technical University of Denmark (Nielsen lab) — multi-allelic tissue peptidomes, deconvolved during training
  • training MixMHCpred 3.0 Gfeller lab, Ludwig Institute for Cancer Research / University of Lausanne

Sources

  1. Marcu A et al. HLA Ligand Atlas. J Immunother Cancer 2021

This page is educational — it is not medical advice and does not replace consultation with an oncologist. Diagnostic and treatment decisions are made solely by specialist physicians.