Latest Research
All publications from the Cancer3.AI database, newest first.
Associations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease.
Zeng W, et al
A new study published in Neurosurgery examined the lifetime risk of neuropsychiatric disorders in patients with Cushing's disease, a rare condition caused by a hormone-secreting pituitary tumor that leads to excess cortisol, and investigated whether surgical removal of the tumor could reduce that risk. Using a large U.S. database covering over 6.4 million patients across 144 healthcare organizations, researchers found that Cushing's disease patients face dramatically higher rates of anxiety, major depression, persistent mood disorders, and sleep disorders compared to both the general population and patients with non-functioning pituitary tumors. Critically, patients who underwent transsphenoidal surgery — a minimally invasive procedure to remove the pituitary tumor through the nasal passage — showed significantly lower risks of anxiety disorders, major depressive disorder, depressive episodes, sleep disorders, and substance use disorders compared to those who did not have surgery. For example, surgical patients had a 42% lower risk of major depressive disorder and a 40% lower risk of generalized anxiety disorder. These findings highlight the importance of timely surgical intervention not only for controlling hormone levels but also for protecting long-term mental health in Cushing's disease patients. Clinicians treating this population should be aware of the substantial psychiatric burden of the disease and consider surgery as a strategy to mitigate these comorbidities.
Neurosurgery
Source →Corrigendum: Sellar Dermoid Cyst Coexistence with Pituitary Adenoma/Pituitary Neuroendocrine Tumor.
Yip C, et al
This publication is a corrigendum — a formal correction notice — issued for a previously published case report examining the rare coexistence of a sellar dermoid cyst alongside a pituitary adenoma, also known as a pituitary neuroendocrine tumor. Sellar dermoid cysts are benign, congenital lesions that develop in the region of the sella turcica at the base of the brain, and their simultaneous occurrence with pituitary tumors is exceptionally uncommon. The correction addresses an error identified in the original article published in the same journal, ensuring the scientific record remains accurate and reliable. While the corrigendum itself does not introduce new findings, maintaining accuracy in rare case reports is clinically important, as such cases inform surgeons and endocrinologists about diagnostic and surgical considerations when encountering complex sellar region pathology.
Journal of neurological surgery reports
Source →Transition from Microsurgical to Endoscopic Endonasal Resection of Pituitary Adenomas: Early Experience and Learning Curve from a Single-Center Cohort in Vietnam.
Van Tuan N, et al
Researchers at People's Hospital 115 in Vietnam examined early outcomes after transitioning from traditional microscopic surgery to endoscopic endonasal transsphenoidal surgery (EETS) for the removal of pituitary adenomas, a common type of brain tumor affecting the pituitary gland. The study followed 47 consecutive patients treated between January 2023 and June 2025, most of whom had nonfunctioning tumors and were middle-aged women. Surgeons achieved greater than 80% tumor removal in 74% of patients overall, and notably this success rate improved from 61% early in the series to 88% later, suggesting a meaningful learning curve as the surgical team gained experience with the new technique. Visual symptoms improved in nearly all evaluable patients (98%), and serious complications were rare, with no deaths recorded. These findings indicate that a well-resourced neurosurgical center in a middle-income country can successfully implement advanced endoscopic pituitary surgery with outcomes comparable to international benchmarks, even during the initial transition period. The results are encouraging for other centers in Southeast Asia and similar settings considering adoption of endoscopic endonasal approaches.
World neurosurgery
Source →Xanthomatous Meningioma-An Uncommon Histopathological Subtype.
Jindal A, et al
This publication examines xanthomatous meningioma, a rare histopathological subtype of meningioma characterized by the presence of lipid-laden foamy cells within the tumor tissue. Meningiomas are among the most common primary brain tumors, yet xanthomatous variants represent only a small fraction of diagnosed cases, making their recognition challenging for pathologists. The study highlights the distinctive microscopic features that distinguish this subtype from more common meningioma variants and from other xanthomatous lesions of the central nervous system. Accurate identification of xanthomatous meningioma is clinically important because misclassification can affect treatment planning and prognostic assessment. Awareness of this uncommon subtype among surgical pathologists and neurosurgeons may lead to more precise diagnoses and better-informed patient management decisions.
International journal of surgical pathology
Source →Skull Base Reconstruction after Endonasal Endoscopic Resection of Synchronous Sinonasal Adenoid Cystic Carcinoma and Intracranial Meningioma.
Jurlina M, et al
Surgeons at a specialized center successfully removed two simultaneous skull base tumors in a single patient using an advanced endoscopic technique: a malignant adenoid cystic carcinoma of the sinonasal region and a benign intracranial meningioma that had grown into direct contact with each other. Because the two tumors had already breached the barrier between the nasal passages and the skull base, the surgical team chose to resect both tumors at the same time rather than attempt to preserve that boundary. A key challenge in such surgery is sealing the resulting large defect to prevent life-threatening leakage of cerebrospinal fluid into the nasal cavity, and the team pioneered the use of a free temporalis muscle fascia graft for this reconstruction via the endoscopic route, a technique previously reported only in open surgery. Complete tumor removal with negative margins was achieved in all directions around the defect, representing an optimal oncological outcome. This case expands the toolkit available to skull base surgeons and demonstrates that free temporalis muscle fascia grafts can serve as a viable alternative to standard graft materials in complex endoscopic skull base reconstruction.
Journal of neurological surgery reports
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