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Nature Cancer
2026-04-21
TMEM87A suppresses ferroptosis and increases cancer immunotherapy resistance by maintaining the Golgi apparatus pH homeostasis
Researchers publishing in Nature Cancer have identified the protein TMEM87A as a key regulator of Golgi apparatus pH homeostasis that protects cancer cells from ferroptosis, a form of iron-dependent cell death driven by lipid peroxidation. The study by Li et al. demonstrates that TMEM87A counteracts ferroptosis-induced lipid peroxidation in the Golgi, and that its presence in tumors contributes to…