Latest Research
All publications from the Cancer3.AI database, newest first.
A 71-Year-Old Woman With Dyspnea and Hypoxemia After Liver Metastases Cryoablation.
Martinez Manzano JM, et al
This case report from the journal Chest presents a 71-year-old woman with a complex oncological history, including metastatic non-small cell lung cancer managed over a decade with left-side pneumonectomy, stereotactic body radiation therapy, and long-term targeted therapy with sotorasib targeting the KRAS G12C mutation. The patient developed new-onset dyspnea and hypoxemia following cryoablation of liver metastases, prompting a pulmonary evaluation. The case highlights the diagnostic and management challenges that arise when a patient with severely reduced baseline pulmonary reserve — due to prior pneumonectomy and radiation — undergoes an interventional oncologic procedure. Clinicians are reminded that procedural complications, including pulmonary or systemic effects following cryoablation, can have exaggerated and life-threatening consequences in patients with limited respiratory capacity. This report underscores the importance of thorough pre-procedural pulmonary risk assessment in cancer patients with prior thoracic surgery and radiation. It serves as a valuable clinical teaching case for pulmonologists and oncologists managing patients with compounding comorbidities and prior aggressive thoracic treatments.
Chest
Source →Multidisciplinary evaluation improves prevalence of testis-sparing surgery in children with testicular benign tumors: a cross-section study.
Guo B, et al
This cross-sectional study investigated whether a multidisciplinary team approach could improve the rate of testis-sparing surgery (TSS) in pediatric patients diagnosed with benign testicular tumors. Researchers evaluated how structured collaboration among pediatric surgeons, urologists, radiologists, and oncologists influenced surgical decision-making compared to standard single-specialist care. The findings demonstrated that multidisciplinary evaluation significantly increased the prevalence of organ-preserving procedures, reducing the number of unnecessary radical orchiectomies in children. This is particularly important because preserving testicular tissue in young patients helps protect future fertility and hormonal function. The study highlights that institutional adoption of multidisciplinary tumor boards for pediatric testicular masses should be considered a standard of care to avoid overtreatment of benign lesions.
BMC cancer
Source →X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer.
Gadad SS, et al
Researchers studying breast cancer have discovered a previously unknown protein called XCP (X-linked Cancer-associated Polypeptide), encoded by a gene previously classified as noncoding RNA. The study found that XCP is highly expressed in three major molecular subtypes of breast cancer — luminal A, luminal B, and HER2-positive — and promotes tumor cell growth both in cell culture models and in animal xenograft experiments. XCP exerts its cancer-promoting effects by interacting with and stimulating the activity of PHF8, a histone demethylase enzyme that chemically modifies the proteins around which DNA is wound, thereby altering which genes are switched on or off in cancer cells. This discovery reveals a new molecular mechanism by which breast cancer cells hijack epigenetic control of gene expression, with XCP acting as a key co-regulator of PHF8 on chromatin. The findings challenge the assumption that noncoding RNAs are functionally inert and suggest that XCP and PHF8 could serve as novel therapeutic targets in breast cancer treatment.
Oncogene
Source →In Reply.
Braga A, et al
This publication is a reply letter published in the journal Obstetrics and Gynecology, representing a correspondence piece rather than an original research study. Reply letters in peer-reviewed journals typically respond to comments, critiques, or questions raised about a previously published article. Without an accompanying abstract or detailed content, the specific subject matter of the original study and the nature of the reply cannot be fully characterized. Such correspondence contributes to ongoing scientific dialogue and helps clarify findings, address methodological concerns, or provide additional context for clinicians and researchers in the field of obstetrics and gynecology. The publication underscores the importance of open academic exchange in advancing women's health research.
Obstetrics and gynecology
Source →Integrated multi-regional multiomic profiling of breast phyllodes tumours reveals peritumoural immune activation and stromal remodelling.
Gu T, et al
Researchers conducted an integrated multi-regional study of breast phyllodes tumours, a rare and aggressive type of breast cancer originating from stromal cells, by collecting 66 tissue specimens from 22 patients representing benign, borderline, and malignant subtypes. Using genomic, transcriptomic, and digital pathology analyses alongside multiplex immunofluorescence, they examined both the tumour core and the surrounding peritumoural tissue to map spatial patterns of tumour evolution. A striking finding was that malignant phyllodes tumours display a paradoxical immune landscape: the peritumoural region is rich in immune cells and shows active blood vessel formation and collagen remodelling, while the tumour core itself is largely devoid of immune infiltration, a pattern known as immune exclusion. Patients with more pronounced spatial immune segregation appeared to have a lower risk of tumour recurrence, suggesting this feature carries prognostic significance. These discoveries identify the peritumoural microenvironment as a biologically active and therapeutically relevant zone, and the authors propose that combining anti-angiogenic agents with immunotherapy could help overcome the immune-excluded state of malignant phyllodes tumours and improve patient outcomes.
Clinical and translational medicine
Source →