Latest Research
All publications from the Cancer3.AI database, newest first.
Case Report: Thoracoscopic secondary cytoreductive surgery for high-grade serous ovarian cancer.
Turco LC, et al
This case report, published in Frontiers in Surgery, demonstrates the use of video-assisted thoracoscopic surgery (VATS) as a minimally invasive approach to secondary cytoreductive surgery in a patient with recurrent high-grade serous ovarian cancer. The recurrence involved cardiophrenic lymph nodes and the right diaphragm with extension to the right basal pleura, which are challenging anatomical locations typically associated with complex surgical procedures. Using thoracoscopy, surgeons were able to safely dissect and remove the thoracic tumor deposits without resorting to open chest surgery. The minimally invasive approach proved both safe and technically feasible, resulting in rapid postoperative recovery for the patient. Importantly, the quicker recovery allowed the patient to promptly begin second-line adjuvant chemotherapy, which is a critical factor in managing recurrent ovarian cancer. This case highlights that thoracoscopic cytoreduction may be a valuable option for carefully selected patients with thoracic recurrences of ovarian cancer.
Frontiers in surgery
Source →Protein-based nanocarriers in the management of hard-to-treat solid tumours.
Evtushenko AS, et al
Researchers conducted a comprehensive critical review of protein-based nanocarriers (NCs) as drug delivery systems for hard-to-treat cancers, including lung, liver, oesophageal, pancreatic, and brain tumours, which continue to have dismally low survival rates despite overall progress in cancer treatment. The review examined the full landscape of protein-based NCs, with particular focus on albumin-based formulations such as nab-paclitaxel, the only clinically approved protein-based NC in oncology, which has been in use since 2005. The authors found that development in this field has largely stagnated due to poorly understood drug uptake mechanisms, reproducibility challenges, immunogenicity concerns, and limitations of conventional manufacturing methods such as desolvation and homogenisation. Beyond albumin, twelve other proteins have been explored for NC formulation in these difficult cancers, yet none have successfully advanced to clinical trials. The review highlights practical strategies to overcome these barriers, including improving tumour targeting, optimising drug cargo selection, and strengthening preclinical validation, with the ultimate goal of bringing new protein-based nanomedicines to patients with currently limited treatment options.
Advanced drug delivery reviews
Source →Successful conversion therapy of advanced gallbladder carcinoma by chemotherapy combined with immunotherapy: two case reports.
Li L, et al
Researchers at Xiangyang Central Hospital in China reported two cases of advanced gallbladder cancer — one of the most aggressive cancers of the digestive system — that was initially considered inoperable due to the extent of disease. Both patients received a combination of chemotherapy and immunotherapy, which produced significant shrinkage of tumors at both the primary site and metastatic locations, meeting the criteria for partial remission. This tumor reduction, known as conversion therapy, made it possible for surgeons to perform successful radical resections in both cases. After surgery, the combined treatment regimen was continued for five additional cycles, and follow-up through November 2025 showed no signs of cancer recurrence in either patient. These cases suggest that chemotherapy combined with immunotherapy may offer a viable pathway to curative surgery for select patients with advanced gallbladder cancer who would otherwise have no surgical options.
Frontiers in oncology
Source →Clinicopathological and Radiological Profile of Gallbladder Carcinoma: A Cross-Sectional Study From a Tertiary Care Center in Tripura, India.
Gudimetla GK, et al
Researchers at Agartala Government Medical College in Tripura, India, conducted a prospective cross-sectional study to characterize the clinical, pathological, and radiological features of gallbladder carcinoma in a region with historically limited data. The study enrolled 104 confirmed patients between May 2024 and November 2025, collecting detailed information on demographics, symptoms, tumor markers, imaging findings, and staging according to AJCC 8th edition criteria. A striking female predominance was identified (88.5%), with most patients being over 60 years old, from rural backgrounds, and belonging to lower socioeconomic groups. The majority of patients presented at an advanced stage, with nearly 70% having T3 or T4 tumors, 64% showing lymph node involvement, and over 40% classified as Stage IVB — the most severe category. Elevated tumor markers CA 19-9 and CEA were common, and CECT scanning proved superior to ultrasound in detecting mass lesions. These findings highlight the urgent need for improved early detection strategies and awareness programs in northeastern India, where late-stage presentation severely limits treatment options and survival outcomes.
Cureus
Source →How I Do It: A Stepwise Surgical Technique for Fisch Class B Glomus Tympanicum.
Gargula S, et al
Researchers at a specialized surgical center have described a detailed, step-by-step microsurgical technique for removing Fisch Class B glomus tympanicum tumors, which are benign but highly vascular growths arising in the middle ear. The approach combines a retroauricular incision with circumferential canaloplasty and the temporary removal of the tympanomeatal flap and the malleus bone to create wider operative access. This sequenced workflow enables surgeons to identify critical anatomical structures early, progressively cut off the tumor's blood supply, and safely excise even large lesions that extend into the lower or front compartments of the middle ear space. By emphasizing operative sequencing and surgical ergonomics, the technique aims to reduce intraoperative bleeding and minimize the risk of damage to hearing structures and adjacent nerves. The publication provides clinicians with a reproducible, structured framework for managing these technically demanding cases, potentially improving surgical outcomes and reducing complication rates for patients with bulky tympanic paragangliomas.
The Laryngoscope
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