Latest Research
All publications from the Cancer3.AI database, newest first.
Gamma Knife Stereotactic Radiosurgery With a Reduced Peripheral Dose: Outcomes in Uveal Melanoma Patients.
Kollitz L, et al
Researchers evaluated a reduced-dose Gamma Knife stereotactic radiosurgery (GK SRS) protocol for treating uveal melanoma, a rare but serious eye cancer, in patients who were not suitable candidates for the standard plaque brachytherapy treatment. The study followed 24 adults with medium- or large-sized uveal melanoma who received a median peripheral radiation dose of 24 Gy, lower than doses used in many previously published protocols. Local tumor control was excellent, reaching 100% at one year and 95% at two years, with no statistically significant difference in control rates between medium and large tumors. Importantly, 83.3% of patients retained their eye, and nearly 70% maintained vision above the legal blindness threshold at one year, suggesting the reduced dose preserves visual function without significantly compromising tumor control. These findings indicate that 24 Gy may offer a favorable balance between effectiveness and safety, potentially sparing patients from more severe radiation-related side effects. The authors call for further studies to establish the optimal dose that best protects both tumor control and vision in uveal melanoma patients.
Advances in radiation oncology
Source →Cysticercus tenuicollis in selected locations in Poland: genetic diversity, prevalence and epidemiological patterns in roe deer (Capreolus capreolus) and moose (Alces alces).
Pyziel AM, et al
A new study published in the Journal of Veterinary Research investigated the prevalence, infection intensity, and genetic diversity of Cysticercus tenuicollis — the larval stage of the tapeworm Taenia hydatigena — in wild roe deer and moose across several Polish regions. Researchers examined 167 roe deer and 36 moose post mortem, using molecular analysis of the cox1 gene to identify and characterize the parasites. Results showed infection rates of approximately 9.6% in roe deer and 8.3% in moose, with cysts found most commonly in the omentum and mesentery, and a notable intraspecific genetic diversity of 1.42% among isolates. All detected infections were exclusively caused by T. hydatigena, and extrapolating these figures nationally suggests more than 18,000 roe deer in Poland may currently be infected. Although T. hydatigena does not infect humans, the parasite poses real economic and food safety concerns by causing condemnation of carcasses and organs during meat inspection. The authors recommend ongoing surveillance and advise against feeding raw game meat to dogs, which serve as definitive hosts and can spread the parasite to livestock.
Journal of veterinary research
Source →Multimodal imaging in conductive hearing loss: Optimising CT, MRI and CTA for accurate diagnosis and management.
Vlachodimitropoulos A, et al
A new review published in the SA Journal of Radiology examines how multiple imaging techniques can be combined to accurately diagnose and manage conductive hearing loss (CHL), a condition in which sound transmission through the outer or middle ear is impaired. High-resolution computed tomography (HRCT) is confirmed as the gold standard first-line imaging tool, offering exceptional detail of bony structures such as those affected by otosclerosis, ossicular chain disruptions, and trauma. MRI serves as a vital complement to HRCT by providing superior soft tissue contrast, particularly useful for detecting recurring cholesteatoma after surgery and characterising vascular tumours like glomus tympanicum. CT angiography (CTA) is recommended in selected cases involving vascular abnormalities to guide surgical planning. The review also stresses the importance of optimising scan protocols and minimising radiation exposure, especially in children. Together, these three imaging modalities form a structured, evidence-based framework that can significantly improve diagnostic accuracy and treatment outcomes for both paediatric and adult patients with conductive hearing loss.
SA journal of radiology
Source →Case report: endolymphatic sac tumor masquerading as Meniere's disease.
McHugh A, et al
A case report published in the International Journal of Surgery Case Reports describes a rare endolymphatic sac tumor (ELST) that was misdiagnosed as Menière's disease for a decade before the correct diagnosis was established. The patient presented with long-standing hearing loss, vertigo, and tinnitus — symptoms indistinguishable from Menière's syndrome — but eventually developed cranial nerve palsies affecting the facial, vestibulocochlear, and vagus nerves, prompting urgent surgical investigation. Advanced skull base imaging revealed aggressive features, and a multidisciplinary team of neuro-otologists, skull base surgeons, neuroradiologists, and pathologists collaborated to achieve a definitive histological diagnosis. This case highlights the significant diagnostic challenge posed by ELSTs, which are slow-growing tumors that can mimic benign inner ear conditions for years before revealing their true nature. Crucially, ELSTs are associated with von Hippel-Lindau syndrome, a hereditary condition predisposing patients to multiple tumors, making accurate diagnosis essential for broader patient management and genetic counseling. Clinicians working in skull base surgery must maintain awareness of this rare pathology to avoid prolonged misdiagnosis and ensure timely, appropriate intervention.
International journal of surgery case reports
Source →Conservative management for non-puerperal uterine inversion in nulliparous woman: a rare case report.
Milla H, et al
Researchers present a rare case of non-puerperal uterine inversion (NPUI) in a 40-year-old nulliparous woman who arrived in hemorrhagic shock due to severe vaginal bleeding and a protruding uterine mass, a condition not related to childbirth and extremely uncommon in gynecological practice. Diagnostic imaging confirmed the absence of the uterus in its normal abdominal position, prompting emergency stabilization followed by a combined abdominal-vaginal surgical approach. The surgical team performed a vaginal myomectomy to remove the underlying fibroid tumor, then repositioned the uterus using the Kustner technique with an extended incision, and completed the procedure with hysterorrhaphy to repair and preserve the uterus. The patient experienced no postoperative complications, and fertility preservation was successfully achieved. This case highlights that NPUI presents significant diagnostic and surgical challenges, but careful selection of surgical technique can allow uterine conservation even in complex presentations, which is especially important for patients who may wish to retain fertility.
International journal of surgery case reports
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