Latest Research
All publications from the Cancer3.AI database, newest first.
[Solid pseudopapillary tumor of the pancreas combined with serous cystadenoma: report of a case].
Su YS, et al
This publication presents a case report describing an exceptionally rare simultaneous occurrence of two distinct pancreatic tumors: a solid pseudopapillary tumor (SPT) and a serous cystadenoma found in the same patient. Solid pseudopapillary tumors are uncommon low-grade malignant neoplasms that primarily affect young women, while serous cystadenomas are benign cystic lesions of the pancreas, and their co-existence in a single patient is extraordinarily uncommon. The case was documented in detail from a pathological perspective, examining the histological and likely immunohistochemical features that allowed definitive diagnosis of both tumor types. This report highlights the diagnostic challenges clinicians and pathologists face when evaluating complex pancreatic masses, as the coexistence of two separate neoplasms can complicate preoperative imaging interpretation and surgical planning. Awareness of such rare combinations is important for pathologists and surgeons to ensure accurate diagnosis and appropriate patient management.
Zhonghua bing li xue za zhi = Chinese journal of pathology
Source →Proliferation and Apoptosis Adaptor Protein 15 (PEA15), a Potential Oncogenic Regulator of VHL and HIF1A Identified through Proteomic Analysis in Hepatocellular Carcinoma.
Jeong YS, et al
Researchers investigated why the HIF1A oxygen-sensing pathway — a key driver of liver cancer progression — remains abnormally active in hepatocellular carcinoma (HCC) even though mutations in its usual regulator, the VHL tumor suppressor gene, are rare in this cancer type. Through proteomic and genomic analysis of over 1,000 HCC tumor samples, scientists identified a protein called PEA15 as a novel oncogene that is selectively amplified in an aggressive HCC subtype termed mesenchymal, which carries the worst patient prognosis. Mechanistically, PEA15 physically binds to VHL and disrupts its interaction with a protein complex responsible for tagging HIF1A for destruction, thereby allowing HIF1A to accumulate and drive tumor cell growth and migration. Crucially, the researchers demonstrated that silencing PEA15 using antisense oligonucleotide (ASO) drugs — a clinically validated therapeutic approach — reduced tumor burden and restored normal VHL function in mouse xenograft models. These findings identify PEA15 as a potential therapeutic target and offer a new strategy to combat a particularly lethal form of liver cancer that currently lacks effective targeted treatments.
Cancer communications (London, England)
Source →A Practical Algorithm for Donor- and Recipient-site Selection in Vascularized Lymph Node Transfer in Extremity Lymphedema.
Kappos EA, et al
Researchers developed an evidence-based algorithm to guide surgeons in selecting the best donor and recipient sites for vascularized lymph node transfer (VLNT), a surgical procedure that transplants healthy lymph nodes to treat chronic limb lymphedema. Analyzing 161 patients treated between 2016 and 2023, the study found that all four donor sites tested — groin, lateral thoracic, mesenteric, and omental — produced comparable long-term reductions in limb swelling, meaning surgeons should choose based on minimizing patient risk rather than expected effectiveness. Recipient-site placement, however, had a major impact on outcomes: for upper extremity lymphedema, placing nodes near the armpit (axilla) produced faster and greater volume reductions than placement in the forearm, while for lower extremity lymphedema, placement in the lower leg outperformed placement in the groin area. Complications were rare overall (8.7%) and occurred only in patients who received groin- or thoracic-based flaps, further supporting risk-based donor-site selection. The authors also suggest that release of scar tissue during surgery may play a more important role in improving outcomes than previously appreciated. This practical algorithm offers clinicians a clearer, data-driven framework for personalizing VLNT surgery and improving results for lymphedema patients.
Plastic and reconstructive surgery. Global open
Source →Clinical significance of circulatory microRNA-183_5p and 3651 in serum as novel potential diagnostic marker for gallbladder cancer.
Verma D, et al
Researchers investigated whether two small molecules found in blood, called microRNAs (miR-183-5p and miR-3651), could serve as non-invasive diagnostic markers for gallbladder cancer, a deadly malignancy particularly prevalent in Asia that is often detected too late for effective treatment. The study, conducted at a single center, first used microarray technology to scan gallbladder tissue and identify differentially expressed microRNAs, then measured the levels of the selected candidates in serum samples from 130 participants including gallbladder cancer patients, gallbladder stone patients, and healthy controls. Both miR-183-5p and miR-3651 were significantly overexpressed in cancer patients, with miR-3651 showing a striking 5.6-fold increase, and their diagnostic accuracy—measured by the area under the curve (AUC of 0.752 for miR-3651)—exceeded that of the established tumor markers CEA and CA19.9. These findings suggest that serum microRNAs, particularly miR-3651, could offer a more accurate, blood-based alternative to current diagnostic approaches, potentially enabling earlier detection of gallbladder cancer and improving patient survival outcomes.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Source →Vector Physics Applied: A Strategic Approach to Optimized Retraction in Robotic Liver Surgery.
Kawano F, et al
Researchers developed a vector-based retraction strategy to overcome a key challenge in robotic liver surgery: the limited number of robotic arms available to hold tissue out of the way during complex operations. The team used patient-specific 3D liver models reconstructed from CT scans to plan and simulate optimal traction directions before each procedure. Intraoperatively, they combined four complementary retraction techniques—ligament-based traction, gallbladder traction, externalized sutures with adjustable tension, and dynamic robotic arm retraction—to achieve stable, clear views of the surgical cutting plane. Three distinct traction patterns were demonstrated and shown to provide consistent visualization during parenchymal transection, including during major liver removal procedures. This multimodal approach offers surgeons a reproducible, systematic framework for improving exposure and safety in robotic liver surgery, potentially reducing operative complications and broadening the range of patients who can benefit from minimally invasive hepatic resection.
Annals of surgical oncology
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