Latest Research
All publications from the Cancer3.AI database, newest first.
Renal Solitary Fibrous Tumor With Local Recurrence Following Complete Surgical Resection: A Case Report.
Panagopoulos PA, et al
Researchers from Cureus journal reported a rare case of a solitary fibrous tumor (SFT) originating in the kidney of an 81-year-old woman, a location considered extremely uncommon for this type of cancer. The tumor was discovered incidentally and removed via laparoscopic radical nephrectomy, with laboratory analysis confirming a malignant SFT classified as intermediate risk using the modified Demicco model. Despite clear imaging scans at the six-month follow-up, the tumor returned locally just one year after surgery, highlighting its unpredictable behavior. This case underscores that even apparently successful, complete surgical removal of renal SFTs does not guarantee freedom from recurrence. For clinicians, the findings reinforce the critical importance of long-term, vigilant monitoring for patients diagnosed with this rare kidney tumor.
Cureus
Source →REFCOR good practice guidelines for radiotherapy in sinonasal carcinomas and mucosal melanomas.
Thariat J, et al
French oncology network REFCOR has published comprehensive clinical guidelines defining the indications and standards for radiotherapy in sinonasal carcinomas and mucosal melanomas, two rare and aggressive cancers affecting the nasal cavity and paranasal sinuses. The guidelines were developed through multidisciplinary consensus, combining a systematic review of scientific literature with practical input from expert centers across France. Key findings establish that radiotherapy is most commonly delivered as an adjuvant treatment shortly after surgery, though it can also serve as the primary treatment for patients with unresectable tumors or surgical contraindications, with targets carefully tailored to tumor histology and disease stage. Given the anatomical proximity of sinonasal tumors to critical structures such as the optic pathways, brain, and inner ear, the guidelines strongly recommend advanced conformal techniques including IMRT and VMAT, with proton therapy considered when additional sparing of sensitive organs is needed. These evidence-based recommendations aim to standardize high-quality, personalized cancer care across France by ensuring all treatment decisions are reviewed by specialized multidisciplinary tumor boards within the REFCOR network. For clinicians and patients alike, these guidelines represent a significant step toward reducing treatment-related side effects while maximizing tumor control in these challenging malignancies.
European annals of otorhinolaryngology, head and neck diseases
Source →Malignant Melanoma as a Rare Cause of Penile Cancer: A Case Report.
Guarda D, et al
Researchers report a rare case of malignant melanoma occurring on the penis of a 47-year-old man, a condition that accounts for only a small fraction of all penile cancers. The patient initially experienced itching and a growing lesion on the glans penis, which later progressed to severe pain and swollen lymph nodes in both groins. Biopsy confirmed the diagnosis of penile malignant melanoma, and imaging revealed that the disease had already spread to regional lymph nodes and internal organs at the time of diagnosis. The patient received a combination of surgery and systemic therapy following evaluation by a multidisciplinary medical team. This case highlights that melanoma should be considered in the differential diagnosis of unusual penile lesions, as early recognition is essential to improving patient outcomes in this aggressive and rarely encountered malignancy.
Cureus
Source →The Evolving Landscape of Anti-Clonal Therapy in Newly Diagnosed Systemic Light-Chain (AL) Amyloidosis: Evidence- and Time-Based Comparison with Multiple Myeloma.
Ríos-Tamayo R
A new review published in Life (Basel) examines the evolving landscape of anti-clonal therapy for newly diagnosed systemic light-chain (AL) amyloidosis, a rare and currently incurable plasma cell disorder, comparing it to treatment advances in the closely related condition of multiple myeloma (MM). AL amyloidosis shares key biological features with MM, including the accumulation of abnormal plasma cells in the bone marrow, and approximately one in five newly diagnosed AL amyloidosis patients also meets diagnostic criteria for MM. The review traces the comparative development of treatment strategies since the introduction of bortezomib, highlighting how breakthroughs in MM therapy have been progressively adapted for carefully selected AL amyloidosis patients, leading to meaningfully improved outcomes. The authors emphasize that anti-clonal therapy forms the cornerstone of hematological treatment for AL amyloidosis, complemented by supportive care and emerging anti-fibril therapies targeting the disease's unique protein deposits. For clinicians, the review underscores the importance of a multidisciplinary approach and strongly advocates for patient enrollment in clinical trials as the preferred first step in daily practice.
Life (Basel, Switzerland)
Source →The Salivary Tumor That Lost Its Way: A Case Report of Sinonasal Pleomorphic Adenoma.
O'Brien Á, et al
This case report describes a rare occurrence of pleomorphic adenoma (PA), a typically benign salivary gland tumor, found unexpectedly in the nasal cavity of a 46-year-old man. The patient, who also had primary ciliary dyskinesia and type 2 diabetes, presented with bilateral nasal obstruction and chronic rhinosinusitis, and was initially treated for nasal polyps via endoscopic sinus surgery. Routine histological analysis of the removed tissue revealed the characteristic biphasic cellular architecture of PA, and advanced RNA sequencing identified an NCALD::PLAG1 gene fusion, confirming the salivary gland origin of the tumor. This molecular finding is significant because PLAG1 gene alterations are a hallmark of pleomorphic adenoma, providing definitive diagnostic confirmation in an atypical location. The case highlights the importance of including PA in the differential diagnosis when evaluating nasal masses or unexplained nasal obstruction, even when a more common condition seems likely. Clinicians are advised to pursue complete surgical excision and long-term follow-up for such patients, given the risk of tumor recurrence or malignant transformation over time.
Cureus
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