News
Curated oncology headlines from reputable sources, ranked by importance with Claude Opus 4.7.
[Articles] Estimating the impact of scaling up workforce personnel on global cancer mortality from 2030 to 2050: a simulation-based analysis of 17 cancers and 18 personnel types
A simulation-based study published in The Lancet Oncology modeled the potential impact of scaling up the oncology workforce across 18 personnel categories on mortality from 17 cancer types between 2030 and 2050. The analysis found that strategic expansion of personnel, especially in diagnostics, combined with digital health solutions and role delegation, could yield substantial reductions in globa…
[News] Senators demand explanation for US Preventive Services Task Force halt
Nineteen US senators have written to Health and Human Services Secretary Robert F. Kennedy Jr. demanding an explanation for the year-long inactivity of the US Preventive Services Task Force (USPSTF), the independent panel that for four decades has determined which cancer screenings and preventive services Americans receive at no cost. The senators also called on Kennedy to submit a legally require…
Higher Cancer Mortality Rates Have Shifted From Urban to Rural Areas in US
A study published in JAMA reveals that the highest cancer mortality rates in the United States have shifted from urban to rural areas over the past five decades. This demographic reversal highlights growing healthcare disparities between metropolitan and non-metropolitan regions, likely driven by differences in access to screening, treatment facilities, and preventive care. The findings underscore…
Emerging trends in the global burden of colorectal cancer
A comprehensive review published in Nature Reviews Clinical Oncology examines the shifting global epidemiology of colorectal cancer, which has historically been concentrated in Western, high-income countries but is now rising worldwide. The authors identify early-onset colorectal cancer, diagnosed before age 50, as the primary driver of this increase. Proposed risk factors include dietary and life…
Uncovering risk factors in the exposome for early-onset colorectal cancer
A new perspective published in Nature Medicine examines the alarming rise in early-onset colorectal cancer and the role of environmental exposures — collectively known as the exposome — in driving this trend. The authors highlight epigenetic signatures as a promising tool to identify which environmental factors are contributing to the increasing incidence of colorectal cancer among younger individ…
CALYPSO: Final Results of Savolitinib and Durvalumab Combination in Metastatic Papillary Renal Cancer
The Journal of Clinical Oncology has published the final results of the CALYPSO trial evaluating the combination of savolitinib, a MET inhibitor, with durvalumab, an anti-PD-L1 immune checkpoint inhibitor, in patients with metastatic papillary renal cell carcinoma. Papillary RCC is a rare and historically difficult-to-treat subtype of kidney cancer with limited approved targeted options, making no…
[News] US EPA proposes easing ethylene oxide emission standards
The US Environmental Protection Agency has proposed regulatory changes that would roll back safeguards against air emissions of ethylene oxide (EtO), a substance classified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Announced on March 17, 2026, the proposed rule would relax continuous emissions monitoring requirements at approximately 90 commercial sterilisat…
[News] Rare Cancers Bill to become law in UK
On February 27, 2026, the UK Parliament voted to enact the Rare Cancers Bill into law, a landmark piece of legislation aimed at accelerating research and improving treatments and survival outcomes for patients with rare cancers, including brain tumours and pancreatic cancer. The bill was introduced by Scott Arthur, a Labour Party Member of Parliament from Scotland and a practising medical doctor. …
[Comment] NICE 2026 guideline for the diagnosis and management of kidney cancer
The Lancet Oncology has published a commentary on the new 2026 NICE guideline for the diagnosis and management of kidney cancer, the sixth most common cancer in UK adults with approximately 13,900 new cases diagnosed annually. The piece highlights that kidney cancer incidence has nearly doubled since the 1990s and is projected to continue rising through 2040, while UK five-year relative survival r…
Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma
A study published in Cancer Cell by Abdelfattah and colleagues has identified a sex-biased mechanism of immune evasion in Sonic Hedgehog (SHH) medulloblastoma, revealing that male tumors preferentially rely on the YAP1 transcription co-activator to upregulate the immune checkpoint molecule CD276 (B7-H3). The research demonstrates that immune checkpoint molecules in medulloblastoma cancer cells are…