Latest Research
All publications from the Cancer3.AI database, newest first.
Risk Factors and Predictive Model for Peripherally Inserted Central Catheter Tip Migration in Patients With Bladder Cancer.
Zheng K, et al
Researchers investigated the risk factors behind peripherally inserted central catheter (PICC) tip migration—a potentially serious complication—in 280 bladder cancer patients receiving chemotherapy via PICC lines at a single institution between 2021 and 2023. Using statistical techniques including LASSO regression and multivariate logistic regression, the team identified five independent risk factors: body mass index (BMI), abnormal initial catheter tip position, how long the catheter remained in place, the number of insertion attempts required, and the range of motion in the limb carrying the catheter. Among several machine learning models tested—including random forest, support vector machine, and K-nearest neighbour algorithms—the random forest model performed best, achieving an area under the curve (AUC) of 0.768 in the training set and 0.738 in the validation set, indicating good predictive accuracy. The researchers also used SHAP (SHapley Additive exPlanations) values and a visual nomogram to make the model transparent and clinically usable, highlighting limb range of motion, BMI, and catheter duration as the most influential predictors. This predictive tool could help nurses and oncologists identify high-risk patients early, enabling timely adjustments to catheter management and reducing preventable complications during chemotherapy.
Archivos espanoles de urologia
Source →Comparative Study of the Efficacy and Complications of Urethral Realignment and Primary Urethral Anastomosis for Traumatic Urethral Injuries in Emergency Surgical Management.
Wang Z, et al
A new retrospective study from Fuyang People's Hospital in China compared two surgical approaches for traumatic urethral injuries (TUI), a serious urological emergency often caused by pelvic trauma: urethral realignment and primary urethral anastomosis. Analyzing 129 patients treated between 2022 and 2024, researchers found that urethral realignment was faster, caused less blood loss, produced lower pain scores, and triggered a smaller inflammatory response in the immediate postoperative period. However, primary urethral anastomosis demonstrated clearly superior long-term outcomes, including better urinary flow rates, lower post-void residual volumes, higher erectile function scores, and a significantly lower rate of urethral stricture (5.17% versus 18.31%). These findings suggest that the choice of surgical technique should be guided by the patient's overall condition and clinical priorities: realignment may be preferable in unstable or complex emergencies, while anastomosis offers better functional recovery for suitable candidates.
Archivos espanoles de urologia
Source →[Robotic Colorectal Surgery in Israel - An Institutional Learning Curve and a Glance to the Future].
Anuka E, et al
Researchers at an Israeli medical institution conducted a two-year retrospective study examining the introduction and outcomes of robotic-assisted colorectal surgery using the Da Vinci system between January 2023 and February 2025. A total of 41 robotic colorectal procedures were performed, with the majority — 30 cases — carried out for oncological indications such as colorectal cancer. Key complications included two cases of anastomotic leaks requiring reoperation, one case of bowel ischemia, and one ureteral thermal injury managed with a stent, while no deaths were recorded during the study period. Notably, the surgical team demonstrated a consistent reduction in operating times for right hemicolectomy and sigmoidectomy over the study period, reflecting a clear institutional learning curve. These findings suggest that with structured training, careful patient selection, and expert mentorship, robotic colorectal surgery can be safely introduced into a general surgery department with complication rates comparable to established standards. The study offers important guidance for other Israeli and regional institutions considering the adoption of robotic platforms in colorectal and rectal surgery.
Harefuah
Source →Comment on: Fertility Preservation in Extramedullary Plasmacytoma of the Uterine Cervix: Global Literature Synthesis and First Case From Iran-Proposing a Standardized 'Fertility-Risk Stratification Tool' for Young Patients With Rare Cervical Plasma Cell Neoplasms.
Ma Y, et al
This commentary addresses the rare condition of extramedullary plasmacytoma occurring in the uterine cervix, focusing specifically on fertility preservation challenges for young women diagnosed with this unusual plasma cell malignancy. The authors respond to a global literature synthesis and the first reported Iranian case, highlighting the scarcity of evidence guiding clinical decisions in this setting. A central contribution of the commentary is the proposal of a standardized 'Fertility-Risk Stratification Tool' designed to help clinicians categorize young patients according to their reproductive risk and tailor treatment accordingly. The tool aims to balance oncological control with the preservation of fertility, an especially pressing concern given that standard treatments for plasma cell neoplasms can render patients infertile. This work matters because the extreme rarity of cervical plasmacytoma means that no established guidelines exist, leaving clinicians without a systematic framework when counseling young patients who wish to conceive. By synthesizing existing cases and introducing a structured decision-making instrument, the authors provide a practical resource that could improve both oncological and reproductive outcomes in this vulnerable patient group.
The journal of obstetrics and gynaecology research
Source →Ten-Year Outcome of a Patient With Concurrent Pelvic Myeloid Sarcoma and Underlying Chronic Myeloid Leukaemia in Chronic Phase: A Case Report and Literature Review.
Yong KY, et al
Researchers report a remarkable ten-year case study of a patient diagnosed simultaneously with chronic myeloid leukaemia in chronic phase (CML-CP) and a rare solid tumour called myeloid sarcoma located in the pelvis. Standard intensive chemotherapy used for acute myeloid leukaemia proved ineffective, but a combination of radiotherapy and a targeted drug class known as tyrosine kinase inhibitors led to a sustained, deep molecular remission. The patient has remained well for a full decade without requiring allogeneic stem cell transplantation, which is a significant and encouraging outcome for such a rare and complex presentation. This is the first documented case of myeloid sarcoma concurrent with CML-CP achieving such long-term remission through this treatment approach, and the authors also reviewed existing literature to better characterize the disease and its outcomes. The findings suggest that radiotherapy combined with tyrosine kinase inhibitors may be a viable and less aggressive alternative to transplantation for selected patients with this rare combination of blood and solid tumour malignancies.
Cancer reports (Hoboken, N.J.)
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