Latest Research
All publications from the Cancer3.AI database, newest first.
PET/MRI with 89Zr-labelled antibodies provides insights into altered antibody pharmacokinetics in the chick embryo model.
Benčurová K, et al
Researchers investigated whether fertilised chicken eggs (in ovo model) could serve as an ethical and practical intermediate testing platform for radiolabelled antibodies used in PET/MRI imaging, a technique important for cancer diagnosis and drug development. The team synthesised two zirconium-89-labelled antibodies — Denosumab and Atezolizumab — with high purity and tracked their movement through chick embryos using simultaneous PET and MRI scanning. Both antibodies were cleared from the body much faster than typically observed in mammals, with most radioactivity accumulating in the gallbladder within 19–23 hours, indicating rapid hepatobiliary excretion. This accelerated clearance was attributed to the absence of neonatal Fc receptors (FcRn) in birds, which in mammals recycle IgG antibodies and significantly extend their half-life in circulation. The findings reveal a fundamental biological difference between avian and mammalian systems that critically limits how well the chick embryo model can predict antibody behaviour relevant to human cancer imaging and therapy. Scientists caution that while the in ovo model remains promising for some radiotracer classes, species-specific differences must be carefully considered before extrapolating results to clinical settings.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Source →Association of Green Tea Consumption and the Risk of Liver Cancer Incidence among Japanese Adults.
Funabashi O, et al
A large prospective cohort study from Japan investigated whether drinking green tea is associated with a reduced risk of developing liver cancer. Researchers followed nearly 42,000 adults aged 40–79 years for up to 21 years as part of the Japan Collaborative Cohort (JACC) Study, tracking their green tea consumption habits and liver cancer diagnoses. The results showed that people who drank seven or more cups of green tea per day had a 39% lower risk of liver cancer compared to those who drank less than one cup per day, with a statistically significant dose-response trend. The protective association was strongest among men, current alcohol drinkers, and individuals without a prior history of liver disease. The study also estimated that approximately 7% of liver cancer cases in the population could potentially be attributed to low green tea consumption. These findings suggest that regular, high-level green tea consumption may be a practical and accessible lifestyle factor that could contribute to liver cancer prevention, though further research is needed to confirm causality.
Asian Pacific journal of cancer prevention : APJCP
Source →Endoscopic Ultrasound-Guided Gallbladder Drainage Using a 19-Gauge Needle and a Modified Slim Metal Stent: A Simplified Approach (With Video).
Chuncharunee A, et al
Researchers describe a simplified endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) technique using a 19-gauge Franseen-tip needle and a modified slim fully covered self-expandable metal stent (FCSEMS) for patients with acute cholecystitis caused by malignant biliary obstruction. The study enrolled 18 consecutive patients between 2022 and 2025, all of whom were considered unsuitable for surgery due to their underlying cancer. Both the technical and clinical success rates were 100%, meaning the procedure was successfully performed in every patient and effectively relieved their cholecystitis each time. Over a median follow-up of six months, only one patient experienced a recurrence of cholecystitis, which was managed endoscopically, and no severe complications or 30-day deaths occurred. These results suggest that this streamlined needle-to-stent approach offers a safe and effective minimally invasive alternative for a vulnerable cancer population that currently has limited treatment options.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Source →Management of ERCP Failure in Malignant Biliary Obstruction: Comparative Effectiveness and Safety of EUS-Guided Gallbladder Drainage Versus Choledocoduodenostomy.
Mangiavillano B, et al
A large international study investigated the best endoscopic rescue strategy for patients with malignant distal biliary obstruction (a blockage of the bile duct caused by cancer) when standard ERCP drainage fails. Researchers at 28 tertiary-care centers compared two ultrasound-guided techniques: gallbladder drainage (EUS-GBD) and a direct connection between the bile duct and the duodenum (EUS-CDS), both performed using specialized metal stents. After analyzing 529 patients and applying statistical matching to ensure fair comparison, both procedures achieved nearly identical rates of technical success (97.3% vs 91%) and clinical success (83% vs 85.7%), with no statistically significant differences in complication rates or survival. Adverse events occurred in roughly 20% of EUS-GBD patients and 12.5% of EUS-CDS patients, though this difference did not reach statistical significance, and no treatment-related deaths were recorded in either group. These findings provide clinicians with reassurance that EUS-guided gallbladder drainage is a safe and effective alternative when bile duct access is not possible, particularly in patients who still have their gallbladder and an open cystic duct.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Source →Old Dogs Can Learn New Tricks: Artificial Intelligence Improves Adenoma Detection Rates in Screening Colonoscopies in Experienced Endoscopists.
Cholyway RM, et al
Researchers at a single tertiary referral institution investigated whether artificial intelligence-powered computer-aided detection (CADe) systems could improve adenoma detection rates (ADR) during screening colonoscopies, with a particular focus on whether the benefit would differ by endoscopist experience and procedure volume. The study retrospectively compared 1,285 colonoscopies performed before CADe implementation with 1,042 performed after, involving 24 endoscopists including both colorectal surgeons and gastroenterologists. Overall, the mean ADR rose significantly from 53.9% to 61.3% following CADe adoption, representing a clinically meaningful improvement in polyp identification. Notably, the greatest statistically significant gains were observed among colorectal surgeons, senior endoscopists, and high-volume practitioners — contradicting the initial hypothesis that less experienced or lower-volume endoscopists would benefit most. These findings suggest that AI-assisted colonoscopy can meaningfully enhance performance even among experienced clinicians, potentially reducing the risk of post-colonoscopy colorectal cancer across a broad range of practitioners. The results support wider adoption of CADe technology in endoscopy units, though larger multi-center studies are needed to confirm long-term impact on colorectal cancer incidence.
Diseases of the colon and rectum
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